Nuclear mRNA export: insights from virology
To maximize the production of progeny virions, several viruses have evolved mechanisms that promote the selective nuclear export of viral mRNA transcripts while, in some cases, inhibiting the export of cellular mRNAs. To achieve this goal, viruses have evolved regulatory proteins and cis-acting RNA...
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| Veröffentlicht in: | Trends in biochemical sciences (Amsterdam. Regular ed.) 2003-08, Vol.28 (8), p.419-424 |
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| container_title | Trends in biochemical sciences (Amsterdam. Regular ed.) |
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| creator | Cullen, Bryan R |
| description | To maximize the production of progeny virions, several viruses have evolved mechanisms that promote the selective nuclear export of viral mRNA transcripts while, in some cases, inhibiting the export of cellular mRNAs. To achieve this goal, viruses have evolved regulatory proteins and
cis-acting RNA elements that selectively interact with key cellular nuclear export factors. Efforts to identify the cellular targets of these viral proteins and RNA elements have led to the identification of Crm1 and Tap as essential human nuclear RNA-export factors and continue to provide insights into how mRNAs are selected for export |
| doi_str_mv | 10.1016/S0968-0004(03)00142-7 |
| format | Article |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Active Transport, Cell Nucleus Animals Cell Nucleus - metabolism Gene Products, rev - metabolism HIV-1 - physiology Models, Biological rev Gene Products, Human Immunodeficiency Virus RNA, Messenger - metabolism RNA, Viral |
| title | Nuclear mRNA export: insights from virology |
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