Tryptophan metabolism in children with attentional deficit disorder
The authors present the first report, to their knowledge, of hyperserotonemia in children with attentional deficit disorder who had normal intelligence. Hyperserotonemic children had significantly lower levels of plasma total and protein-bound tryptophan and a higher percentage of free tryptophan th...
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| Veröffentlicht in: | The American journal of psychiatry 1981-08, Vol.138 (8), p.1082-1085 |
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| container_end_page | 1085 |
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| container_issue | 8 |
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| container_title | The American journal of psychiatry |
| container_volume | 138 |
| creator | Irwin, M Belendiuk, K McCloskey, K Freedman, D X |
| description | The authors present the first report, to their knowledge, of
hyperserotonemia in children with attentional deficit disorder who had
normal intelligence. Hyperserotonemic children had significantly lower
levels of plasma total and protein-bound tryptophan and a higher percentage
of free tryptophan than those with normal serotonin levels. Plasma
kynurenine did not differ, suggesting that the hyperserotonemia is not due
to a blockade of the kynurenine pathway but may reflect on increase in
tissue tryptophan uptake and use. |
| doi_str_mv | 10.1176/ajp.138.8.1082 |
| format | Article |
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hyperserotonemia in children with attentional deficit disorder who had
normal intelligence. Hyperserotonemic children had significantly lower
levels of plasma total and protein-bound tryptophan and a higher percentage
of free tryptophan than those with normal serotonin levels. Plasma
kynurenine did not differ, suggesting that the hyperserotonemia is not due
to a blockade of the kynurenine pathway but may reflect on increase in
tissue tryptophan uptake and use.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.138.8.1082</identifier><identifier>PMID: 7258386</identifier><language>eng</language><publisher>United States: American Psychiatric Publishing</publisher><subject>Adolescent ; Adult ; Attention - physiology ; Attention Deficit Disorder with Hyperactivity - blood ; Blood Platelets - metabolism ; Child ; Child, Preschool ; Dextroamphetamine - therapeutic use ; Humans ; Intelligence ; Kynurenine - blood ; Methylphenidate - therapeutic use ; Protein Binding ; Serotonin - blood ; Tryptophan - blood</subject><ispartof>The American journal of psychiatry, 1981-08, Vol.138 (8), p.1082-1085</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a354t-b297521d29afa3c9eb8c2f3c6384bea5a7f2b1db190a4a8160ee8d332c1e7f583</citedby><cites>FETCH-LOGICAL-a354t-b297521d29afa3c9eb8c2f3c6384bea5a7f2b1db190a4a8160ee8d332c1e7f583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.138.8.1082$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.138.8.1082$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,777,781,2846,21610,27850,27905,27906,77540,77541</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7258386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Irwin, M</creatorcontrib><creatorcontrib>Belendiuk, K</creatorcontrib><creatorcontrib>McCloskey, K</creatorcontrib><creatorcontrib>Freedman, D X</creatorcontrib><title>Tryptophan metabolism in children with attentional deficit disorder</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>The authors present the first report, to their knowledge, of
hyperserotonemia in children with attentional deficit disorder who had
normal intelligence. Hyperserotonemic children had significantly lower
levels of plasma total and protein-bound tryptophan and a higher percentage
of free tryptophan than those with normal serotonin levels. Plasma
kynurenine did not differ, suggesting that the hyperserotonemia is not due
to a blockade of the kynurenine pathway but may reflect on increase in
tissue tryptophan uptake and use.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Attention - physiology</subject><subject>Attention Deficit Disorder with Hyperactivity - blood</subject><subject>Blood Platelets - metabolism</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dextroamphetamine - therapeutic use</subject><subject>Humans</subject><subject>Intelligence</subject><subject>Kynurenine - blood</subject><subject>Methylphenidate - therapeutic use</subject><subject>Protein Binding</subject><subject>Serotonin - blood</subject><subject>Tryptophan - blood</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNptkEtLAzEUhYMoWqtbd8KA4EZmzKN5zFKKLyi4qeAuZJIMTZmZjEmK9N-b0iIiri6X-51zDweAKwQrhDi7V-uxQkRUokJQ4CMwQZTQkmMsjsEEQojLmpKPM3Ae4zqvkHB8Ck45poIINgHzZdiOyY8rNRS9TarxnYt94YZCr1xngh2KL5dWhUrJDsn5QXWFsa3TLhXGRR-MDRfgpFVdtJeHOQXvT4_L-Uu5eHt-nT8sSkXoLJUNrjnFyOBatYro2jZC45ZoRsSssYoq3uIGmQbVUM2UQAxaKwwhWCPL25x3Cm73vmPwnxsbk-xd1Lbr1GD9JkpOKEOMoQze_AHXfhNy9CgRQZBBAmmdqWpP6eBjDLaVY3C9CluJoNx1K3O3WSCkkLtus-D6YLtpemt-8EOZ-X63v6txdL9e_u_2DRSFgv4</recordid><startdate>198108</startdate><enddate>198108</enddate><creator>Irwin, M</creator><creator>Belendiuk, K</creator><creator>McCloskey, K</creator><creator>Freedman, D X</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HAWNG</scope><scope>HBMBR</scope><scope>IBDFT</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>7X8</scope></search><sort><creationdate>198108</creationdate><title>Tryptophan metabolism in children with attentional deficit disorder</title><author>Irwin, M ; Belendiuk, K ; McCloskey, K ; Freedman, D X</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a354t-b297521d29afa3c9eb8c2f3c6384bea5a7f2b1db190a4a8160ee8d332c1e7f583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Attention - physiology</topic><topic>Attention Deficit Disorder with Hyperactivity - blood</topic><topic>Blood Platelets - metabolism</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dextroamphetamine - therapeutic use</topic><topic>Humans</topic><topic>Intelligence</topic><topic>Kynurenine - blood</topic><topic>Methylphenidate - therapeutic use</topic><topic>Protein Binding</topic><topic>Serotonin - blood</topic><topic>Tryptophan - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Irwin, M</creatorcontrib><creatorcontrib>Belendiuk, K</creatorcontrib><creatorcontrib>McCloskey, K</creatorcontrib><creatorcontrib>Freedman, D X</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Periodicals Index Online Segment 13</collection><collection>Periodicals Index Online Segment 14</collection><collection>Periodicals Index Online Segment 27</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - 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hyperserotonemia in children with attentional deficit disorder who had
normal intelligence. Hyperserotonemic children had significantly lower
levels of plasma total and protein-bound tryptophan and a higher percentage
of free tryptophan than those with normal serotonin levels. Plasma
kynurenine did not differ, suggesting that the hyperserotonemia is not due
to a blockade of the kynurenine pathway but may reflect on increase in
tissue tryptophan uptake and use.</abstract><cop>United States</cop><pub>American Psychiatric Publishing</pub><pmid>7258386</pmid><doi>10.1176/ajp.138.8.1082</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 1981-08, Vol.138 (8), p.1082-1085 |
| issn | 0002-953X 1535-7228 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73561661 |
| source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
| subjects | Adolescent Adult Attention - physiology Attention Deficit Disorder with Hyperactivity - blood Blood Platelets - metabolism Child Child, Preschool Dextroamphetamine - therapeutic use Humans Intelligence Kynurenine - blood Methylphenidate - therapeutic use Protein Binding Serotonin - blood Tryptophan - blood |
| title | Tryptophan metabolism in children with attentional deficit disorder |
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