Subacute Thyroiditis with Highly Positive Thyrotropin Receptor Antibodies and High Thyroidal Radioactive Iodine Uptake
A 48-year-old woman with transient thyrotoxicosis, having a slightly high thyroidal 99mTc uptake (3.9% at 20 m) or radioactive iodine uptake (RAIU) (17.3% at 4 hour) and subacute thyroiditis (SAT)-like symptoms, signs and histological diagnosis (extensive cellular destruction and granulomatous infla...
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| Veröffentlicht in: | Internal Medicine 2003, Vol.42(8), pp.704-709 |
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| creator | FUJII, Sumie MIWA, Umeo SETA, Takashi OHOKA, Takio MIZUKAMI, Yuji |
| description | A 48-year-old woman with transient thyrotoxicosis, having a slightly high thyroidal 99mTc uptake (3.9% at 20 m) or radioactive iodine uptake (RAIU) (17.3% at 4 hour) and subacute thyroiditis (SAT)-like symptoms, signs and histological diagnosis (extensive cellular destruction and granulomatous inflammatory change), showed positive TRAb (59.9%) and TSAb (194%) activity. The high levels of TRAb and slightly high RAIU were still observed after one month of prednisolone treatment. Nine months later, the TRAb and TSAb levels finally normalized and her thyroid function has remained normal since then. We suspect that the slightly high RAIU were due to the presence of both the TRAb and the TSAb and the course of this case might mimic neonatal Graves' disease. (Internal Medicine 42: 704-709, 2003) |
| doi_str_mv | 10.2169/internalmedicine.42.704 |
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The high levels of TRAb and slightly high RAIU were still observed after one month of prednisolone treatment. Nine months later, the TRAb and TSAb levels finally normalized and her thyroid function has remained normal since then. We suspect that the slightly high RAIU were due to the presence of both the TRAb and the TSAb and the course of this case might mimic neonatal Graves' disease. (Internal Medicine 42: 704-709, 2003)</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.42.704</identifier><identifier>PMID: 12924496</identifier><language>eng</language><publisher>Tokyo: The Japanese Society of Internal Medicine</publisher><subject>Autoantibodies - immunology ; Biological and medical sciences ; Endocrinopathies ; Female ; Graves Disease - complications ; Graves Disease - diagnostic imaging ; Graves Disease - immunology ; Graves' disease ; Humans ; Immunoglobulins, Thyroid-Stimulating - immunology ; Iodine Radioisotopes ; Medical sciences ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Radionuclide Imaging ; Receptors, Thyrotropin - immunology ; subacute thyroiditis (SAT) ; Thyroid Gland - diagnostic imaging ; thyroid stimulating antibody (TSAb) ; Thyroid. Thyroid axis (diseases) ; Thyroiditis, Subacute - complications ; Thyroiditis, Subacute - diagnostic imaging ; Thyroiditis, Subacute - immunology ; TSH receptor antibody (TRAb)</subject><ispartof>Internal Medicine, 2003, Vol.42(8), pp.704-709</ispartof><rights>The Japanese Society of Internal Medicine</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-b88ba6ffd91ab0a2d56a62f52f631bd431cc98983371260e8bca78c5c45d90ff3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1882,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15178060$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12924496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FUJII, Sumie</creatorcontrib><creatorcontrib>MIWA, Umeo</creatorcontrib><creatorcontrib>SETA, Takashi</creatorcontrib><creatorcontrib>OHOKA, Takio</creatorcontrib><creatorcontrib>MIZUKAMI, Yuji</creatorcontrib><title>Subacute Thyroiditis with Highly Positive Thyrotropin Receptor Antibodies and High Thyroidal Radioactive Iodine Uptake</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 48-year-old woman with transient thyrotoxicosis, having a slightly high thyroidal 99mTc uptake (3.9% at 20 m) or radioactive iodine uptake (RAIU) (17.3% at 4 hour) and subacute thyroiditis (SAT)-like symptoms, signs and histological diagnosis (extensive cellular destruction and granulomatous inflammatory change), showed positive TRAb (59.9%) and TSAb (194%) activity. The high levels of TRAb and slightly high RAIU were still observed after one month of prednisolone treatment. Nine months later, the TRAb and TSAb levels finally normalized and her thyroid function has remained normal since then. We suspect that the slightly high RAIU were due to the presence of both the TRAb and the TSAb and the course of this case might mimic neonatal Graves' disease. (Internal Medicine 42: 704-709, 2003)</description><subject>Autoantibodies - immunology</subject><subject>Biological and medical sciences</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Graves Disease - complications</subject><subject>Graves Disease - diagnostic imaging</subject><subject>Graves Disease - immunology</subject><subject>Graves' disease</subject><subject>Humans</subject><subject>Immunoglobulins, Thyroid-Stimulating - immunology</subject><subject>Iodine Radioisotopes</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Radionuclide Imaging</subject><subject>Receptors, Thyrotropin - immunology</subject><subject>subacute thyroiditis (SAT)</subject><subject>Thyroid Gland - diagnostic imaging</subject><subject>thyroid stimulating antibody (TSAb)</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Thyroiditis, Subacute - complications</subject><subject>Thyroiditis, Subacute - diagnostic imaging</subject><subject>Thyroiditis, Subacute - immunology</subject><subject>TSH receptor antibody (TRAb)</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkFtv1DAQha2Kql0KfwH8Am9ZfEkc-7GqgFaqRNXLszVx7K5L1gm2U7T_HrcbWgleZqSZ78wcHYQ-UrJmVKgvPmQbAwxb23vjg13XbN2S-gCtKK9V1TLevEEroqisWCnH6G1KD4Rw2Sp2hI4pU6yulVihx5u5AzNni283uzj63mef8G-fN_jc32-GHb4aU5k9LkCO4-QDvrbGTnmM-DRk3429twlD6J81fy_BgK-h9yOYZ_lFoYLFd1OGn_YdOnQwJPt-6Sfo7tvX27Pz6vLH94uz08vKNITlqpOyA-Fcryh0BFjfCBDMNcwJTru-5tQYJZXkvKVMECs7A600jambXhHn-An6vL87xfHXbFPWW5-MHQYIdpyTbnkjlBRtAds9aOKYUrROT9FvIe40Jfopcv1v5LpmukRelB-WF3NXdq-6JeMCfFoASAYGFyEYn165hraSCFK4qz33kDLc2xcAYvZmsP8ZoEqxJxNyX4qXF9RsIGob-B-uxK-R</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>FUJII, Sumie</creator><creator>MIWA, Umeo</creator><creator>SETA, Takashi</creator><creator>OHOKA, Takio</creator><creator>MIZUKAMI, Yuji</creator><general>The Japanese Society of Internal Medicine</general><general>Japanese Society of Internal Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>Subacute Thyroiditis with Highly Positive Thyrotropin Receptor Antibodies and High Thyroidal Radioactive Iodine Uptake</title><author>FUJII, Sumie ; MIWA, Umeo ; SETA, Takashi ; OHOKA, Takio ; MIZUKAMI, Yuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-b88ba6ffd91ab0a2d56a62f52f631bd431cc98983371260e8bca78c5c45d90ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Autoantibodies - immunology</topic><topic>Biological and medical sciences</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Graves Disease - complications</topic><topic>Graves Disease - diagnostic imaging</topic><topic>Graves Disease - immunology</topic><topic>Graves' disease</topic><topic>Humans</topic><topic>Immunoglobulins, Thyroid-Stimulating - immunology</topic><topic>Iodine Radioisotopes</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Radionuclide Imaging</topic><topic>Receptors, Thyrotropin - immunology</topic><topic>subacute thyroiditis (SAT)</topic><topic>Thyroid Gland - diagnostic imaging</topic><topic>thyroid stimulating antibody (TSAb)</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Thyroiditis, Subacute - complications</topic><topic>Thyroiditis, Subacute - diagnostic imaging</topic><topic>Thyroiditis, Subacute - immunology</topic><topic>TSH receptor antibody (TRAb)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FUJII, Sumie</creatorcontrib><creatorcontrib>MIWA, Umeo</creatorcontrib><creatorcontrib>SETA, Takashi</creatorcontrib><creatorcontrib>OHOKA, Takio</creatorcontrib><creatorcontrib>MIZUKAMI, Yuji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FUJII, Sumie</au><au>MIWA, Umeo</au><au>SETA, Takashi</au><au>OHOKA, Takio</au><au>MIZUKAMI, Yuji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subacute Thyroiditis with Highly Positive Thyrotropin Receptor Antibodies and High Thyroidal Radioactive Iodine Uptake</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>42</volume><issue>8</issue><spage>704</spage><epage>709</epage><pages>704-709</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>A 48-year-old woman with transient thyrotoxicosis, having a slightly high thyroidal 99mTc uptake (3.9% at 20 m) or radioactive iodine uptake (RAIU) (17.3% at 4 hour) and subacute thyroiditis (SAT)-like symptoms, signs and histological diagnosis (extensive cellular destruction and granulomatous inflammatory change), showed positive TRAb (59.9%) and TSAb (194%) activity. The high levels of TRAb and slightly high RAIU were still observed after one month of prednisolone treatment. Nine months later, the TRAb and TSAb levels finally normalized and her thyroid function has remained normal since then. We suspect that the slightly high RAIU were due to the presence of both the TRAb and the TSAb and the course of this case might mimic neonatal Graves' disease. (Internal Medicine 42: 704-709, 2003)</abstract><cop>Tokyo</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>12924496</pmid><doi>10.2169/internalmedicine.42.704</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Autoantibodies - immunology Biological and medical sciences Endocrinopathies Female Graves Disease - complications Graves Disease - diagnostic imaging Graves Disease - immunology Graves' disease Humans Immunoglobulins, Thyroid-Stimulating - immunology Iodine Radioisotopes Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Radionuclide Imaging Receptors, Thyrotropin - immunology subacute thyroiditis (SAT) Thyroid Gland - diagnostic imaging thyroid stimulating antibody (TSAb) Thyroid. Thyroid axis (diseases) Thyroiditis, Subacute - complications Thyroiditis, Subacute - diagnostic imaging Thyroiditis, Subacute - immunology TSH receptor antibody (TRAb) |
| title | Subacute Thyroiditis with Highly Positive Thyrotropin Receptor Antibodies and High Thyroidal Radioactive Iodine Uptake |
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