High-sensitivity quantitation of cabergoline and pergolide using a triple-quadrupole mass spectrometer with enhanced mass-resolution capabilities
Quantitative analysis of pharmaceuticals with low systemic plasma levels requires the utmost in sensitivity and selectivity from the analytical method used. A recently introduced triple‐quadrupole mass spectrometer with unique enhanced mass‐resolution capability was evaluated in the analysis of two...
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| Veröffentlicht in: | Journal of mass spectrometry. 2003-07, Vol.38 (7), p.743-751 |
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| container_title | Journal of mass spectrometry. |
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| creator | Hughes, Nicola Winnik, Witold Dunyach, Jean-Jacques Amad, Ma'an Splendore, Maurizio Paul, Gary |
| description | Quantitative analysis of pharmaceuticals with low systemic plasma levels requires the utmost in sensitivity and selectivity from the analytical method used. A recently introduced triple‐quadrupole mass spectrometer with unique enhanced mass‐resolution capability was evaluated in the analysis of two such drugs, cabergoline and pergolide, in plasma. Liquid chromatographic/electrospray ionization selected reaction monitoring determination of cabergoline in plasma at unit mass‐resolution demonstrated improved sensitivity (50 fg on‐column), coupled with suitable accuracy and precision over a broad linear dynamic range covering five orders of magnitude (50 fg to 5 ng on‐column). Liquid chromatographic/atmospheric pressure chemical ionization selective reaction monitoring determination of pergolide in plasma also attained a high level of sensitivity (500 fg on‐column) at unit mass‐resolution, with accuracy and precision values well within pharmaceutical industry standards. Again, a linear dynamic range covering five orders of magnitude (500 fg to 50 ng on‐column) was achieved for the assay. Utility of the enhanced mass‐resolution feature of the triple‐quadrupole mass spectrometer in the determination of pergolide resulted in an improvement in analyte sensitivity (250 fg on‐column) and linear dynamic range (250 fg to 50 ng on‐column). Copyright © 2003 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/jms.489 |
| format | Article |
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A recently introduced triple‐quadrupole mass spectrometer with unique enhanced mass‐resolution capability was evaluated in the analysis of two such drugs, cabergoline and pergolide, in plasma. Liquid chromatographic/electrospray ionization selected reaction monitoring determination of cabergoline in plasma at unit mass‐resolution demonstrated improved sensitivity (50 fg on‐column), coupled with suitable accuracy and precision over a broad linear dynamic range covering five orders of magnitude (50 fg to 5 ng on‐column). Liquid chromatographic/atmospheric pressure chemical ionization selective reaction monitoring determination of pergolide in plasma also attained a high level of sensitivity (500 fg on‐column) at unit mass‐resolution, with accuracy and precision values well within pharmaceutical industry standards. Again, a linear dynamic range covering five orders of magnitude (500 fg to 50 ng on‐column) was achieved for the assay. Utility of the enhanced mass‐resolution feature of the triple‐quadrupole mass spectrometer in the determination of pergolide resulted in an improvement in analyte sensitivity (250 fg on‐column) and linear dynamic range (250 fg to 50 ng on‐column). Copyright © 2003 John Wiley & Sons, Ltd.</description><identifier>ISSN: 1076-5174</identifier><identifier>EISSN: 1096-9888</identifier><identifier>DOI: 10.1002/jms.489</identifier><identifier>PMID: 12898654</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Analysis ; Animals ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; atmospheric pressure chemical ionization ; Biological and medical sciences ; Cattle ; Chromatography, High Pressure Liquid - methods ; Dopamine Agonists - blood ; electrospray ; enhanced mass-resolution ; Ergolines - blood ; General pharmacology ; linear dynamic range ; Medical sciences ; Neuropharmacology ; Pergolide - blood ; Pharmacology. Drug treatments ; quantitative analysis ; Reproducibility of Results ; Sensitivity and Specificity ; Spectrometry, Mass, Electrospray Ionization - instrumentation ; Spectrometry, Mass, Electrospray Ionization - methods</subject><ispartof>Journal of mass spectrometry., 2003-07, Vol.38 (7), p.743-751</ispartof><rights>Copyright © 2003 John Wiley & Sons, Ltd.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3469-c21feeba42d229fa15eab45e7bfa44997558e54a1a7c3b87bcfe6f09e73393663</citedby><cites>FETCH-LOGICAL-c3469-c21feeba42d229fa15eab45e7bfa44997558e54a1a7c3b87bcfe6f09e73393663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjms.489$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjms.489$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14944052$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12898654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hughes, Nicola</creatorcontrib><creatorcontrib>Winnik, Witold</creatorcontrib><creatorcontrib>Dunyach, Jean-Jacques</creatorcontrib><creatorcontrib>Amad, Ma'an</creatorcontrib><creatorcontrib>Splendore, Maurizio</creatorcontrib><creatorcontrib>Paul, Gary</creatorcontrib><title>High-sensitivity quantitation of cabergoline and pergolide using a triple-quadrupole mass spectrometer with enhanced mass-resolution capabilities</title><title>Journal of mass spectrometry.</title><addtitle>J. Mass Spectrom</addtitle><description>Quantitative analysis of pharmaceuticals with low systemic plasma levels requires the utmost in sensitivity and selectivity from the analytical method used. A recently introduced triple‐quadrupole mass spectrometer with unique enhanced mass‐resolution capability was evaluated in the analysis of two such drugs, cabergoline and pergolide, in plasma. Liquid chromatographic/electrospray ionization selected reaction monitoring determination of cabergoline in plasma at unit mass‐resolution demonstrated improved sensitivity (50 fg on‐column), coupled with suitable accuracy and precision over a broad linear dynamic range covering five orders of magnitude (50 fg to 5 ng on‐column). Liquid chromatographic/atmospheric pressure chemical ionization selective reaction monitoring determination of pergolide in plasma also attained a high level of sensitivity (500 fg on‐column) at unit mass‐resolution, with accuracy and precision values well within pharmaceutical industry standards. Again, a linear dynamic range covering five orders of magnitude (500 fg to 50 ng on‐column) was achieved for the assay. Utility of the enhanced mass‐resolution feature of the triple‐quadrupole mass spectrometer in the determination of pergolide resulted in an improvement in analyte sensitivity (250 fg on‐column) and linear dynamic range (250 fg to 50 ng on‐column). Copyright © 2003 John Wiley & Sons, Ltd.</description><subject>Analysis</subject><subject>Animals</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>atmospheric pressure chemical ionization</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Dopamine Agonists - blood</subject><subject>electrospray</subject><subject>enhanced mass-resolution</subject><subject>Ergolines - blood</subject><subject>General pharmacology</subject><subject>linear dynamic range</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pergolide - blood</subject><subject>Pharmacology. Drug treatments</subject><subject>quantitative analysis</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Spectrometry, Mass, Electrospray Ionization - instrumentation</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><issn>1076-5174</issn><issn>1096-9888</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10Mtu1DAUBuAIgWgpiDdA3kAXKMVJfF2iEZ2CCiwoqsTGOnFOZlycS22HMo_BG5NpRnTFyrb8-fzWn2UvC3pWUFq-u-niGVP6UXZcUC1yrZR6vN9LkfNCsqPsWYw3lFKtmXiaHRWl0kpwdpz9uXCbbR6xjy65Xy7tyO0EfXIJkht6MrTEQo1hM3jXI4G-IeNyapBM0fUbAiQFN3rM54dNmMbBI-kgRhJHtCkMHSYM5M6lLcF-C73F5v4-DxgHP93HWBihdn7-Asbn2ZMWfMQXh_Uk-37-4Wp1kV9-XX9cvb_MbcWEzm1ZtIg1sLIpS91CwRFqxlHWLTCmteRcIWdQgLRVrWRtWxQt1SirSldCVCfZm2XuGIbbCWMynYsWvYcehykaWXGlqSpneLpAG4YYA7ZmDK6DsDMFNfv2zdy-mduf5avDyKnusHlwh7pn8PoAIFrwbZjrcPHBMc0Y5fvIt4u7cx53_8sznz5_W2LzRbuY8Pc_DeGnEbKS3Fx_WZsr8aNarak019VfTHeu8Q</recordid><startdate>200307</startdate><enddate>200307</enddate><creator>Hughes, Nicola</creator><creator>Winnik, Witold</creator><creator>Dunyach, Jean-Jacques</creator><creator>Amad, Ma'an</creator><creator>Splendore, Maurizio</creator><creator>Paul, Gary</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200307</creationdate><title>High-sensitivity quantitation of cabergoline and pergolide using a triple-quadrupole mass spectrometer with enhanced mass-resolution capabilities</title><author>Hughes, Nicola ; Winnik, Witold ; Dunyach, Jean-Jacques ; Amad, Ma'an ; Splendore, Maurizio ; Paul, Gary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3469-c21feeba42d229fa15eab45e7bfa44997558e54a1a7c3b87bcfe6f09e73393663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>atmospheric pressure chemical ionization</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Dopamine Agonists - blood</topic><topic>electrospray</topic><topic>enhanced mass-resolution</topic><topic>Ergolines - blood</topic><topic>General pharmacology</topic><topic>linear dynamic range</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pergolide - blood</topic><topic>Pharmacology. Drug treatments</topic><topic>quantitative analysis</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Spectrometry, Mass, Electrospray Ionization - instrumentation</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hughes, Nicola</creatorcontrib><creatorcontrib>Winnik, Witold</creatorcontrib><creatorcontrib>Dunyach, Jean-Jacques</creatorcontrib><creatorcontrib>Amad, Ma'an</creatorcontrib><creatorcontrib>Splendore, Maurizio</creatorcontrib><creatorcontrib>Paul, Gary</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of mass spectrometry.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hughes, Nicola</au><au>Winnik, Witold</au><au>Dunyach, Jean-Jacques</au><au>Amad, Ma'an</au><au>Splendore, Maurizio</au><au>Paul, Gary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-sensitivity quantitation of cabergoline and pergolide using a triple-quadrupole mass spectrometer with enhanced mass-resolution capabilities</atitle><jtitle>Journal of mass spectrometry.</jtitle><addtitle>J. Mass Spectrom</addtitle><date>2003-07</date><risdate>2003</risdate><volume>38</volume><issue>7</issue><spage>743</spage><epage>751</epage><pages>743-751</pages><issn>1076-5174</issn><eissn>1096-9888</eissn><abstract>Quantitative analysis of pharmaceuticals with low systemic plasma levels requires the utmost in sensitivity and selectivity from the analytical method used. A recently introduced triple‐quadrupole mass spectrometer with unique enhanced mass‐resolution capability was evaluated in the analysis of two such drugs, cabergoline and pergolide, in plasma. Liquid chromatographic/electrospray ionization selected reaction monitoring determination of cabergoline in plasma at unit mass‐resolution demonstrated improved sensitivity (50 fg on‐column), coupled with suitable accuracy and precision over a broad linear dynamic range covering five orders of magnitude (50 fg to 5 ng on‐column). Liquid chromatographic/atmospheric pressure chemical ionization selective reaction monitoring determination of pergolide in plasma also attained a high level of sensitivity (500 fg on‐column) at unit mass‐resolution, with accuracy and precision values well within pharmaceutical industry standards. Again, a linear dynamic range covering five orders of magnitude (500 fg to 50 ng on‐column) was achieved for the assay. Utility of the enhanced mass‐resolution feature of the triple‐quadrupole mass spectrometer in the determination of pergolide resulted in an improvement in analyte sensitivity (250 fg on‐column) and linear dynamic range (250 fg to 50 ng on‐column). Copyright © 2003 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>12898654</pmid><doi>10.1002/jms.489</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of mass spectrometry., 2003-07, Vol.38 (7), p.743-751 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Analysis Animals Anticonvulsants. Antiepileptics. Antiparkinson agents atmospheric pressure chemical ionization Biological and medical sciences Cattle Chromatography, High Pressure Liquid - methods Dopamine Agonists - blood electrospray enhanced mass-resolution Ergolines - blood General pharmacology linear dynamic range Medical sciences Neuropharmacology Pergolide - blood Pharmacology. Drug treatments quantitative analysis Reproducibility of Results Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization - instrumentation Spectrometry, Mass, Electrospray Ionization - methods |
| title | High-sensitivity quantitation of cabergoline and pergolide using a triple-quadrupole mass spectrometer with enhanced mass-resolution capabilities |
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