Analysis of CD10+ hairy cell leukemia
Hairy cell leukemia (HCL) has been reported to sometimes express CD10. However, the reported frequencies have been quite variable and the significance of CD10 expression has not been addressed. Cases of HCL submitted to our flow cytometry service during a 2-year period were evaluated for CD10 expres...
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| Veröffentlicht in: | American journal of clinical pathology 2003-08, Vol.120 (2), p.228-235 |
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| container_title | American journal of clinical pathology |
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| creator | JASIONOWSKI, Tammy M HARTUNG, Leah GREENWOOD, Jay H PERKINS, Sherrie L BAHLER, David W |
| description | Hairy cell leukemia (HCL) has been reported to sometimes express CD10. However, the reported frequencies have been quite variable and the significance of CD10 expression has not been addressed. Cases of HCL submitted to our flow cytometry service during a 2-year period were evaluated for CD10 expression. Information regarding demographics, clinical manifestations, tissue morphologic features, and response to treatment was reviewed. Of the 97 HCL cases identified, 10 expressed CD10. The level of CD10 staining was typically well above control levels and also could be detected easily by immunohistochemical analysis. All cases analyzed were negative for bcl-6. Our study suggests that approximately 10% of otherwise typical cases of HCL show aberrant CD10 expression. CD10+ HCL cases seem to be morphologically and clinically similar to CD10-HCL cases. Appreciating that HCL can express CD10 may be especially important when evaluating specimens with suboptimal morphologic features and/or limited immunophenotyping panels. |
| doi_str_mv | 10.1309/QVJD31TEG9UJ18BQ |
| format | Article |
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However, the reported frequencies have been quite variable and the significance of CD10 expression has not been addressed. Cases of HCL submitted to our flow cytometry service during a 2-year period were evaluated for CD10 expression. Information regarding demographics, clinical manifestations, tissue morphologic features, and response to treatment was reviewed. Of the 97 HCL cases identified, 10 expressed CD10. The level of CD10 staining was typically well above control levels and also could be detected easily by immunohistochemical analysis. All cases analyzed were negative for bcl-6. Our study suggests that approximately 10% of otherwise typical cases of HCL show aberrant CD10 expression. CD10+ HCL cases seem to be morphologically and clinically similar to CD10-HCL cases. 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However, the reported frequencies have been quite variable and the significance of CD10 expression has not been addressed. Cases of HCL submitted to our flow cytometry service during a 2-year period were evaluated for CD10 expression. Information regarding demographics, clinical manifestations, tissue morphologic features, and response to treatment was reviewed. Of the 97 HCL cases identified, 10 expressed CD10. The level of CD10 staining was typically well above control levels and also could be detected easily by immunohistochemical analysis. All cases analyzed were negative for bcl-6. Our study suggests that approximately 10% of otherwise typical cases of HCL show aberrant CD10 expression. CD10+ HCL cases seem to be morphologically and clinically similar to CD10-HCL cases. Appreciating that HCL can express CD10 may be especially important when evaluating specimens with suboptimal morphologic features and/or limited immunophenotyping panels.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Immunophenotyping</subject><subject>Leukemia, Hairy Cell - immunology</subject><subject>Leukemia, Hairy Cell - metabolism</subject><subject>Leukemia, Hairy Cell - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neprilysin - immunology</subject><subject>Neprilysin - metabolism</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFLwzAUxoMobk7vnqSXeZFqXl7SJMe5zekYyGDzWrI0wWq7zmY97L-3Y4OBF08PPn7fx-NHyC3QR0Cqn-Yf0xHCYjzRyymo5_kZ6YLmGEvJ2DnpUkpZrEFih1yF8EUpMEX5JekA0whCYJf0B2tT7EIeospHwxHQh-jT5PUusq4oosI1367MzTW58KYI7uZ4e2T5Ml4MX-PZ--RtOJjFlidqG5vEyxVHkSQZw8QrzKxEh1oqylAxMFJwrxU4dIxLqa1X0ln0lGfC6zbukfvD7qaufhoXtmmZh_0nZu2qJqQSheIg4F8QtABFBbYgPYC2rkKonU83dV6aepcCTfcO078O28rdcbtZlS47FY7SWqB_BEywpvC1Wds8nDhBOWCS4C-3y3az</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>JASIONOWSKI, Tammy M</creator><creator>HARTUNG, Leah</creator><creator>GREENWOOD, Jay H</creator><creator>PERKINS, Sherrie L</creator><creator>BAHLER, David W</creator><general>American Society of Clinical Pathologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>Analysis of CD10+ hairy cell leukemia</title><author>JASIONOWSKI, Tammy M ; HARTUNG, Leah ; GREENWOOD, Jay H ; PERKINS, Sherrie L ; BAHLER, David W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-a6f7b43566d236f83dc73e3978023821a754f981e3e24779cf87ec3f04d5f91e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Immunophenotyping</topic><topic>Leukemia, Hairy Cell - immunology</topic><topic>Leukemia, Hairy Cell - metabolism</topic><topic>Leukemia, Hairy Cell - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neprilysin - immunology</topic><topic>Neprilysin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JASIONOWSKI, Tammy M</creatorcontrib><creatorcontrib>HARTUNG, Leah</creatorcontrib><creatorcontrib>GREENWOOD, Jay H</creatorcontrib><creatorcontrib>PERKINS, Sherrie L</creatorcontrib><creatorcontrib>BAHLER, David W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JASIONOWSKI, Tammy M</au><au>HARTUNG, Leah</au><au>GREENWOOD, Jay H</au><au>PERKINS, Sherrie L</au><au>BAHLER, David W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of CD10+ hairy cell leukemia</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>120</volume><issue>2</issue><spage>228</spage><epage>235</epage><pages>228-235</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>Hairy cell leukemia (HCL) has been reported to sometimes express CD10. However, the reported frequencies have been quite variable and the significance of CD10 expression has not been addressed. Cases of HCL submitted to our flow cytometry service during a 2-year period were evaluated for CD10 expression. Information regarding demographics, clinical manifestations, tissue morphologic features, and response to treatment was reviewed. Of the 97 HCL cases identified, 10 expressed CD10. The level of CD10 staining was typically well above control levels and also could be detected easily by immunohistochemical analysis. All cases analyzed were negative for bcl-6. Our study suggests that approximately 10% of otherwise typical cases of HCL show aberrant CD10 expression. CD10+ HCL cases seem to be morphologically and clinically similar to CD10-HCL cases. Appreciating that HCL can express CD10 may be especially important when evaluating specimens with suboptimal morphologic features and/or limited immunophenotyping panels.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>12931553</pmid><doi>10.1309/QVJD31TEG9UJ18BQ</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press; EZB Electronic Journals Library |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - metabolism Female Flow Cytometry Hematologic and hematopoietic diseases Humans Immunoenzyme Techniques Immunophenotyping Leukemia, Hairy Cell - immunology Leukemia, Hairy Cell - metabolism Leukemia, Hairy Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Neprilysin - immunology Neprilysin - metabolism |
| title | Analysis of CD10+ hairy cell leukemia |
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