HRT1 modulates vascular smooth muscle cell proliferation and apoptosis

The Notch signaling pathway plays vital roles in vascular development and homeostasis. However, the functional role of HRT1, a primary downstream effector of Notch signaling in VSMC, is poorly characterized. In the present study, we postulated that HRT1 plays fundamental roles in modulating VSMC fat...

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Veröffentlicht in:	Biochemical and biophysical research communications 2003-08, Vol.308 (3), p.596-601
Hauptverfasser:	Wang, Wenli, Prince, Chengyu Z, Hu, Xing, Pollman, Matthew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Basic Helix-Loop-Helix Transcription Factors Cell Division Cell Line Cell Survival Cells, Cultured Cyclin-Dependent Kinase Inhibitor p21 Cyclins - metabolism HRT1 Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Proliferation Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Rats Repressor Proteins - physiology Signal Transduction VSMC
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