Host Factor Titration by Chromosomal R-loops as a Mechanism for Runaway Plasmid Replication in Transcription Termination-defective Mutants of Escherichia coli

Two Escherichia coli genes, rnhA and recG, encode products that disrupt R-loops by hydrolysis and unwinding, respectively. It is known that the propensity for R-loop formation in vivo is increased during growth at 21 °C. We have identified several links between rnhA, recG, and R-loop-dependent plasm...

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Veröffentlicht in:	Journal of molecular biology 2003-09, Vol.332 (1), p.31-46
Hauptverfasser:	Harinarayanan, R, Gowrishankar, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - genetics Bacterial Proteins - metabolism Chromosomes - genetics DNA Replication Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Mutation Nucleic Acid Conformation nusG Peptide Elongation Factors - genetics Peptide Elongation Factors - metabolism plasmid replication Plasmids - genetics Plasmids - metabolism R-loops rho Rho Factor - genetics Rho Factor - metabolism Ribonuclease H - genetics Ribonuclease H - metabolism Transcription Factors - genetics Transcription Factors - metabolism transcription termination Transcription, Genetic
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