Nocardial infection in patients infected with the human immunodeficiency virus
During the period 1981–2000, we diagnosed eight cases of HIV–Nocardia co-infection (0.38% of AIDS cases). Six were males, and the mean age was 28.6 years. The most common risk factor for HIV infection was intravenous drug abuse. Most patients were severely immunodepressed at the time of diagnosis (m...
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| Veröffentlicht in: | Clinical microbiology and infection 2003-07, Vol.9 (7), p.716-720 |
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| creator | Pintado, V. Gómez-Mampaso, E. Cobo, J. Quereda, C. Meseguer, M.A. Fortún, J. Navas, E. Moreno, S. |
| description | During the period 1981–2000, we diagnosed eight cases of HIV–Nocardia co-infection (0.38% of AIDS cases). Six were males, and the mean age was 28.6 years. The most common risk factor for HIV infection was intravenous drug abuse. Most patients were severely immunodepressed at the time of diagnosis (mean CD4+ count, 35 cells/μL). The clinical forms of nocardiosis seen were pulmonary infection in three, skin or soft tissue infection in three, disseminated in one, and pulmonary colonization in one. Most patients were given sulfonamides, and a clinical response was observed in six of seven treated patients. However, two patients with pulmonary disease died from progressive infection. Although its incidence is very low among AIDS patients, nocardiosis is associated with high morbidity and mortality among HIV-infected individuals. |
| doi_str_mv | 10.1046/j.1469-0691.2003.00588.x |
| format | Article |
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Six were males, and the mean age was 28.6 years. The most common risk factor for HIV infection was intravenous drug abuse. Most patients were severely immunodepressed at the time of diagnosis (mean CD4+ count, 35 cells/μL). The clinical forms of nocardiosis seen were pulmonary infection in three, skin or soft tissue infection in three, disseminated in one, and pulmonary colonization in one. Most patients were given sulfonamides, and a clinical response was observed in six of seven treated patients. However, two patients with pulmonary disease died from progressive infection. Although its incidence is very low among AIDS patients, nocardiosis is associated with high morbidity and mortality among HIV-infected individuals.</description><identifier>ISSN: 1198-743X</identifier><identifier>EISSN: 1469-0691</identifier><identifier>DOI: 10.1046/j.1469-0691.2003.00588.x</identifier><identifier>PMID: 12925115</identifier><language>eng</language><publisher>Oxford, UK: Elsevier Ltd</publisher><subject>Adult ; AIDS ; Anti-Infective Agents - pharmacology ; Biological and medical sciences ; Female ; HIV ; HIV Infections - complications ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Nocardia Infections - drug therapy ; Nocardia Infections - physiopathology ; Nocardia Infections - virology ; Nocardiosis ; Retrospective Studies ; Sulfonamides - pharmacology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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Six were males, and the mean age was 28.6 years. The most common risk factor for HIV infection was intravenous drug abuse. Most patients were severely immunodepressed at the time of diagnosis (mean CD4+ count, 35 cells/μL). The clinical forms of nocardiosis seen were pulmonary infection in three, skin or soft tissue infection in three, disseminated in one, and pulmonary colonization in one. Most patients were given sulfonamides, and a clinical response was observed in six of seven treated patients. However, two patients with pulmonary disease died from progressive infection. Although its incidence is very low among AIDS patients, nocardiosis is associated with high morbidity and mortality among HIV-infected individuals.</description><subject>Adult</subject><subject>AIDS</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nocardia Infections - drug therapy</subject><subject>Nocardia Infections - physiopathology</subject><subject>Nocardia Infections - virology</subject><subject>Nocardiosis</subject><subject>Retrospective Studies</subject><subject>Sulfonamides - pharmacology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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| ispartof | Clinical microbiology and infection, 2003-07, Vol.9 (7), p.716-720 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult AIDS Anti-Infective Agents - pharmacology Biological and medical sciences Female HIV HIV Infections - complications Human immunodeficiency virus Human viral diseases Humans Infectious diseases Male Medical sciences Middle Aged Nocardia Infections - drug therapy Nocardia Infections - physiopathology Nocardia Infections - virology Nocardiosis Retrospective Studies Sulfonamides - pharmacology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Nocardial infection in patients infected with the human immunodeficiency virus |
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