Impaired glucose homeostasis, neutrophil trafficking and function in mice lacking the glucose-6-phosphate transporter

Glycogen storage disease type Ib (GSD-Ib) is caused by a deficiency in the glucose-6-phosphate transporter (G6PT). In addition to disrupted glucose homeostasis, GSD-Ib patients have unexplained and unexpected defects in neutrophil respiratory burst, chemotaxis and calcium flux, in response to the ba...

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Veröffentlicht in:	Human molecular genetics 2003-10, Vol.12 (19), p.2547-2558
Hauptverfasser:	Chen, Li-Yuan, Shieh, Jeng-Jer, Lin, Baochuan, Pan, Chi-Jiunn, Gao, Ji-Liang, Murphy, Philip M., Roe, Thomas F., Moses, Shimon, Ward, Jerrold M., Lee, Eric J., Westphal, Heiner, Mansfield, Brian C., Chou, Janice Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiporters - deficiency Biological and medical sciences Calcium - metabolism Chemokines - metabolism Chemotaxis, Leukocyte Classical genetics, quantitative genetics, hybrids Disease Models, Animal Fundamental and applied biological sciences. Psychology Genes, Recessive Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Glucose - metabolism Glycogen Storage Disease Type I - etiology Glycogen Storage Disease Type I - pathology Homeostasis Human Kidney - pathology Kinetics Liver - pathology Mice Mice, Knockout Molecular and cellular biology Monosaccharide Transport Proteins - deficiency Neutropenia - etiology Neutropenia - physiopathology Neutrophils - metabolism Respiratory Burst Restriction Mapping Time Factors
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