Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes

Two mutants of Aspergillus terreus with either the lovC or lovA genes disrupted were examined for their ability to transform nonaketides into lovastatin 1, a cholesterol-lowering drug. The lovC disruptant was able to efficiently convert dihydromonacolin L 5 or monacolin J 9 into 1, and could also tr...

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Veröffentlicht in:	Organic & biomolecular chemistry 2003-01, Vol.1 (1), p.50-59
Hauptverfasser:	Sorensen, John L, Auclair, Karine, Kennedy, Jonathan, Hutchinson, C Richard, Vederas, John C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspergillus - genetics Crystallography, X-Ray Fermentation Fungal Proteins - genetics Lovastatin - biosynthesis Lovastatin - chemistry Models, Chemical Models, Genetic Multienzyme Complexes - genetics Mutation Naphthalenes - chemistry Oxygen - metabolism
Online-Zugang:	Volltext
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