Somal size of prefrontal cortical pyramidal neurons in schizophrenia: differential effects across neuronal subpopulations

Cognitive dysfunction in schizophrenia may be related to morphologic abnormalities of pyramidal neurons in the dorsal prefrontal cortex (dPFC) and the largest pyramidal neurons in deep layer 3 may be most affected. Immunoreactivity (IR) for the nonphosphorylated epitopes of neurofilament protein (NN...

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Veröffentlicht in:	Biological psychiatry (1969) 2003-07, Vol.54 (2), p.111-120
Hauptverfasser:	Pierri, Joseph N, Volk, Christine L.E, Auh, Sungyoung, Sampson, Allan, Lewis, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Aged Autopsy Biological and medical sciences Case-Control Studies Cell Count Female Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Nervous system neurofilament protein Neurofilament Proteins - analysis Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques postmortem prefrontal cortex Prefrontal Cortex - pathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Pyramidal Cells - pathology pyramidal neurons Schizophrenia Schizophrenia - pathology somal size
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