DNA looping and physical constraints on transcription regulation

DNA looping participates in transcriptional regulation, for instance, by allowing distal binding sites to act synergistically. Here, we study this process and compare different regulatory mechanisms based on repression with and without looping. Within a simple mathematical model for the lac operon,...

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Veröffentlicht in:	Journal of molecular biology 2003-08, Vol.331 (5), p.981-989
Hauptverfasser:	Vilar, José M G, Leibler, Stanislas
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites - genetics DNA - chemistry DNA - genetics Gene Expression Regulation Lac Operon Models, Genetic Nucleic Acid Conformation Repressor Proteins - genetics RNA, Messenger - genetics Thermodynamics Transcription, Genetic
Online-Zugang:	Volltext
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