Caffeine increases spinal excitability in humans
The Hoffman reflex (H reflex) has long been established as a measure of spinal excitability. Caffeine is one of the most widely consumed drugs in the world. Because it is known to increase excitatory neurotransmission, we hypothesized that caffeine would increase spinal excitability and thus alter t...
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| Veröffentlicht in: | Muscle & nerve 2003-09, Vol.28 (3), p.359-364 |
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| creator | Walton, C. Kalmar, J. Cafarelli, E. |
| description | The Hoffman reflex (H reflex) has long been established as a measure of spinal excitability. Caffeine is one of the most widely consumed drugs in the world. Because it is known to increase excitatory neurotransmission, we hypothesized that caffeine would increase spinal excitability and thus alter the H reflex by increasing its amplitude. Seven subjects each attended the laboratory on 2 days. Caffeine (6 mg/kg) was administered on one day and a placebo was administered on the other. The tibial nerve was stimulated at incremental intensities to create an H‐reflex recruitment curve prior to capsule administration (pretest) and 1 h later (posttest) on each day. The slope of H‐reflex recruitment curve normalized to that of the M wave (Hslp/Mslp) was compared (pretest to posttest). Caffeine increased spinal excitability 43 ± 17% (P < 0.05). Thus, caffeine may be used to safely increase spinal excitability in electrophysiological studies of the human neuromuscular system. Our results also suggest that caffeine intake should be controlled when the H reflex is used in diagnostic and experimental situations. Muscle Nerve 28: 359–364, 2003 |
| doi_str_mv | 10.1002/mus.10457 |
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Caffeine is one of the most widely consumed drugs in the world. Because it is known to increase excitatory neurotransmission, we hypothesized that caffeine would increase spinal excitability and thus alter the H reflex by increasing its amplitude. Seven subjects each attended the laboratory on 2 days. Caffeine (6 mg/kg) was administered on one day and a placebo was administered on the other. The tibial nerve was stimulated at incremental intensities to create an H‐reflex recruitment curve prior to capsule administration (pretest) and 1 h later (posttest) on each day. The slope of H‐reflex recruitment curve normalized to that of the M wave (Hslp/Mslp) was compared (pretest to posttest). Caffeine increased spinal excitability 43 ± 17% (P < 0.05). Thus, caffeine may be used to safely increase spinal excitability in electrophysiological studies of the human neuromuscular system. Our results also suggest that caffeine intake should be controlled when the H reflex is used in diagnostic and experimental situations. Muscle Nerve 28: 359–364, 2003</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.10457</identifier><identifier>PMID: 12929197</identifier><identifier>CODEN: MUNEDE</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Action Potentials - drug effects ; Action Potentials - physiology ; Adult ; Biological and medical sciences ; caffeine ; Caffeine - pharmacology ; Central Nervous System Stimulants - pharmacology ; Electric Stimulation ; Electromyography - drug effects ; Excitatory Postsynaptic Potentials - drug effects ; Excitatory Postsynaptic Potentials - physiology ; Fundamental and applied biological sciences. Psychology ; H-reflex ; H-Reflex - drug effects ; H-Reflex - physiology ; Humans ; Male ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Muscle Contraction - drug effects ; Muscle Contraction - physiology ; Neurons - drug effects ; Neurons - physiology ; recruitment curve ; soleus ; Spinal Cord - drug effects ; Spinal Cord - physiology ; spinal excitability ; Synaptic Transmission - drug effects ; Synaptic Transmission - physiology ; Up-Regulation - drug effects ; Up-Regulation - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Muscle & nerve, 2003-09, Vol.28 (3), p.359-364</ispartof><rights>Copyright © 2003 Wiley Periodicals, Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3897-199d0ac4759f199c8f3d9b23eb0e6597f0c3f578c1c44afe733bc01dccc5cdb03</citedby><cites>FETCH-LOGICAL-c3897-199d0ac4759f199c8f3d9b23eb0e6597f0c3f578c1c44afe733bc01dccc5cdb03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.10457$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.10457$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15071667$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12929197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walton, C.</creatorcontrib><creatorcontrib>Kalmar, J.</creatorcontrib><creatorcontrib>Cafarelli, E.</creatorcontrib><title>Caffeine increases spinal excitability in humans</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>The Hoffman reflex (H reflex) has long been established as a measure of spinal excitability. Caffeine is one of the most widely consumed drugs in the world. Because it is known to increase excitatory neurotransmission, we hypothesized that caffeine would increase spinal excitability and thus alter the H reflex by increasing its amplitude. Seven subjects each attended the laboratory on 2 days. Caffeine (6 mg/kg) was administered on one day and a placebo was administered on the other. The tibial nerve was stimulated at incremental intensities to create an H‐reflex recruitment curve prior to capsule administration (pretest) and 1 h later (posttest) on each day. The slope of H‐reflex recruitment curve normalized to that of the M wave (Hslp/Mslp) was compared (pretest to posttest). Caffeine increased spinal excitability 43 ± 17% (P < 0.05). Thus, caffeine may be used to safely increase spinal excitability in electrophysiological studies of the human neuromuscular system. Our results also suggest that caffeine intake should be controlled when the H reflex is used in diagnostic and experimental situations. Muscle Nerve 28: 359–364, 2003</description><subject>Action Potentials - drug effects</subject><subject>Action Potentials - physiology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>caffeine</subject><subject>Caffeine - pharmacology</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Electric Stimulation</subject><subject>Electromyography - drug effects</subject><subject>Excitatory Postsynaptic Potentials - drug effects</subject><subject>Excitatory Postsynaptic Potentials - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>H-reflex</subject><subject>H-Reflex - drug effects</subject><subject>H-Reflex - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle Contraction - physiology</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>recruitment curve</subject><subject>soleus</subject><subject>Spinal Cord - drug effects</subject><subject>Spinal Cord - physiology</subject><subject>spinal excitability</subject><subject>Synaptic Transmission - drug effects</subject><subject>Synaptic Transmission - physiology</subject><subject>Up-Regulation - drug effects</subject><subject>Up-Regulation - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFOwzAQRC0EoqVw4AdQLyBxCLXrOI6PKIKCVIpEqejNcja2MCRpsRPR_j0uLXDitCPtm9nVIHRK8BXBeDioWh9EzPge6hIseBQzke6jLiZxGiVUzDvoyPs3jDFJE36IOmQohoII3kU4U8ZoW-u-rcFp5bXv-6WtVdnXK7CNym1pm3XY9l_bStX-GB0YVXp9sps9NLu9ec7uovHj6D67HkdA0_ABEaLACmLOhAkaUkMLkQ-pzrFOmOAGAzWMp0AgjpXRnNIcMCkAgEGRY9pDF9vcpVt8tNo3srIedFmqWi9aLzllCeUxC-DlFgS38N5pI5fOVsqtJcFyU48M9cjvegJ7tgtt80oXf-SujwCc7wDlQZXGqRqs_-MY5iRJNtxgy33aUq__vygfZtOf09HWYX2jV78O5d5lyONMvkxGcv40TSfZmMg5_QK8fIsY</recordid><startdate>200309</startdate><enddate>200309</enddate><creator>Walton, C.</creator><creator>Kalmar, J.</creator><creator>Cafarelli, E.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200309</creationdate><title>Caffeine increases spinal excitability in humans</title><author>Walton, C. ; Kalmar, J. ; Cafarelli, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3897-199d0ac4759f199c8f3d9b23eb0e6597f0c3f578c1c44afe733bc01dccc5cdb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Action Potentials - drug effects</topic><topic>Action Potentials - physiology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>caffeine</topic><topic>Caffeine - pharmacology</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Electric Stimulation</topic><topic>Electromyography - drug effects</topic><topic>Excitatory Postsynaptic Potentials - drug effects</topic><topic>Excitatory Postsynaptic Potentials - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>H-reflex</topic><topic>H-Reflex - drug effects</topic><topic>H-Reflex - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle Contraction - physiology</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>recruitment curve</topic><topic>soleus</topic><topic>Spinal Cord - drug effects</topic><topic>Spinal Cord - physiology</topic><topic>spinal excitability</topic><topic>Synaptic Transmission - drug effects</topic><topic>Synaptic Transmission - physiology</topic><topic>Up-Regulation - drug effects</topic><topic>Up-Regulation - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walton, C.</creatorcontrib><creatorcontrib>Kalmar, J.</creatorcontrib><creatorcontrib>Cafarelli, E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walton, C.</au><au>Kalmar, J.</au><au>Cafarelli, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caffeine increases spinal excitability in humans</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2003-09</date><risdate>2003</risdate><volume>28</volume><issue>3</issue><spage>359</spage><epage>364</epage><pages>359-364</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><coden>MUNEDE</coden><abstract>The Hoffman reflex (H reflex) has long been established as a measure of spinal excitability. Caffeine is one of the most widely consumed drugs in the world. Because it is known to increase excitatory neurotransmission, we hypothesized that caffeine would increase spinal excitability and thus alter the H reflex by increasing its amplitude. Seven subjects each attended the laboratory on 2 days. Caffeine (6 mg/kg) was administered on one day and a placebo was administered on the other. The tibial nerve was stimulated at incremental intensities to create an H‐reflex recruitment curve prior to capsule administration (pretest) and 1 h later (posttest) on each day. The slope of H‐reflex recruitment curve normalized to that of the M wave (Hslp/Mslp) was compared (pretest to posttest). Caffeine increased spinal excitability 43 ± 17% (P < 0.05). Thus, caffeine may be used to safely increase spinal excitability in electrophysiological studies of the human neuromuscular system. Our results also suggest that caffeine intake should be controlled when the H reflex is used in diagnostic and experimental situations. Muscle Nerve 28: 359–364, 2003</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12929197</pmid><doi>10.1002/mus.10457</doi><tpages>6</tpages></addata></record> |
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| subjects | Action Potentials - drug effects Action Potentials - physiology Adult Biological and medical sciences caffeine Caffeine - pharmacology Central Nervous System Stimulants - pharmacology Electric Stimulation Electromyography - drug effects Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Fundamental and applied biological sciences. Psychology H-reflex H-Reflex - drug effects H-Reflex - physiology Humans Male Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Muscle Contraction - drug effects Muscle Contraction - physiology Neurons - drug effects Neurons - physiology recruitment curve soleus Spinal Cord - drug effects Spinal Cord - physiology spinal excitability Synaptic Transmission - drug effects Synaptic Transmission - physiology Up-Regulation - drug effects Up-Regulation - physiology Vertebrates: nervous system and sense organs |
| title | Caffeine increases spinal excitability in humans |
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