Differential effects of leptin on cancer in vitro

Leptin, a protein produced by adipocytes, is an important signaling molecule in energy regulation and food intake. Many obese patients have leptin resistance associated with increased circulating leptin. Leptin receptor activation downregulates many regulatory genes, including STAT-3 and PAP 1. Cert...

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Veröffentlicht in:	The Journal of surgical research 2003-07, Vol.113 (1), p.50-55
Hauptverfasser:	Somasundar, Ponnandai, Yu, Alice K, Vona-Davis, Linda, McFadden, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences breast Breast Neoplasms - physiopathology Cell Division - drug effects Chemotherapy Esophageal Neoplasms - physiopathology Female Humans leptin Leptin - pharmacology Male Medical sciences Neoplastic Processes novel cancer therapy pancreas Pancreatic Neoplasms - physiopathology Pancreatitis-Associated Proteins Peptide Hormones - pharmacology Pharmacology. Drug treatments prostate and esophageal cancer Prostatic Neoplasms - physiopathology Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - physiology
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