Approaches to multisite clinical trials: the National Institute of Mental Health perspective
The Division of Services and Intervention Research of the National Institute of Mental Health (NIMH) utilizes a variety of methodologies and approaches in the development of its clinical trials program. In this article, we describe the need for large multisite trials; the mechanisms for addressing t...
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| Veröffentlicht in: | Schizophrenia bulletin 2003, Vol.29 (1), p.7-13 |
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| container_title | Schizophrenia bulletin |
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| creator | Lebowitz, Barry D Vitiello, Benedetto Norquist, Grayson S |
| description | The Division of Services and Intervention Research of the National Institute of Mental Health (NIMH) utilizes a variety of methodologies and approaches in the development of its clinical trials program. In this article, we describe the need for large multisite trials; the mechanisms for addressing this need; and the various approaches that have been used. In the course of carrying out this initiative, we have created opportunities for the Institute and its trial investigators to receive advice and input from the field. We describe the role and function of the trial coordinating center and NIMH staff. We identify the first steps to be taken in the initiation of a trial and highlight the opportunity for ancillary studies. Finally, we enumerate some of the pitfalls of large clinical trials and discuss measures taken to anticipate and address them. |
| doi_str_mv | 10.1093/oxfordjournals.schbul.a006992 |
| format | Article |
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| identifier | ISSN: 0586-7614 |
| ispartof | Schizophrenia bulletin, 2003, Vol.29 (1), p.7-13 |
| issn | 0586-7614 1745-1701 |
| language | eng |
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| source | MEDLINE; EBSCOhost APA PsycARTICLES; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Oxford Journals |
| subjects | Clinical Trials Clinical Trials as Topic - standards Empirical Methods Experimental Design Human Humans Mental Disorders - therapy Mental Health Services - organization & administration Multicenter Studies as Topic - standards National Institute of Mental Health (U.S.) Professional Organizations Public Health United States |
| title | Approaches to multisite clinical trials: the National Institute of Mental Health perspective |
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