Tremor of the mouth floor and anti-glutamic acid decarboxylase autoantibodies
Involuntary movements of the mouth can present as palatal tremor, which is frequently associated with hypertrophy of the inferior olivary nucleus and can be accompanied by contraction of other muscles of the head. We report the case of a 39‐year‐old man with autoimmune thyroiditis and diabetes who c...
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| Veröffentlicht in: | European journal of neurology 2003-09, Vol.10 (5), p.513-514 |
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| creator | Vianello, M. Morello, F. Scaravilli, T. Tavolato, B. Giometto, B. |
| description | Involuntary movements of the mouth can present as palatal tremor, which is frequently associated with hypertrophy of the inferior olivary nucleus and can be accompanied by contraction of other muscles of the head. We report the case of a 39‐year‐old man with autoimmune thyroiditis and diabetes who complained of involuntary rhythmic tremor involving the muscles of the floor of the mouth, which interfered with breathing and swallowing. Cerebrospinal fluid (CSF) examination showed the presence of oligoclonal bands and screening for anti‐neuronal antibodies revealed high titres of anti‐glutamic acid decarboxylase autoantibodies (GAD‐Ab). Tremor responded to treatment with benzodiazepines. The correlation between the tremor and antibody positivity is unclear although an alteration of the gabaergic system mediated by the antibodies may be hypothesised on the basis of an inflammatory CSF profile. |
| doi_str_mv | 10.1046/j.1468-1331.2003.00629.x |
| format | Article |
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We report the case of a 39‐year‐old man with autoimmune thyroiditis and diabetes who complained of involuntary rhythmic tremor involving the muscles of the floor of the mouth, which interfered with breathing and swallowing. Cerebrospinal fluid (CSF) examination showed the presence of oligoclonal bands and screening for anti‐neuronal antibodies revealed high titres of anti‐glutamic acid decarboxylase autoantibodies (GAD‐Ab). Tremor responded to treatment with benzodiazepines. 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We report the case of a 39‐year‐old man with autoimmune thyroiditis and diabetes who complained of involuntary rhythmic tremor involving the muscles of the floor of the mouth, which interfered with breathing and swallowing. Cerebrospinal fluid (CSF) examination showed the presence of oligoclonal bands and screening for anti‐neuronal antibodies revealed high titres of anti‐glutamic acid decarboxylase autoantibodies (GAD‐Ab). Tremor responded to treatment with benzodiazepines. The correlation between the tremor and antibody positivity is unclear although an alteration of the gabaergic system mediated by the antibodies may be hypothesised on the basis of an inflammatory CSF profile.</description><subject>Adult</subject><subject>anti-glutamic acid decarboxylase antibodies</subject><subject>Autoantibodies - cerebrospinal fluid</subject><subject>Diabetes Mellitus, Type 1 - cerebrospinal fluid</subject><subject>Diabetes Mellitus, Type 1 - enzymology</subject><subject>Glutamate Decarboxylase - cerebrospinal fluid</subject><subject>Humans</subject><subject>Male</subject><subject>Mouth Floor</subject><subject>palatal tremor</subject><subject>polyglandular autoimmune disorders</subject><subject>Thyroiditis, Autoimmune - cerebrospinal fluid</subject><subject>Thyroiditis, Autoimmune - enzymology</subject><subject>Tremor - diagnosis</subject><subject>Tremor - drug therapy</subject><subject>Tremor - enzymology</subject><issn>1351-5101</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1P3DAQhq2qFUspfwHlxC3p-CN2LPVS0S0FLQtCtJV6sexkAlkSDHYidv89CbuiVw6WRzPPOyM9hCQUMgpCfl1lVMgipZzTjAHwDEAyna0_kP23wcex5jlNcwp0Rj7HuAIAphjskRllWkDB6T65uAnY-ZD4OunvMOn80N8ldevHln2oxtc36W079LZrysSWTZVUWNrg_HrT2oiJHXo_Qc5XDcYv5FNt24iHu_-A_P45vzn5lS4uT89Ovi_SUgDTqeNUAhSVqhG4RUudLgSXGismSq6dzqVzvAKFVhZKcSFdboXOmUKnakb5ATne7n0M_mnA2JuuiSW2rX1AP0SjeK40FWwEiy1YBh9jwNo8hqazYWMomEmlWZnJmJmMmUmleVVp1mP0aHdjcB1W_4M7dyPwbQs8Ny1u3r3YzJfzsRjj6TbexB7Xb3Eb7o1UXOXm7_LUsH_LP-rq-tz84C-pMJDw</recordid><startdate>200309</startdate><enddate>200309</enddate><creator>Vianello, M.</creator><creator>Morello, F.</creator><creator>Scaravilli, T.</creator><creator>Tavolato, B.</creator><creator>Giometto, B.</creator><general>Blackwell Science Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200309</creationdate><title>Tremor of the mouth floor and anti-glutamic acid decarboxylase autoantibodies</title><author>Vianello, M. ; Morello, F. ; Scaravilli, T. ; Tavolato, B. ; Giometto, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4029-b316008d7fe03aea1b984369ed24c39b956bb3d07ea6877346b5a49527eb7f213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>anti-glutamic acid decarboxylase antibodies</topic><topic>Autoantibodies - cerebrospinal fluid</topic><topic>Diabetes Mellitus, Type 1 - cerebrospinal fluid</topic><topic>Diabetes Mellitus, Type 1 - enzymology</topic><topic>Glutamate Decarboxylase - cerebrospinal fluid</topic><topic>Humans</topic><topic>Male</topic><topic>Mouth Floor</topic><topic>palatal tremor</topic><topic>polyglandular autoimmune disorders</topic><topic>Thyroiditis, Autoimmune - cerebrospinal fluid</topic><topic>Thyroiditis, Autoimmune - enzymology</topic><topic>Tremor - diagnosis</topic><topic>Tremor - drug therapy</topic><topic>Tremor - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vianello, M.</creatorcontrib><creatorcontrib>Morello, F.</creatorcontrib><creatorcontrib>Scaravilli, T.</creatorcontrib><creatorcontrib>Tavolato, B.</creatorcontrib><creatorcontrib>Giometto, B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vianello, M.</au><au>Morello, F.</au><au>Scaravilli, T.</au><au>Tavolato, B.</au><au>Giometto, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tremor of the mouth floor and anti-glutamic acid decarboxylase autoantibodies</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2003-09</date><risdate>2003</risdate><volume>10</volume><issue>5</issue><spage>513</spage><epage>514</epage><pages>513-514</pages><issn>1351-5101</issn><eissn>1468-1331</eissn><abstract>Involuntary movements of the mouth can present as palatal tremor, which is frequently associated with hypertrophy of the inferior olivary nucleus and can be accompanied by contraction of other muscles of the head. We report the case of a 39‐year‐old man with autoimmune thyroiditis and diabetes who complained of involuntary rhythmic tremor involving the muscles of the floor of the mouth, which interfered with breathing and swallowing. Cerebrospinal fluid (CSF) examination showed the presence of oligoclonal bands and screening for anti‐neuronal antibodies revealed high titres of anti‐glutamic acid decarboxylase autoantibodies (GAD‐Ab). Tremor responded to treatment with benzodiazepines. The correlation between the tremor and antibody positivity is unclear although an alteration of the gabaergic system mediated by the antibodies may be hypothesised on the basis of an inflammatory CSF profile.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>12940831</pmid><doi>10.1046/j.1468-1331.2003.00629.x</doi><tpages>2</tpages></addata></record> |
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| subjects | Adult anti-glutamic acid decarboxylase antibodies Autoantibodies - cerebrospinal fluid Diabetes Mellitus, Type 1 - cerebrospinal fluid Diabetes Mellitus, Type 1 - enzymology Glutamate Decarboxylase - cerebrospinal fluid Humans Male Mouth Floor palatal tremor polyglandular autoimmune disorders Thyroiditis, Autoimmune - cerebrospinal fluid Thyroiditis, Autoimmune - enzymology Tremor - diagnosis Tremor - drug therapy Tremor - enzymology |
| title | Tremor of the mouth floor and anti-glutamic acid decarboxylase autoantibodies |
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