Evaluation of anti-inﬂammatory potential of Pavetta indica Linn. leaf extract (family: Rubiaceae) in rats

The anti‐inﬂammatory potential of methanol extract of Pavetta indica Linn. leaves (Family: Rubiaceae) was evaluated against several models of inﬂammation such as carragenin, histamine and dextran induced pedal inﬂammation in rats. The extract showed 48.41%, 41.10% and 24.22% inhibition respectively;...

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Veröffentlicht in:	Phytotherapy research 2003-08, Vol.17 (7), p.817-820
Hauptverfasser:	Mandal, Subhash C., Mohana Lakshmi, S., Ashok Kumar, C. K., Sur, Tapas K., Boominathan, R.
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Schlagworte:	Administration, Oral Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use anti-inﬂammatory Biological and medical sciences Carrageenan Dextrans Dose-Response Relationship, Drug Edema - chemically induced Edema - prevention & control General pharmacology Granuloma, Foreign-Body - prevention & control Histamine Indomethacin - pharmacology leaf extract Male Medical sciences MEPI Pavetta indica Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Leaves Rats Rats, Wistar Rubiaceae
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creator	Mandal, Subhash C. Mohana Lakshmi, S. Ashok Kumar, C. K. Sur, Tapas K. Boominathan, R.
description	The anti‐inﬂammatory potential of methanol extract of Pavetta indica Linn. leaves (Family: Rubiaceae) was evaluated against several models of inﬂammation such as carragenin, histamine and dextran induced pedal inﬂammation in rats. The extract showed 48.41%, 41.10% and 24.22% inhibition respectively; when compared to that of control animals. The effect was comparable with that of the standard drug indomethacin, a standard non‐steroidal anti‐inﬂammatory drug. Simultaneous subplantar administration of the extract and carrageenin in a mixture helps in differentiating true anti‐inﬂammatory action from an apparent anti‐inﬂammatory effect due to counter‐irritant activity. The methanol extract also effectively and signiﬁcantly reduced cotton pellet induced granuloma. The percentage of inhibition was 62.78 at the dose 500 mg/kg, thereby suggesting its activity in the proliferative phase of the inﬂammatory process. Copyright © 2003 John Wiley & Sons, Ltd.
doi_str_mv	10.1002/ptr.1095
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The percentage of inhibition was 62.78 at the dose 500 mg/kg, thereby suggesting its activity in the proliferative phase of the inﬂammatory process. 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K.</creatorcontrib><creatorcontrib>Sur, Tapas K.</creatorcontrib><creatorcontrib>Boominathan, R.</creatorcontrib><title>Evaluation of anti-inﬂammatory potential of Pavetta indica Linn. leaf extract (family: Rubiaceae) in rats</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The anti‐inﬂammatory potential of methanol extract of Pavetta indica Linn. leaves (Family: Rubiaceae) was evaluated against several models of inﬂammation such as carragenin, histamine and dextran induced pedal inﬂammation in rats. The extract showed 48.41%, 41.10% and 24.22% inhibition respectively; when compared to that of control animals. The effect was comparable with that of the standard drug indomethacin, a standard non‐steroidal anti‐inﬂammatory drug. Simultaneous subplantar administration of the extract and carrageenin in a mixture helps in differentiating true anti‐inﬂammatory action from an apparent anti‐inﬂammatory effect due to counter‐irritant activity. The methanol extract also effectively and signiﬁcantly reduced cotton pellet induced granuloma. The percentage of inhibition was 62.78 at the dose 500 mg/kg, thereby suggesting its activity in the proliferative phase of the inﬂammatory process. 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Health food</subject><subject>Pharmacology. 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Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Leaves</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rubiaceae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mandal, Subhash C.</creatorcontrib><creatorcontrib>Mohana Lakshmi, S.</creatorcontrib><creatorcontrib>Ashok Kumar, C. 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Res</addtitle><date>2003-08</date><risdate>2003</risdate><volume>17</volume><issue>7</issue><spage>817</spage><epage>820</epage><pages>817-820</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>The anti‐inﬂammatory potential of methanol extract of Pavetta indica Linn. leaves (Family: Rubiaceae) was evaluated against several models of inﬂammation such as carragenin, histamine and dextran induced pedal inﬂammation in rats. The extract showed 48.41%, 41.10% and 24.22% inhibition respectively; when compared to that of control animals. The effect was comparable with that of the standard drug indomethacin, a standard non‐steroidal anti‐inﬂammatory drug. Simultaneous subplantar administration of the extract and carrageenin in a mixture helps in differentiating true anti‐inﬂammatory action from an apparent anti‐inﬂammatory effect due to counter‐irritant activity. The methanol extract also effectively and signiﬁcantly reduced cotton pellet induced granuloma. 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subjects	Administration, Oral Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use anti-inﬂammatory Biological and medical sciences Carrageenan Dextrans Dose-Response Relationship, Drug Edema - chemically induced Edema - prevention & control General pharmacology Granuloma, Foreign-Body - prevention & control Histamine Indomethacin - pharmacology leaf extract Male Medical sciences MEPI Pavetta indica Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Leaves Rats Rats, Wistar Rubiaceae
title	Evaluation of anti-inﬂammatory potential of Pavetta indica Linn. leaf extract (family: Rubiaceae) in rats
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