Inhibitory Effects of N-(3,5-Dimethoxy-4-n-octyloxycinnamoyl)-N′-(3,4-dimethylphenyl)piperazine (YIC-C8-434), an Acyl-CoA:Cholesterol O-Acyltransferase Inhibitor, on Cholesterol Esterification in the Intestine and Liver

The effects of an acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, N-(3,5-dimethoxy-4-n-octyloxycinnamoyl)-N′-(3,4-dimethylphenyl)piperazine (YIC-C8-434), on cholesterol esterification in the intestine and liver were investigated in vitro and in vivo. YIC-C8-434 inhibited the formation of ch...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2003, Vol.26(8), pp.1125-1128
Hauptverfasser:	Ohishi, Kenji, Sawada, Haruji, Yoshida, Yasuto, Yokoi, Wakae, Hatano, Hiroshi, Aiyama, Ritsuo, Watanabe, Tsunekazu, Yokokura, Teruo
Format:	Artikel
Sprache:	eng
Schlagworte:	acyl-CoA:cholesterol O-acyltransferase inhibitor Animals Caco-2 Cells cholesterol esterification Cholesterol Esters - antagonists & inhibitors Cholesterol Esters - metabolism Cinnamates - pharmacology Dose-Response Relationship, Drug hepatic cholesterol secretion Humans intestinal cholesterol absorption Intestinal Mucosa - metabolism Intestines - drug effects Intestines - enzymology Liver - drug effects Liver - enzymology Male Piperazines - pharmacology Rats Rats, Sprague-Dawley Sterol O-Acyltransferase - antagonists & inhibitors Sterol O-Acyltransferase - metabolism YIC-C8-434
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