Mouse Strain Susceptibility to Gonadectomy-Induced Adrenocortical Tumor Formation Correlates with the Expression of GATA-4 and Luteinizing Hormone Receptor

Certain inbred strains of mice, including DBA/2J, develop adrenocortical tumors in response to gonadectomy. Spindle-shaped cells with limited steroidogenic capacity, termed A cells, appear in the subcapsular region of the adrenal gland, followed by sex steroid-producing cells known as B cells. These...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2003-09, Vol.144 (9), p.4123-4133
Hauptverfasser:	Bielinska, Malgorzata, Parviainen, Helka, Porter-Tinge, Susan B, Kiiveri, Sanne, Genova, Elena, Rahman, Nafis, Huhtaniemi, Ilpo T, Muglia, Louis J, Heikinheimo, Markku, Wilson, David B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal cortex Adrenal Cortex - pathology Adrenal Cortex - physiopathology Adrenal Cortex Neoplasms - genetics Adrenal Cortex Neoplasms - pathology Adrenal Cortex Neoplasms - physiopathology Adrenal glands Animals Biological and medical sciences Biomarkers, Tumor Disease Susceptibility DNA-Binding Proteins - genetics Female Females Fetuses Fundamental and applied biological sciences. Psychology GATA4 Transcription Factor Gene expression Gene Expression Regulation, Neoplastic Gonadectomy Gonadotropins Hybridization Immunohistochemistry Inbreeding Inhibin Luteinizing hormone Lymphocytes B Male Mice Mice, Inbred C57BL Mice, Inbred DBA Oophorectomy Orchiectomy Ovariectomy Ovary - physiology Ovary - surgery Pituitary Pituitary (anterior) Receptors Receptors, LH - genetics Regeneration RNA, Messenger - analysis Sex Species Specificity Steroid 17-alpha-Hydroxylase - genetics Steroid hormones Steroids Transcription factors Transcription Factors - genetics Tumorigenesis Tumors Vertebrates: endocrinology
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