ANTITUMOR ACTIVITY OF 5-SUBSTITUTED 3-(1'-ANILINOETHYLIDENE) PYRROLIDINE-2, 4-DIONE
Antitumor activity of various compounds of tenuazonic acid analogs, 5-substituted 3-(1'-anilinoethylidene)pyrrolidine-2, 4-dione, was tested in vitro and in vivo. Among these compounds, 5-benzyl and 5-(p-hydroxybenzyl) derivatives were found to be highly effective against Yoshida sarcoma cells...
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| Veröffentlicht in: | GANN Japanese Journal of Cancer Research 1971/06/30, Vol.62(3), pp.199-206 |
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| container_issue | 3 |
| container_start_page | 199 |
| container_title | GANN Japanese Journal of Cancer Research |
| container_volume | 62 |
| creator | YUKI, Hidetaka KITANAKA, Eiryo YAMAO, Akira KARIYA, Kimio HASHIMOTO, Yoshiyuki |
| description | Antitumor activity of various compounds of tenuazonic acid analogs, 5-substituted 3-(1'-anilinoethylidene)pyrrolidine-2, 4-dione, was tested in vitro and in vivo. Among these compounds, 5-benzyl and 5-(p-hydroxybenzyl) derivatives were found to be highly effective against Yoshida sarcoma cells in vitro and Ehrlich ascites tumor in vivo. The latter compound was also active against Yoshida sarcoma and L-1210 in vivo. The optical activity of the active compound does not seem to concern the antitumor activity. Structure-activity relationship of these compounds was discussed. |
| doi_str_mv | 10.20772/cancersci1959.62.3_199 |
| format | Article |
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| identifier | ISSN: 0016-450X |
| ispartof | GANN Japanese Journal of Cancer Research, 1971/06/30, Vol.62(3), pp.199-206 |
| issn | 0016-450X |
| language | eng |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aniline Compounds - pharmacology Animals Anti-Bacterial Agents - pharmacology Antineoplastic Agents - pharmacology Bacillus subtilis - drug effects Carcinoma, Ehrlich Tumor Escherichia coli - drug effects In Vitro Techniques Male Mice Neoplasms, Experimental Pyrrolidinones - pharmacology Rats Sarcoma, Yoshida Staphylococcus - drug effects Stereoisomerism |
| title | ANTITUMOR ACTIVITY OF 5-SUBSTITUTED 3-(1'-ANILINOETHYLIDENE) PYRROLIDINE-2, 4-DIONE |
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