Effects of Dehydroepiandrosterone-sulfate on the Apo E Genotype Influence on Plasma Lipid Levels in Prepubertal Children
Gender differences in the apolipoprotein (apo) E genotype effect on plasma lipid levels reported in adults have also been found in pre-pubertal children. In adults, the difference seems to be due to the influence of sexual hormones. The reason why this difference exits between pre-pubertal girls and...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2003-08, Vol.88 (8), p.3997-4000 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Garcés, Carmen Benavente, Mercedes Cano, Beatriz Viturro, Enrique Ortega, Henar Horcajada, Cristina De Oya, Manuel |
| description | Gender differences in the apolipoprotein (apo) E genotype effect on
plasma lipid levels reported in adults have also been found in
pre-pubertal children. In adults, the difference seems to be due to the
influence of sexual hormones. The reason why this difference exits
between pre-pubertal girls and boys, for whom those sexual hormones are
not different, is unclear. However, there is an important difference in
Dehydroepiandrosterone-sulfate (DHEA-S) levels between pre-pubertal
boys and girls. To evaluate the influence of DHEA-S on apo E genetic
determinants of plasma lipids levels in pre-pubertal children we
measured plasma DHEA-S in 1045 healthy children (534 males and 511
females) 6 to 8 years old in which a different apoE influence on lipid
levels had been reported between girls and boys. Our observations
demonstrate that the extent of the lipid increasing or decreasing
effects associated with each allele were modulated by DHEA-S. DHEA-S
increases the hypolipemic effect of the ε2 allele and decreases the
hyperlipemic effect of the ε4 allele. In conclusion, the interaction
of apo E genotype and DHEA-S may represent a critical determinant of
TC, LDL-C and apo B levels in children at the prepuberal age. |
| doi_str_mv | 10.1210/jc.2003-030459 |
| format | Article |
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plasma lipid levels reported in adults have also been found in
pre-pubertal children. In adults, the difference seems to be due to the
influence of sexual hormones. The reason why this difference exits
between pre-pubertal girls and boys, for whom those sexual hormones are
not different, is unclear. However, there is an important difference in
Dehydroepiandrosterone-sulfate (DHEA-S) levels between pre-pubertal
boys and girls. To evaluate the influence of DHEA-S on apo E genetic
determinants of plasma lipids levels in pre-pubertal children we
measured plasma DHEA-S in 1045 healthy children (534 males and 511
females) 6 to 8 years old in which a different apoE influence on lipid
levels had been reported between girls and boys. Our observations
demonstrate that the extent of the lipid increasing or decreasing
effects associated with each allele were modulated by DHEA-S. DHEA-S
increases the hypolipemic effect of the ε2 allele and decreases the
hyperlipemic effect of the ε4 allele. In conclusion, the interaction
of apo E genotype and DHEA-S may represent a critical determinant of
TC, LDL-C and apo B levels in children at the prepuberal age.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2003-030459</identifier><identifier>PMID: 12915699</identifier><language>eng</language><publisher>United States: Endocrine Society</publisher><subject>Apolipoproteins E - genetics ; Body Height - physiology ; Body Weight - physiology ; Child ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cohort Studies ; Dehydroepiandrosterone Sulfate - blood ; Dehydroepiandrosterone Sulfate - pharmacology ; Female ; Genotype ; Humans ; Linear Models ; Lipids - blood ; Male ; Puberty - physiology ; Sex Characteristics ; Spain</subject><ispartof>The journal of clinical endocrinology and metabolism, 2003-08, Vol.88 (8), p.3997-4000</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-2902e149911e4371a6ec0aab5164e87fed720812c39885e42094c216258dfc4a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12915699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcés, Carmen</creatorcontrib><creatorcontrib>Benavente, Mercedes</creatorcontrib><creatorcontrib>Cano, Beatriz</creatorcontrib><creatorcontrib>Viturro, Enrique</creatorcontrib><creatorcontrib>Ortega, Henar</creatorcontrib><creatorcontrib>Horcajada, Cristina</creatorcontrib><creatorcontrib>De Oya, Manuel</creatorcontrib><title>Effects of Dehydroepiandrosterone-sulfate on the Apo E Genotype Influence on Plasma Lipid Levels in Prepubertal Children</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Gender differences in the apolipoprotein (apo) E genotype effect on
plasma lipid levels reported in adults have also been found in
pre-pubertal children. In adults, the difference seems to be due to the
influence of sexual hormones. The reason why this difference exits
between pre-pubertal girls and boys, for whom those sexual hormones are
not different, is unclear. However, there is an important difference in
Dehydroepiandrosterone-sulfate (DHEA-S) levels between pre-pubertal
boys and girls. To evaluate the influence of DHEA-S on apo E genetic
determinants of plasma lipids levels in pre-pubertal children we
measured plasma DHEA-S in 1045 healthy children (534 males and 511
females) 6 to 8 years old in which a different apoE influence on lipid
levels had been reported between girls and boys. Our observations
demonstrate that the extent of the lipid increasing or decreasing
effects associated with each allele were modulated by DHEA-S. DHEA-S
increases the hypolipemic effect of the ε2 allele and decreases the
hyperlipemic effect of the ε4 allele. In conclusion, the interaction
of apo E genotype and DHEA-S may represent a critical determinant of
TC, LDL-C and apo B levels in children at the prepuberal age.</description><subject>Apolipoproteins E - genetics</subject><subject>Body Height - physiology</subject><subject>Body Weight - physiology</subject><subject>Child</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Cohort Studies</subject><subject>Dehydroepiandrosterone Sulfate - blood</subject><subject>Dehydroepiandrosterone Sulfate - pharmacology</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Puberty - physiology</subject><subject>Sex Characteristics</subject><subject>Spain</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFrGzEQRkVpaZy01x6LTr2to9FKq9UxOG4SMCSHFnoTsnaE18jSVtot8b_PpjbklNMHM28-mEfIN2BL4MCu927JGasrVjMh9QeyAC1kpUCrj2TBGIdKK_7nglyWsmcMhJD1Z3IBXINstF6Q57X36MZCk6e3uDt2OeHQ2zhnGTGniFWZgrcj0hTpuEN6MyS6pncY03gckD5EHyaM7v_-KdhysHTTD31HN_gPQ6H9PM44TFvMow10tetDlzF-IZ-8DQW_nvOK_P65_rW6rzaPdw-rm03laqXGimvGEYTWAChqBbZBx6zdSmgEtspjpzhrgbtat61EwZkWjkPDZdt5J2x9RX6ceoec_k5YRnPoi8MQbMQ0FaNq2Qgu2AwuT6CbXy8ZvRlyf7D5aICZV9dm78yra3NyPR98PzdP2wN2b_hZ7gzIE4CxSy73EYeMpZh9mnKcf36v-AWUYIvR</recordid><startdate>200308</startdate><enddate>200308</enddate><creator>Garcés, Carmen</creator><creator>Benavente, Mercedes</creator><creator>Cano, Beatriz</creator><creator>Viturro, Enrique</creator><creator>Ortega, Henar</creator><creator>Horcajada, Cristina</creator><creator>De Oya, Manuel</creator><general>Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200308</creationdate><title>Effects of Dehydroepiandrosterone-sulfate on the Apo E Genotype Influence on Plasma Lipid Levels in Prepubertal Children</title><author>Garcés, Carmen ; Benavente, Mercedes ; Cano, Beatriz ; Viturro, Enrique ; Ortega, Henar ; Horcajada, Cristina ; De Oya, Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-2902e149911e4371a6ec0aab5164e87fed720812c39885e42094c216258dfc4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Apolipoproteins E - genetics</topic><topic>Body Height - physiology</topic><topic>Body Weight - physiology</topic><topic>Child</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Cohort Studies</topic><topic>Dehydroepiandrosterone Sulfate - blood</topic><topic>Dehydroepiandrosterone Sulfate - pharmacology</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Puberty - physiology</topic><topic>Sex Characteristics</topic><topic>Spain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcés, Carmen</creatorcontrib><creatorcontrib>Benavente, Mercedes</creatorcontrib><creatorcontrib>Cano, Beatriz</creatorcontrib><creatorcontrib>Viturro, Enrique</creatorcontrib><creatorcontrib>Ortega, Henar</creatorcontrib><creatorcontrib>Horcajada, Cristina</creatorcontrib><creatorcontrib>De Oya, Manuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcés, Carmen</au><au>Benavente, Mercedes</au><au>Cano, Beatriz</au><au>Viturro, Enrique</au><au>Ortega, Henar</au><au>Horcajada, Cristina</au><au>De Oya, Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Dehydroepiandrosterone-sulfate on the Apo E Genotype Influence on Plasma Lipid Levels in Prepubertal Children</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2003-08</date><risdate>2003</risdate><volume>88</volume><issue>8</issue><spage>3997</spage><epage>4000</epage><pages>3997-4000</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Gender differences in the apolipoprotein (apo) E genotype effect on
plasma lipid levels reported in adults have also been found in
pre-pubertal children. In adults, the difference seems to be due to the
influence of sexual hormones. The reason why this difference exits
between pre-pubertal girls and boys, for whom those sexual hormones are
not different, is unclear. However, there is an important difference in
Dehydroepiandrosterone-sulfate (DHEA-S) levels between pre-pubertal
boys and girls. To evaluate the influence of DHEA-S on apo E genetic
determinants of plasma lipids levels in pre-pubertal children we
measured plasma DHEA-S in 1045 healthy children (534 males and 511
females) 6 to 8 years old in which a different apoE influence on lipid
levels had been reported between girls and boys. Our observations
demonstrate that the extent of the lipid increasing or decreasing
effects associated with each allele were modulated by DHEA-S. DHEA-S
increases the hypolipemic effect of the ε2 allele and decreases the
hyperlipemic effect of the ε4 allele. In conclusion, the interaction
of apo E genotype and DHEA-S may represent a critical determinant of
TC, LDL-C and apo B levels in children at the prepuberal age.</abstract><cop>United States</cop><pub>Endocrine Society</pub><pmid>12915699</pmid><doi>10.1210/jc.2003-030459</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Apolipoproteins E - genetics Body Height - physiology Body Weight - physiology Child Cholesterol, HDL - blood Cholesterol, LDL - blood Cohort Studies Dehydroepiandrosterone Sulfate - blood Dehydroepiandrosterone Sulfate - pharmacology Female Genotype Humans Linear Models Lipids - blood Male Puberty - physiology Sex Characteristics Spain |
| title | Effects of Dehydroepiandrosterone-sulfate on the Apo E Genotype Influence on Plasma Lipid Levels in Prepubertal Children |
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