Placental transfer of methylprednisolone following maternal intravenous administration
Seven normal patients in labor at term were given 125 mg of methylprednisolone hemisuccinate intravenously shortly before delivery. Analysis of maternal and cord plasma samples indicated that both the hemisuccinate and free alcohol forms of the corticosteroid were transported in pharmacologic levels...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1981-07, Vol.140 (6), p.699-701 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 140 |
| creator | Anderson, Gerald G. Rotchell, Yvonne Kaiser, David G. |
| description | Seven normal patients in labor at term were given 125 mg of methylprednisolone hemisuccinate intravenously shortly before delivery. Analysis of maternal and cord plasma samples indicated that both the hemisuccinate and free alcohol forms of the corticosteroid were transported in pharmacologic levels to the fetal compartment. Since methylprednisolone may have less of an infection-potentiating effect than other commonly used corticosteroids, use of it as a stimulator of fetal lung surfactant deserves further investigation. |
| doi_str_mv | 10.1016/0002-9378(81)90207-6 |
| format | Article |
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Analysis of maternal and cord plasma samples indicated that both the hemisuccinate and free alcohol forms of the corticosteroid were transported in pharmacologic levels to the fetal compartment. Since methylprednisolone may have less of an infection-potentiating effect than other commonly used corticosteroids, use of it as a stimulator of fetal lung surfactant deserves further investigation.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(81)90207-6</identifier><identifier>PMID: 7020419</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Female ; Humans ; Injections, Intravenous ; Maternal-Fetal Exchange ; Methylprednisolone - administration & dosage ; Methylprednisolone - analogs & derivatives ; Methylprednisolone - metabolism ; Methylprednisolone Hemisuccinate - administration & dosage ; Methylprednisolone Hemisuccinate - metabolism ; Pregnancy ; Radioimmunoassay</subject><ispartof>American journal of obstetrics and gynecology, 1981-07, Vol.140 (6), p.699-701</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-d956c3bc046b40d06282d7bb1c5d858778dcb750701c6a8f19b4b8ca9602850b3</citedby><cites>FETCH-LOGICAL-c423t-d956c3bc046b40d06282d7bb1c5d858778dcb750701c6a8f19b4b8ca9602850b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9378(81)90207-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7020419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anderson, Gerald G.</creatorcontrib><creatorcontrib>Rotchell, Yvonne</creatorcontrib><creatorcontrib>Kaiser, David G.</creatorcontrib><title>Placental transfer of methylprednisolone following maternal intravenous administration</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Seven normal patients in labor at term were given 125 mg of methylprednisolone hemisuccinate intravenously shortly before delivery. Analysis of maternal and cord plasma samples indicated that both the hemisuccinate and free alcohol forms of the corticosteroid were transported in pharmacologic levels to the fetal compartment. Since methylprednisolone may have less of an infection-potentiating effect than other commonly used corticosteroids, use of it as a stimulator of fetal lung surfactant deserves further investigation.</description><subject>Female</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Maternal-Fetal Exchange</subject><subject>Methylprednisolone - administration & dosage</subject><subject>Methylprednisolone - analogs & derivatives</subject><subject>Methylprednisolone - metabolism</subject><subject>Methylprednisolone Hemisuccinate - administration & dosage</subject><subject>Methylprednisolone Hemisuccinate - metabolism</subject><subject>Pregnancy</subject><subject>Radioimmunoassay</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPGzEURq2qVQih_6BIs6pgMWDPw49NJRQBRYpUFm23lh93ipHHTu1JUP49ThNl2ZUf93z32gehLwTfEEzoLca4qUXL-BUn1wI3mNX0A5oTLMqGU_4RzU_IGTrP-XV_bEQzQzNW8I6IOfr97JWBMClfTUmFPECq4lCNML3s_DqBDS5HHwNUQ_Q-vrnwpxrVBCmUhAsls4UQN7lSdnSFLReTi-ECfRqUz_D5uC7Qr4f7n8vv9erH49PyblWbrmmn2oqemlYb3FHdYYtpwxvLtCamt7znjHFrNOsxw8RQxQcidKe5UYLihvdYtwv09dB3neLfDeRJji4b8F4FKK-SrO25IB0rYHcATYo5JxjkOrlRpZ0kWO51yr0cuXclOZH_dEpaYpfH_hs9gj2Fjv5K_duhDuWTWwdJZuMgGLAugZmkje7_A94B8duFzA</recordid><startdate>19810715</startdate><enddate>19810715</enddate><creator>Anderson, Gerald G.</creator><creator>Rotchell, Yvonne</creator><creator>Kaiser, David G.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19810715</creationdate><title>Placental transfer of methylprednisolone following maternal intravenous administration</title><author>Anderson, Gerald G. ; Rotchell, Yvonne ; Kaiser, David G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-d956c3bc046b40d06282d7bb1c5d858778dcb750701c6a8f19b4b8ca9602850b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Female</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Maternal-Fetal Exchange</topic><topic>Methylprednisolone - administration & dosage</topic><topic>Methylprednisolone - analogs & derivatives</topic><topic>Methylprednisolone - metabolism</topic><topic>Methylprednisolone Hemisuccinate - administration & dosage</topic><topic>Methylprednisolone Hemisuccinate - metabolism</topic><topic>Pregnancy</topic><topic>Radioimmunoassay</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anderson, Gerald G.</creatorcontrib><creatorcontrib>Rotchell, Yvonne</creatorcontrib><creatorcontrib>Kaiser, David G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anderson, Gerald G.</au><au>Rotchell, Yvonne</au><au>Kaiser, David G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Placental transfer of methylprednisolone following maternal intravenous administration</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1981-07-15</date><risdate>1981</risdate><volume>140</volume><issue>6</issue><spage>699</spage><epage>701</epage><pages>699-701</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>Seven normal patients in labor at term were given 125 mg of methylprednisolone hemisuccinate intravenously shortly before delivery. Analysis of maternal and cord plasma samples indicated that both the hemisuccinate and free alcohol forms of the corticosteroid were transported in pharmacologic levels to the fetal compartment. Since methylprednisolone may have less of an infection-potentiating effect than other commonly used corticosteroids, use of it as a stimulator of fetal lung surfactant deserves further investigation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7020419</pmid><doi>10.1016/0002-9378(81)90207-6</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 1981-07, Vol.140 (6), p.699-701 |
| issn | 0002-9378 1097-6868 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73589147 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Female Humans Injections, Intravenous Maternal-Fetal Exchange Methylprednisolone - administration & dosage Methylprednisolone - analogs & derivatives Methylprednisolone - metabolism Methylprednisolone Hemisuccinate - administration & dosage Methylprednisolone Hemisuccinate - metabolism Pregnancy Radioimmunoassay |
| title | Placental transfer of methylprednisolone following maternal intravenous administration |
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