Molecular and genetic characterisation of the host-protective oncosphere antigens of taeniid cestode parasites
Highly effective recombinant vaccines have been developed against Taenia ovis infection in sheep, Taenia saginata infection in cattle, Taenia solium infection in pigs, Echinococcus granulosus and Echinococcus multilocularis infections in a variety of intermediate host species. These vaccines have be...
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| Veröffentlicht in: | International Journal for Parasitology 2003-09, Vol.33 (11), p.1207-1217 |
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| container_title | International Journal for Parasitology |
| container_volume | 33 |
| creator | Lightowlers, M.W Gauci, C.G Chow, C Drew, D.R Gauci, S.M Heath, D.D Jackson, D.C Dadley-Moore, D.L Read, A.J |
| description | Highly effective recombinant vaccines have been developed against
Taenia ovis infection in sheep,
Taenia saginata infection in cattle,
Taenia solium infection in pigs,
Echinococcus granulosus and
Echinococcus multilocularis infections in a variety of intermediate host species. These vaccines have been based on the identification and expression in
Escherichia coli of antigens derived from the oncosphere life cycle stage, contained within the parasites' eggs. Investigation of the molecular aspects of these proteins and the genes encoding them have revealed a number of common features, including the presence of a predicted secretory signal sequence, and one or two copies of a fibronectin type III domain, each encoded by separate exons within the associated gene. Evidence has been obtained to confirm glycosylation of some of these antigens. Ongoing investigations will shed light on the biological roles played by the proteins within the parasites and the mechanism by which they make the parasites vulnerable to vaccine-induced immune responses. |
| doi_str_mv | 10.1016/S0020-7519(03)00174-7 |
| format | Article |
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Taenia ovis infection in sheep,
Taenia saginata infection in cattle,
Taenia solium infection in pigs,
Echinococcus granulosus and
Echinococcus multilocularis infections in a variety of intermediate host species. These vaccines have been based on the identification and expression in
Escherichia coli of antigens derived from the oncosphere life cycle stage, contained within the parasites' eggs. Investigation of the molecular aspects of these proteins and the genes encoding them have revealed a number of common features, including the presence of a predicted secretory signal sequence, and one or two copies of a fibronectin type III domain, each encoded by separate exons within the associated gene. Evidence has been obtained to confirm glycosylation of some of these antigens. Ongoing investigations will shed light on the biological roles played by the proteins within the parasites and the mechanism by which they make the parasites vulnerable to vaccine-induced immune responses.</description><identifier>ISSN: 0020-7519</identifier><identifier>EISSN: 1879-0135</identifier><identifier>DOI: 10.1016/S0020-7519(03)00174-7</identifier><identifier>PMID: 13678636</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Antigens, Helminth - genetics ; Antigens, Helminth - immunology ; Cattle ; Cattle Diseases - prevention & control ; Cysticercosis ; Echinococcosis - prevention & control ; Echinococcus ; Epitopes ; Fibronectin domain ; Gene structure ; Genes, Helminth ; Glycosylation ; Host-Parasite Interactions ; Hydatid ; Ovum - immunology ; Reverse Transcriptase Polymerase Chain Reaction ; RNA Splicing ; Sheep ; Sheep Diseases - prevention & control ; Swine ; Swine Diseases - prevention & control ; Taenia ; Taenia - genetics ; Taenia - immunology ; Taeniasis - prevention & control ; Vaccine ; Vaccines, Synthetic - therapeutic use</subject><ispartof>International Journal for Parasitology, 2003-09, Vol.33 (11), p.1207-1217</ispartof><rights>2003 Australian Society for Parasitology Inc</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-3d1476eb3ff949c8ca1f934813ce8913b78e0133e592c679de80ae2bde1fcd223</citedby><cites>FETCH-LOGICAL-c392t-3d1476eb3ff949c8ca1f934813ce8913b78e0133e592c679de80ae2bde1fcd223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0020751903001747$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,776,780,788,3537,27899,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13678636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lightowlers, M.W</creatorcontrib><creatorcontrib>Gauci, C.G</creatorcontrib><creatorcontrib>Chow, C</creatorcontrib><creatorcontrib>Drew, D.R</creatorcontrib><creatorcontrib>Gauci, S.M</creatorcontrib><creatorcontrib>Heath, D.D</creatorcontrib><creatorcontrib>Jackson, D.C</creatorcontrib><creatorcontrib>Dadley-Moore, D.L</creatorcontrib><creatorcontrib>Read, A.J</creatorcontrib><title>Molecular and genetic characterisation of the host-protective oncosphere antigens of taeniid cestode parasites</title><title>International Journal for Parasitology</title><addtitle>Int J Parasitol</addtitle><description>Highly effective recombinant vaccines have been developed against
Taenia ovis infection in sheep,
Taenia saginata infection in cattle,
Taenia solium infection in pigs,
Echinococcus granulosus and
Echinococcus multilocularis infections in a variety of intermediate host species. These vaccines have been based on the identification and expression in
Escherichia coli of antigens derived from the oncosphere life cycle stage, contained within the parasites' eggs. Investigation of the molecular aspects of these proteins and the genes encoding them have revealed a number of common features, including the presence of a predicted secretory signal sequence, and one or two copies of a fibronectin type III domain, each encoded by separate exons within the associated gene. Evidence has been obtained to confirm glycosylation of some of these antigens. Ongoing investigations will shed light on the biological roles played by the proteins within the parasites and the mechanism by which they make the parasites vulnerable to vaccine-induced immune responses.</description><subject>Animals</subject><subject>Antigens, Helminth - genetics</subject><subject>Antigens, Helminth - immunology</subject><subject>Cattle</subject><subject>Cattle Diseases - prevention & control</subject><subject>Cysticercosis</subject><subject>Echinococcosis - prevention & control</subject><subject>Echinococcus</subject><subject>Epitopes</subject><subject>Fibronectin domain</subject><subject>Gene structure</subject><subject>Genes, Helminth</subject><subject>Glycosylation</subject><subject>Host-Parasite Interactions</subject><subject>Hydatid</subject><subject>Ovum - immunology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA Splicing</subject><subject>Sheep</subject><subject>Sheep Diseases - prevention & control</subject><subject>Swine</subject><subject>Swine Diseases - prevention & control</subject><subject>Taenia</subject><subject>Taenia - genetics</subject><subject>Taenia - immunology</subject><subject>Taeniasis - prevention & control</subject><subject>Vaccine</subject><subject>Vaccines, Synthetic - therapeutic use</subject><issn>0020-7519</issn><issn>1879-0135</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTtvGzEQhAkjRizL-QkOWAVxcTZ5vDuSVWAIfgEyXCSuCWq5FzE4HRWSMpB_b-qBuFS1zTc7uzOEXHJ2zRnvbn4yVrNKtlx_Z-KKMS6bSp6QCVdSV4yL9hOZ_EfOyHlKfwrUiqb5TM646KTqRDch43MYEDaDjdSOjv7GEbMHCksbLWSMPtnsw0hDT_MS6TKkXK1jyAjZvyENI4S0XmLEIs--yNMOtTh67yhgysEhXZdtyWdMF-S0t0PCL4c5Ja_3d79mj9X85eFpdjuvQOg6V8LxRna4EH2vGw0KLO-1aBQXgEpzsZAKy48CW11DJ7VDxSzWC4e8B1fXYkq-7feWW_9uyhVm5RPgMNgRwyYZKdpO1yWOYyBXqtOsYQVs9yDEkFLE3qyjX9n4z3Bmto2YXSNmG7dhwuwaKT5T8vVgsFms0H2oDhUU4McewJLHm8doEngcAZ2PJWXjgj9i8Q7h-p0U</recordid><startdate>20030930</startdate><enddate>20030930</enddate><creator>Lightowlers, M.W</creator><creator>Gauci, C.G</creator><creator>Chow, C</creator><creator>Drew, D.R</creator><creator>Gauci, S.M</creator><creator>Heath, D.D</creator><creator>Jackson, D.C</creator><creator>Dadley-Moore, D.L</creator><creator>Read, A.J</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030930</creationdate><title>Molecular and genetic characterisation of the host-protective oncosphere antigens of taeniid cestode parasites</title><author>Lightowlers, M.W ; 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Taenia ovis infection in sheep,
Taenia saginata infection in cattle,
Taenia solium infection in pigs,
Echinococcus granulosus and
Echinococcus multilocularis infections in a variety of intermediate host species. These vaccines have been based on the identification and expression in
Escherichia coli of antigens derived from the oncosphere life cycle stage, contained within the parasites' eggs. Investigation of the molecular aspects of these proteins and the genes encoding them have revealed a number of common features, including the presence of a predicted secretory signal sequence, and one or two copies of a fibronectin type III domain, each encoded by separate exons within the associated gene. Evidence has been obtained to confirm glycosylation of some of these antigens. Ongoing investigations will shed light on the biological roles played by the proteins within the parasites and the mechanism by which they make the parasites vulnerable to vaccine-induced immune responses.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>13678636</pmid><doi>10.1016/S0020-7519(03)00174-7</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antigens, Helminth - genetics Antigens, Helminth - immunology Cattle Cattle Diseases - prevention & control Cysticercosis Echinococcosis - prevention & control Echinococcus Epitopes Fibronectin domain Gene structure Genes, Helminth Glycosylation Host-Parasite Interactions Hydatid Ovum - immunology Reverse Transcriptase Polymerase Chain Reaction RNA Splicing Sheep Sheep Diseases - prevention & control Swine Swine Diseases - prevention & control Taenia Taenia - genetics Taenia - immunology Taeniasis - prevention & control Vaccine Vaccines, Synthetic - therapeutic use |
| title | Molecular and genetic characterisation of the host-protective oncosphere antigens of taeniid cestode parasites |
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