Epicutaneous Immunization with Autoantigenic Peptides Induces T Suppressor Cells that Prevent Experimental Allergic Encephalomyelitis

Information on how suppressor/regulatory T cells can be generated directly in vivo and prevent autoimmunity remains fragmentary. We show here that epicutaneous immunization (ECi) with the immunodominant peptide of myelin basic protein (MBP), Ac1-11, protects mice that are transgenic for an Ac1-11-sp...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2003-09, Vol.19 (3), p.317-328
Hauptverfasser:	Bynoe, Margaret S., Evans, J.Tori, Viret, Christophe, Janeway, Charles A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantigens - administration & dosage Autoantigens - immunology CD25 antigen CD4 antigen Cell Division - physiology Cytokines Cytokines - metabolism Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - prevention & control Experiments Immune system Interferon-gamma - metabolism Lymphocytes Medical research Mice myelin basic protein Peptides Peptides - administration & dosage Peptides - immunology Proteins Receptors, Interleukin-2 - metabolism Rodents T-Lymphocytes, Regulatory - immunology Th2 Cells - metabolism Vaccination
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