Central Nervous System–Targeted Complement Inhibition Mediates Neuroprotection after Closed Head Injury in Transgenic Mice

The role of intracerebral complement activation after traumatic brain injury remains unclear. In this study, the authors demonstrate that transgenic mice with astrocyte-targeted expression of the soluble complement inhibitor sCrry have a significantly reduced neurologic impairment and improved blood...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2003-09, Vol.23 (9), p.1070-1074
Hauptverfasser:	Rancan, Mario, Morganti-Kossmann, Maria C., Barnum, Scott R., Saft, Silvia, Schmidt, Oliver I., Ertel, Wolfgang, Stahel, Philip F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - physiology Biological and medical sciences Blood-Brain Barrier - physiology Brain - pathology Brain - physiopathology Central Nervous System - immunology Complement Activation Complement System Proteins - immunology Head Injuries, Closed - immunology Head Injuries, Closed - pathology Head Injuries, Closed - physiopathology Injuries of the nervous system and the skull. Diseases due to physical agents Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Neuroprotective Agents - metabolism Receptors, Complement - genetics Receptors, Complement - metabolism Traumas. Diseases due to physical agents
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