The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation
Proneural genes encode basic-helix-loop-helix (bHLH) transcription factors required for neural precursor specification. Recently amos was identified as a new candidate Drosophila proneural gene related to atonal . Having isolated the first specific amos loss-of-function mutations, we show definitive...
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| Veröffentlicht in: | Development (Cambridge) 2003-10, Vol.130 (19), p.4683-4693 |
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| creator | zur Lage, Petra I Prentice, David R A Holohan, Eimear E Jarman, Andrew P |
| description | Proneural genes encode basic-helix-loop-helix (bHLH) transcription factors required for neural precursor specification. Recently amos was identified as a new candidate Drosophila proneural gene related to atonal . Having isolated the first specific amos loss-of-function mutations, we show definitively that amos is required to specify the precursors of two classes of olfactory sensilla. Unlike other known proneural mutations, a novel characteristic of amos loss of function is the appearance of ectopic sensory bristles in addition to loss of olfactory sensilla, owing to the inappropriate function of scute . This supports a model of inhibitory interactions between proneural genes, whereby ato -like genes ( amos and ato ) must suppress sensory bristle fate as well as promote alternative sense organ subtypes. |
| doi_str_mv | 10.1242/dev.00680 |
| format | Article |
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Prentice, David R A ; Holohan, Eimear E ; Jarman, Andrew P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-994e36c580ba59c44fb46d8f315205f0c9b98bcdbb1860d3c57e803d54de76893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Basic Helix-Loop-Helix Transcription Factors</topic><topic>Cell Lineage</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Drosophila melanogaster - anatomy & histology</topic><topic>Drosophila melanogaster - embryology</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila Proteins</topic><topic>Embryonic Structures - anatomy & histology</topic><topic>Embryonic Structures - physiology</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Helix-Loop-Helix Motifs</topic><topic>In Situ Hybridization</topic><topic>Mechanoreceptors - cytology</topic><topic>Mechanoreceptors - physiology</topic><topic>Morphogenesis - physiology</topic><topic>Mutation</topic><topic>Nerve Growth Factors - genetics</topic><topic>Nerve Growth Factors - metabolism</topic><topic>Nerve Tissue Proteins</topic><topic>Olfactory Receptor Neurons - cytology</topic><topic>Olfactory Receptor Neurons - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>zur Lage, Petra I</creatorcontrib><creatorcontrib>Prentice, David R A</creatorcontrib><creatorcontrib>Holohan, Eimear E</creatorcontrib><creatorcontrib>Jarman, Andrew P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>zur Lage, Petra I</au><au>Prentice, David R A</au><au>Holohan, Eimear E</au><au>Jarman, Andrew P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>130</volume><issue>19</issue><spage>4683</spage><epage>4693</epage><pages>4683-4693</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>Proneural genes encode basic-helix-loop-helix (bHLH) transcription factors required for neural precursor specification. 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| fulltext | fulltext |
| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 2003-10, Vol.130 (19), p.4683-4693 |
| issn | 0950-1991 1477-9129 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Animals Basic Helix-Loop-Helix Transcription Factors Cell Lineage DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila melanogaster - anatomy & histology Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila Proteins Embryonic Structures - anatomy & histology Embryonic Structures - physiology Gene Expression Regulation, Developmental Helix-Loop-Helix Motifs In Situ Hybridization Mechanoreceptors - cytology Mechanoreceptors - physiology Morphogenesis - physiology Mutation Nerve Growth Factors - genetics Nerve Growth Factors - metabolism Nerve Tissue Proteins Olfactory Receptor Neurons - cytology Olfactory Receptor Neurons - physiology |
| title | The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation |
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