Recombinant Fowlpox Viruses Encoding the Anchor-modified gp100 Melanoma Antigen Can Generate Antitumor Immune Responses in Patients with Metastatic Melanoma

Purpose: The purpose of this study was to evaluate the immunological responses and therapeutic effectiveness of immunization with fowlpox vaccines encoding the gp100 melanoma antigen in patients with metastatic melanoma. Experimental Design: In three consecutive clinical trials, patients were immuni...

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Veröffentlicht in:	Clinical cancer research 2003-08, Vol.9 (8), p.2973-2980
Hauptverfasser:	Rosenberg, Steven A, Yang, James C, Schwartzentruber, Douglas J, Hwu, Patrick, Topalian, Suzanne L, Sherry, Richard M, Restifo, Nicholas P, Wunderlich, John R, Seipp, Claudia A, Rogers-Freezer, Linda, Morton, Kathleen E, Mavroukakis, Sharon A, Gritz, Linda, Panicali, Dennis L, White, Donald E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, Neoplasm - chemistry Antineoplastic agents Biological and medical sciences Cancer Vaccines CD8-Positive T-Lymphocytes - metabolism Cell Line, Tumor Epitopes - chemistry Female Fowlpox virus - chemistry gp100 Melanoma Antigen HLA-A Antigens - genetics HLA-A2 Antigen Humans Immunoglobulin G - chemistry Immunotherapy Interferon-gamma - metabolism Interleukin-2 - metabolism Male Medical sciences Melanoma - metabolism Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Middle Aged Neoplasm Proteins - chemistry Neoplasm Proteins - metabolism Peptides - chemistry Pharmacology. Drug treatments Vaccines - chemistry Vaccinia virus - metabolism
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