Sialoside specificity of the siglec family assessed using novel multivalent probes: identification of potent inhibitors of myelin-associated glycoprotein

Ten of the 11 known human siglecs or their murine orthologs have been evaluated for their specificity for over 25 synthetic sialosides representing most of the major sequences terminating carbohydrate groups of glycoproteins and glycolipids. Analysis has been performed using a novel multivalent plat...

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Veröffentlicht in:	The Journal of biological chemistry 2003-08, Vol.278 (33), p.31007-31019
Hauptverfasser:	Blixt, Ola, Collins, Brian E, van den Nieuwenhof, Ingrid M, Crocker, Paul R, Paulson, James C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase Animals Antigens, CD - genetics Antigens, CD - metabolism Antigens, Differentiation, B-Lymphocyte - genetics Antigens, Differentiation, B-Lymphocyte - metabolism Antigens, Differentiation, Myelomonocytic - genetics Antigens, Differentiation, Myelomonocytic - metabolism Carbohydrate Sequence Cell Adhesion Molecules Chimera CHO Cells Cricetinae Enzyme-Linked Immunosorbent Assay Galactosides - chemical synthesis Galactosides - metabolism Glycolipids - chemical synthesis Glycolipids - metabolism Glycoproteins - chemical synthesis Glycoproteins - metabolism Humans Lectins - genetics Lectins - metabolism Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Molecular Sequence Data N-Acetylneuraminic Acid - metabolism Protein Binding Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Sialic Acid Binding Ig-like Lectin 1 Sialic Acid Binding Ig-like Lectin 2 Sialic Acid Binding Immunoglobulin-like Lectins Streptavidin
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