Molecular Phylogeny within Type I Cytokines and Their Cognate Receptors
Type I helical cytokines are ligands for receptors structurally related by a common sequence signature. Here we analyze the 27 ligands and 34 human type I cytokine receptor encoded by the human genome. We compare these to ligands and receptors found in mouse and insects. We describe their structural...
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| Veröffentlicht in: | Immunity 2003-08, Vol.19 (2), p.159-163 |
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| creator | Boulay, Jean-Louis O'Shea, John J. Paul, William E. |
| description | Type I helical cytokines are ligands for receptors structurally related by a common sequence signature. Here we analyze the 27 ligands and 34 human type I cytokine receptor encoded by the human genome. We compare these to ligands and receptors found in mouse and insects. We describe their structural relatedness to one another and discuss the evolution of these gene families. |
| doi_str_mv | 10.1016/S1074-7613(03)00211-5 |
| format | Article |
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| ispartof | Immunity, 2003-08, Vol.19 (2), p.159-163 |
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| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Anopheles - genetics Anopheles - immunology Automation Cytokines - classification Cytokines - genetics Cytokines - metabolism Drosophila - genetics Drosophila - immunology Evolution, Molecular Genes Genomes Growth hormones Humans Insects Ligands Mice Multigene Family Phylogeny Protein-Tyrosine Kinases - metabolism Receptors, Cytokine - genetics Receptors, Cytokine - metabolism Signal Transduction Species Specificity Transcription Factors - metabolism |
| title | Molecular Phylogeny within Type I Cytokines and Their Cognate Receptors |
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