Diabetes Mellitus Adversely Affects the Outcomes of Thrombolytic Therapy in Patients with Acute Myocardial Infarction
This study was performed to evaluate whether coexistent diabetes mellitus has any adverse effect on the outcomes of thrombolytic therapy in patients with acute myocardial infarction. Although the early reperfusion rates were similar between the two groups of patients who had acute myocardial infarct...
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| Veröffentlicht in: | Angiology 2003-07, Vol.54 (4), p.449-456 |
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| creator | Tikiz, Hakan Tezcan, Ugur Ileri, Mehmet Balbay, Yücel Atak, Ramazan Kütük, Emine |
| description | This study was performed to evaluate whether coexistent diabetes mellitus has any adverse effect on the outcomes of thrombolytic therapy in patients with acute myocardial infarction. Although the early reperfusion rates were similar between the two groups of patients who had acute myocardial infarction with and without diabetes mellitus (42% vs 45.4%, p > 0.05), the results of late angiographic examination showed a significantly lower rate of patency in infarct- related coronary artery (defined as TIMI 3 flow) in diabetics compared to nondiabetics (28.9% vs 41.3%, p< 0.001). The global left ventricular function was also poorer in diabetics (left ventricular wall motion score was 18.6 ±7.3 in diabetics and 14.1 ±4.6 in nondiabetics, p < 0.01 1). |
| doi_str_mv | 10.1177/000331970305400409 |
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Although the early reperfusion rates were similar between the two groups of patients who had acute myocardial infarction with and without diabetes mellitus (42% vs 45.4%, p > 0.05), the results of late angiographic examination showed a significantly lower rate of patency in infarct- related coronary artery (defined as TIMI 3 flow) in diabetics compared to nondiabetics (28.9% vs 41.3%, p< 0.001). The global left ventricular function was also poorer in diabetics (left ventricular wall motion score was 18.6 ±7.3 in diabetics and 14.1 ±4.6 in nondiabetics, p < 0.01 1).</description><identifier>ISSN: 0003-3197</identifier><identifier>EISSN: 1940-1574</identifier><identifier>DOI: 10.1177/000331970305400409</identifier><identifier>PMID: 12934765</identifier><identifier>CODEN: ANGIAB</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Biological and medical sciences ; Blood. Blood coagulation. 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Jul/Aug 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c452t-1532e677e5cde3bf036f0b501577575fd55633536eba01ba166b70734a1435643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/000331970305400409$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/000331970305400409$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,777,781,21800,27905,27906,43602,43603</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15049453$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12934765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tikiz, Hakan</creatorcontrib><creatorcontrib>Tezcan, Ugur</creatorcontrib><creatorcontrib>Ileri, Mehmet</creatorcontrib><creatorcontrib>Balbay, Yücel</creatorcontrib><creatorcontrib>Atak, Ramazan</creatorcontrib><creatorcontrib>Kütük, Emine</creatorcontrib><title>Diabetes Mellitus Adversely Affects the Outcomes of Thrombolytic Therapy in Patients with Acute Myocardial Infarction</title><title>Angiology</title><addtitle>Angiology</addtitle><description>This study was performed to evaluate whether coexistent diabetes mellitus has any adverse effect on the outcomes of thrombolytic therapy in patients with acute myocardial infarction. Although the early reperfusion rates were similar between the two groups of patients who had acute myocardial infarction with and without diabetes mellitus (42% vs 45.4%, p > 0.05), the results of late angiographic examination showed a significantly lower rate of patency in infarct- related coronary artery (defined as TIMI 3 flow) in diabetics compared to nondiabetics (28.9% vs 41.3%, p< 0.001). The global left ventricular function was also poorer in diabetics (left ventricular wall motion score was 18.6 ±7.3 in diabetics and 14.1 ±4.6 in nondiabetics, p < 0.01 1).</description><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Cardiomyopathies - complications</subject><subject>Cardiomyopathies - drug therapy</subject><subject>Cardiomyopathies - physiopathology</subject><subject>Care and treatment</subject><subject>Collateral Circulation - physiology</subject><subject>Complications and side effects</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Diabetes</subject><subject>Diabetes Complications</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Fibrinolytic Agents - therapeutic use</subject><subject>Heart attack</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Streptokinase - therapeutic use</subject><subject>Thrombolytic Therapy</subject><subject>Tissue Plasminogen Activator - therapeutic use</subject><subject>Ventricular Function, Left - physiology</subject><issn>0003-3197</issn><issn>1940-1574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kk9v1DAQxS0EosvCF-CALFC5pbXjf-QYlQKVWpVDOUeOM951lcSL7RTl2-NoV1oBK-SDNdbvzfg9DUJvKbmgVKlLQghjtFKEEcEJ4aR6hla04qSgQvHnaLUAxUKcoVcxPuZSUCJfojNaVowrKVZo-ux0CwkivoO-d2mKuO6eIEToZ1xbCyZFnLaA76dk_JA5b_HDNvih9f2cnMkFBL2bsRvxd50cjFnwy6Utrs2UAN_N3ujQOd3jm9HqYJLz42v0wuo-wpvDvUY_vlw_XH0rbu-_3lzVt4XhokzZBitBKgXCdMBaS5i0pBUk21NCCdsJIRkTTEKrCW01lbJVRDGuKWdCcrZGH_d9d8H_nCCmZnDRZKN6BD_FRjHxSdHcY43e_wU--imM-W9NWXIpq1KKDH3YQxvdQ-NG61PQZunY1JSoklCec12j4gS1gTHH1PsRrMvPf_AXJ_h8OhicOSko9wITfIwBbLMLbtBhbihplsVo_l2MLHp3MDi1A3RHyWETMnB-AHQ0urdBj8bFIycIr7hYkrrcc1Fv4JjSf0b_BmPGygk</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>Tikiz, Hakan</creator><creator>Tezcan, Ugur</creator><creator>Ileri, Mehmet</creator><creator>Balbay, Yücel</creator><creator>Atak, Ramazan</creator><creator>Kütük, Emine</creator><general>SAGE Publications</general><general>Westminster</general><general>Sage Publications, Inc</general><general>SAGE PUBLICATIONS, INC</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20030701</creationdate><title>Diabetes Mellitus Adversely Affects the Outcomes of Thrombolytic Therapy in Patients with Acute Myocardial Infarction</title><author>Tikiz, Hakan ; Tezcan, Ugur ; Ileri, Mehmet ; Balbay, Yücel ; Atak, Ramazan ; Kütük, Emine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-1532e677e5cde3bf036f0b501577575fd55633536eba01ba166b70734a1435643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Cardiomyopathies - complications</topic><topic>Cardiomyopathies - drug therapy</topic><topic>Cardiomyopathies - physiopathology</topic><topic>Care and treatment</topic><topic>Collateral Circulation - physiology</topic><topic>Complications and side effects</topic><topic>Coronary Angiography</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Diabetes</topic><topic>Diabetes Complications</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Fibrinolytic Agents - therapeutic use</topic><topic>Heart attack</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. 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| ispartof | Angiology, 2003-07, Vol.54 (4), p.449-456 |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Cardiomyopathies - complications Cardiomyopathies - drug therapy Cardiomyopathies - physiopathology Care and treatment Collateral Circulation - physiology Complications and side effects Coronary Angiography Coronary Disease - diagnostic imaging Diabetes Diabetes Complications Diabetes Mellitus - physiopathology Electrocardiography Female Fibrinolytic Agents - therapeutic use Heart attack Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Streptokinase - therapeutic use Thrombolytic Therapy Tissue Plasminogen Activator - therapeutic use Ventricular Function, Left - physiology |
| title | Diabetes Mellitus Adversely Affects the Outcomes of Thrombolytic Therapy in Patients with Acute Myocardial Infarction |
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