Disruption of Imprinted Gene Methylation and Expression in Cloned Preimplantation Stage Mouse Embryos

Cloning by somatic cell nuclear transfer requires that epigenetic information possessed by the donor nucleus be reprogrammed to an embryonic state. Little is known, however, about this remodeling process, including when it occurs, its efficiency, and how well epigenetic markings characteristic of no...

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Veröffentlicht in:	Biology of reproduction 2003-09, Vol.69 (3), p.902-914
Hauptverfasser:	MANN, Mellissa R. W, YOUNG GIE CHUNG, NOLEN, Leisha D, VERONA, Raluca I, LATHAM, Keith E, BARTOLOMEI, Marisa S
Format:	Artikel
Sprache:	eng
Schlagworte:	Allelic Imbalance - genetics Animals Biological and medical sciences Blastocyst - metabolism Cloning, Organism DNA Methylation Embryology: invertebrates and vertebrates. Teratology Epigenesis, Genetic - genetics Female Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Expression Regulation, Developmental - genetics Genomic Imprinting Male Mice Mice, Inbred C57BL Molecular embryology Nuclear Transfer Techniques
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