An ultrastructural investigation into the size dependency of contractility of isolated cardiac muscle

An ultrastructural investigation into the size dependency of contractility of isolated cardiac muscle

The maximal stress (force per cross-sectional area), maximal rate of stress development, and cross-sectional area of 30 rabbit right ventricular papillary muscles were measured. Both mechanical parameters declined with increasing muscle size (the stress-area relation). Three large and three small mu...

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Veröffentlicht in:Cardiovascular research 1981-01, Vol.15 (1), p.21-27
Hauptverfasser: DELBRIDGE, LEANNE M, LOISELLE, DENIS S
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Sprache:eng
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Animals
Male
Microscopy, Electron
Mitochondria, Heart - physiology
Myocardial Contraction
Papillary Muscles - ultrastructure
Rabbits
Stress, Mechanical
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creator DELBRIDGE, LEANNE M
LOISELLE, DENIS S
description The maximal stress (force per cross-sectional area), maximal rate of stress development, and cross-sectional area of 30 rabbit right ventricular papillary muscles were measured. Both mechanical parameters declined with increasing muscle size (the stress-area relation). Three large and three small muscles were fixed for electronmicroscopy. Stereological analyses of these six muscles were undertaken to test the hypothesis that the stress-area relation is caused by differences in the relative proportions of mitochondria and contractile matrix between muscles of large and small cross-sectional area. No difference in the proportion of these two cytoplasmic components was found. Other possible explanations underlying the stress-area relation are discussed.
doi_str_mv 10.1093/cvr/15.1.21
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subjects Animals
Male
Microscopy, Electron
Mitochondria, Heart - physiology
Myocardial Contraction
Papillary Muscles - ultrastructure
Rabbits
Stress, Mechanical
title An ultrastructural investigation into the size dependency of contractility of isolated cardiac muscle
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