Central Nervous System–Targeted Complement Inhibition Mediates Neuroprotection after Closed Head Injury in Transgenic Mice
The role of intracerebral complement activation after traumatic brain injury remains unclear. In this study, the authors demonstrate that transgenic mice with astrocyte-targeted expression of the soluble complement inhibitor sCrry have a significantly reduced neurologic impairment and improved blood...
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| Veröffentlicht in: | Journal of cerebral blood flow and metabolism 2003-09, Vol.23 (9), p.1070-1074 |
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| container_title | Journal of cerebral blood flow and metabolism |
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| creator | Rancan, Mario Morganti-Kossmann, Maria C. Barnum, Scott R. Saft, Silvia Schmidt, Oliver I. Ertel, Wolfgang Stahel, Philip F. |
| description | The role of intracerebral complement activation after traumatic brain injury remains unclear. In this study, the authors demonstrate that transgenic mice with astrocyte-targeted expression of the soluble complement inhibitor sCrry have a significantly reduced neurologic impairment and improved blood–brain barrier function after closed head injury compared with wild-type C57BL/6 littermates. This work further implicates the complement system as a participant in secondary progression of brain damage after head trauma and provides a strong rationale for future studies of posttraumatic pharmacologic complement inhibition. |
| doi_str_mv | 10.1097/01.WCB.0000084250.20114.2C |
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In this study, the authors demonstrate that transgenic mice with astrocyte-targeted expression of the soluble complement inhibitor sCrry have a significantly reduced neurologic impairment and improved blood–brain barrier function after closed head injury compared with wild-type C57BL/6 littermates. This work further implicates the complement system as a participant in secondary progression of brain damage after head trauma and provides a strong rationale for future studies of posttraumatic pharmacologic complement inhibition.</description><identifier>ISSN: 0271-678X</identifier><identifier>EISSN: 1559-7016</identifier><identifier>DOI: 10.1097/01.WCB.0000084250.20114.2C</identifier><identifier>PMID: 12973023</identifier><identifier>CODEN: JCBMDN</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Behavior, Animal - physiology ; Biological and medical sciences ; Blood-Brain Barrier - physiology ; Brain - pathology ; Brain - physiopathology ; Central Nervous System - immunology ; Complement Activation ; Complement System Proteins - immunology ; Head Injuries, Closed - immunology ; Head Injuries, Closed - pathology ; Head Injuries, Closed - physiopathology ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neuroprotective Agents - metabolism ; Receptors, Complement - genetics ; Receptors, Complement - metabolism ; Traumas. Diseases due to physical agents</subject><ispartof>Journal of cerebral blood flow and metabolism, 2003-09, Vol.23 (9), p.1070-1074</ispartof><rights>2003 The International Society for Cerebral Blood Flow and Metabolism</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Sep 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-b31d812985bcc87a0af9a730a1ab30fc0c350993febf2da7344f785dd3b7777a3</citedby><cites>FETCH-LOGICAL-c529t-b31d812985bcc87a0af9a730a1ab30fc0c350993febf2da7344f785dd3b7777a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1097/01.WCB.0000084250.20114.2C$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1097/01.WCB.0000084250.20114.2C$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15097380$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12973023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rancan, Mario</creatorcontrib><creatorcontrib>Morganti-Kossmann, Maria C.</creatorcontrib><creatorcontrib>Barnum, Scott R.</creatorcontrib><creatorcontrib>Saft, Silvia</creatorcontrib><creatorcontrib>Schmidt, Oliver I.</creatorcontrib><creatorcontrib>Ertel, Wolfgang</creatorcontrib><creatorcontrib>Stahel, Philip F.</creatorcontrib><title>Central Nervous System–Targeted Complement Inhibition Mediates Neuroprotection after Closed Head Injury in Transgenic Mice</title><title>Journal of cerebral blood flow and metabolism</title><addtitle>J Cereb Blood Flow Metab</addtitle><description>The role of intracerebral complement activation after traumatic brain injury remains unclear. In this study, the authors demonstrate that transgenic mice with astrocyte-targeted expression of the soluble complement inhibitor sCrry have a significantly reduced neurologic impairment and improved blood–brain barrier function after closed head injury compared with wild-type C57BL/6 littermates. This work further implicates the complement system as a participant in secondary progression of brain damage after head trauma and provides a strong rationale for future studies of posttraumatic pharmacologic complement inhibition.</description><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier - physiology</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Central Nervous System - immunology</subject><subject>Complement Activation</subject><subject>Complement System Proteins - immunology</subject><subject>Head Injuries, Closed - immunology</subject><subject>Head Injuries, Closed - pathology</subject><subject>Head Injuries, Closed - physiopathology</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Neuroprotective Agents - metabolism</subject><subject>Receptors, Complement - genetics</subject><subject>Receptors, Complement - metabolism</subject><subject>Traumas. 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Diseases due to physical agents</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>Neuroprotective Agents - metabolism</topic><topic>Receptors, Complement - genetics</topic><topic>Receptors, Complement - metabolism</topic><topic>Traumas. 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| identifier | ISSN: 0271-678X |
| ispartof | Journal of cerebral blood flow and metabolism, 2003-09, Vol.23 (9), p.1070-1074 |
| issn | 0271-678X 1559-7016 |
| language | eng |
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| subjects | Animals Behavior, Animal - physiology Biological and medical sciences Blood-Brain Barrier - physiology Brain - pathology Brain - physiopathology Central Nervous System - immunology Complement Activation Complement System Proteins - immunology Head Injuries, Closed - immunology Head Injuries, Closed - pathology Head Injuries, Closed - physiopathology Injuries of the nervous system and the skull. Diseases due to physical agents Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Neuroprotective Agents - metabolism Receptors, Complement - genetics Receptors, Complement - metabolism Traumas. Diseases due to physical agents |
| title | Central Nervous System–Targeted Complement Inhibition Mediates Neuroprotection after Closed Head Injury in Transgenic Mice |
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