Voltage-independent KCNQ4 currents induced by (+/-)BMS-204352

The compound BMS-204352 has been targeted for use against acute ischemic stroke, due to its activation of the large-conductance Ca2+-activated K-channel (BK). We have previously described that the racemate (+/-)BMS-204352 reversibly modulates KCNQ4 voltage dependency. Here we show that (+/-)BMS-2043...

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Veröffentlicht in:	Pflügers Archiv 2003-08, Vol.446 (5), p.607-616
Hauptverfasser:	Schrøder, Rikke Louise, Strøbaek, Dorte, Olesen, Søren-Peter, Christophersen, Palle
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Channel Agonists - pharmacology Cells CHO Cells Cricetinae Humans Indoles - pharmacology Ion Channel Gating - drug effects Ion Channel Gating - physiology KCNQ Potassium Channels Kidney - cytology Membrane Potentials - drug effects Membrane Potentials - physiology Patch-Clamp Techniques Potassium Channels - physiology Potassium Channels, Voltage-Gated
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