Spectrum of manifestations of Mycobacterium tuberculosis infection in primates infected with SIV
To characterize the manifestations of coinfection with M. tuberculosis and SIV infection, we studied 12 SIV-infected rhesus monkeys, six of which were infected intrabronchially with a low dose of Mycobacterium tuberculosis H37Rv. In the six coinfected animals, M. tuberculosis antigen-stimulated lung...
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| Veröffentlicht in: | AIDS research and human retroviruses 2003-07, Vol.19 (7), p.585-595 |
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| creator | SAFI, Hassan GORMUS, Bobby J DIDIER, Peter J BLANCHARD, James L LAKEY, David L MARTIN, Louis N MURPHEY-CORB, Micheal VANKAYALAPATI, Ramakrishna BARNES, Peter F |
| description | To characterize the manifestations of coinfection with M. tuberculosis and SIV infection, we studied 12 SIV-infected rhesus monkeys, six of which were infected intrabronchially with a low dose of Mycobacterium tuberculosis H37Rv. In the six coinfected animals, M. tuberculosis antigen-stimulated lung and blood cells produced high concentrations of IFN-gamma but not IL-4 8-16 weeks after infection. Of the three coinfected animals with high levels of plasma viremia, two developed disseminated tuberculosis and the other died of bacterial peritonitis. Of three coinfected animals with moderate levels of plasma viremia, two had no clinical or radiographic evidence of tuberculosis or progressive SIV infection for 6 months after infection. At neuropsy, pulmonary granulomata were observed and acid-fast organisms or M. tuberculosis were present. These clinical, immunologic and pathologic findings are consistent with those in humans with latent tuberculosis infection (LTBI), and suggest that a model of LTBI in SIV-infected primates can be developed. Such a model will permit delineation of the immunologic and microbial factors that characterize LTBI in HIV-infected persons. |
| doi_str_mv | 10.1089/088922203322230950 |
| format | Article |
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In the six coinfected animals, M. tuberculosis antigen-stimulated lung and blood cells produced high concentrations of IFN-gamma but not IL-4 8-16 weeks after infection. Of the three coinfected animals with high levels of plasma viremia, two developed disseminated tuberculosis and the other died of bacterial peritonitis. Of three coinfected animals with moderate levels of plasma viremia, two had no clinical or radiographic evidence of tuberculosis or progressive SIV infection for 6 months after infection. At neuropsy, pulmonary granulomata were observed and acid-fast organisms or M. tuberculosis were present. These clinical, immunologic and pathologic findings are consistent with those in humans with latent tuberculosis infection (LTBI), and suggest that a model of LTBI in SIV-infected primates can be developed. Such a model will permit delineation of the immunologic and microbial factors that characterize LTBI in HIV-infected persons.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/088922203322230950</identifier><identifier>PMID: 12908936</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>AIDS/HIV ; Animals ; Biological and medical sciences ; Bronchoalveolar Lavage Fluid - chemistry ; Disease Models, Animal ; Experimental viral diseases and models ; Feasibility Studies ; Female ; Gene Expression Regulation ; Infectious diseases ; Interferon-gamma - biosynthesis ; Interferon-gamma - genetics ; Interleukin-4 - biosynthesis ; Interleukin-4 - genetics ; Leukocytes, Mononuclear - metabolism ; Lung - pathology ; Macaca mulatta ; Medical sciences ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; Simian Acquired Immunodeficiency Syndrome - complications ; Tuberculoma - pathology ; Tuberculosis, Miliary - complications ; Tuberculosis, Miliary - immunology ; Tuberculosis, Miliary - pathology ; Tuberculosis, Pulmonary - complications ; Tuberculosis, Pulmonary - immunology ; Tuberculosis, Pulmonary - pathology ; Tumor Necrosis Factor-alpha - biosynthesis ; Tumor Necrosis Factor-alpha - genetics ; Viral diseases ; Viral Load ; Viremia - complications ; Weight Loss</subject><ispartof>AIDS research and human retroviruses, 2003-07, Vol.19 (7), p.585-595</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-2ffedd7deb8f088e10908b1d51e100b44ba845fea76b3aa714e1c200e6723ed93</citedby><cites>FETCH-LOGICAL-c360t-2ffedd7deb8f088e10908b1d51e100b44ba845fea76b3aa714e1c200e6723ed93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3029,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15008163$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12908936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SAFI, Hassan</creatorcontrib><creatorcontrib>GORMUS, Bobby J</creatorcontrib><creatorcontrib>DIDIER, Peter J</creatorcontrib><creatorcontrib>BLANCHARD, James L</creatorcontrib><creatorcontrib>LAKEY, David L</creatorcontrib><creatorcontrib>MARTIN, Louis N</creatorcontrib><creatorcontrib>MURPHEY-CORB, Micheal</creatorcontrib><creatorcontrib>VANKAYALAPATI, Ramakrishna</creatorcontrib><creatorcontrib>BARNES, Peter F</creatorcontrib><title>Spectrum of manifestations of Mycobacterium tuberculosis infection in primates infected with SIV</title><title>AIDS research and human retroviruses</title><addtitle>AIDS Res Hum Retroviruses</addtitle><description>To characterize the manifestations of coinfection with M. tuberculosis and SIV infection, we studied 12 SIV-infected rhesus monkeys, six of which were infected intrabronchially with a low dose of Mycobacterium tuberculosis H37Rv. 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GORMUS, Bobby J ; DIDIER, Peter J ; BLANCHARD, James L ; LAKEY, David L ; MARTIN, Louis N ; MURPHEY-CORB, Micheal ; VANKAYALAPATI, Ramakrishna ; BARNES, Peter F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-2ffedd7deb8f088e10908b1d51e100b44ba845fea76b3aa714e1c200e6723ed93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bronchoalveolar Lavage Fluid - chemistry</topic><topic>Disease Models, Animal</topic><topic>Experimental viral diseases and models</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Gene Expression Regulation</topic><topic>Infectious diseases</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interferon-gamma - genetics</topic><topic>Interleukin-4 - biosynthesis</topic><topic>Interleukin-4 - genetics</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Lung - pathology</topic><topic>Macaca mulatta</topic><topic>Medical sciences</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - genetics</topic><topic>Simian Acquired Immunodeficiency Syndrome - complications</topic><topic>Tuberculoma - pathology</topic><topic>Tuberculosis, Miliary - complications</topic><topic>Tuberculosis, Miliary - immunology</topic><topic>Tuberculosis, Miliary - pathology</topic><topic>Tuberculosis, Pulmonary - complications</topic><topic>Tuberculosis, Pulmonary - immunology</topic><topic>Tuberculosis, Pulmonary - pathology</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Viral diseases</topic><topic>Viral Load</topic><topic>Viremia - complications</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SAFI, Hassan</creatorcontrib><creatorcontrib>GORMUS, Bobby J</creatorcontrib><creatorcontrib>DIDIER, Peter J</creatorcontrib><creatorcontrib>BLANCHARD, James L</creatorcontrib><creatorcontrib>LAKEY, David L</creatorcontrib><creatorcontrib>MARTIN, Louis N</creatorcontrib><creatorcontrib>MURPHEY-CORB, Micheal</creatorcontrib><creatorcontrib>VANKAYALAPATI, Ramakrishna</creatorcontrib><creatorcontrib>BARNES, Peter F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS research and human retroviruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SAFI, Hassan</au><au>GORMUS, Bobby J</au><au>DIDIER, Peter J</au><au>BLANCHARD, James L</au><au>LAKEY, David L</au><au>MARTIN, Louis N</au><au>MURPHEY-CORB, Micheal</au><au>VANKAYALAPATI, Ramakrishna</au><au>BARNES, Peter F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spectrum of manifestations of Mycobacterium tuberculosis infection in primates infected with SIV</atitle><jtitle>AIDS research and human retroviruses</jtitle><addtitle>AIDS Res Hum Retroviruses</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>19</volume><issue>7</issue><spage>585</spage><epage>595</epage><pages>585-595</pages><issn>0889-2229</issn><eissn>1931-8405</eissn><coden>ARHRE7</coden><abstract>To characterize the manifestations of coinfection with M. tuberculosis and SIV infection, we studied 12 SIV-infected rhesus monkeys, six of which were infected intrabronchially with a low dose of Mycobacterium tuberculosis H37Rv. In the six coinfected animals, M. tuberculosis antigen-stimulated lung and blood cells produced high concentrations of IFN-gamma but not IL-4 8-16 weeks after infection. Of the three coinfected animals with high levels of plasma viremia, two developed disseminated tuberculosis and the other died of bacterial peritonitis. Of three coinfected animals with moderate levels of plasma viremia, two had no clinical or radiographic evidence of tuberculosis or progressive SIV infection for 6 months after infection. At neuropsy, pulmonary granulomata were observed and acid-fast organisms or M. tuberculosis were present. These clinical, immunologic and pathologic findings are consistent with those in humans with latent tuberculosis infection (LTBI), and suggest that a model of LTBI in SIV-infected primates can be developed. 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| ispartof | AIDS research and human retroviruses, 2003-07, Vol.19 (7), p.585-595 |
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| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | AIDS/HIV Animals Biological and medical sciences Bronchoalveolar Lavage Fluid - chemistry Disease Models, Animal Experimental viral diseases and models Feasibility Studies Female Gene Expression Regulation Infectious diseases Interferon-gamma - biosynthesis Interferon-gamma - genetics Interleukin-4 - biosynthesis Interleukin-4 - genetics Leukocytes, Mononuclear - metabolism Lung - pathology Macaca mulatta Medical sciences RNA, Messenger - biosynthesis RNA, Messenger - genetics Simian Acquired Immunodeficiency Syndrome - complications Tuberculoma - pathology Tuberculosis, Miliary - complications Tuberculosis, Miliary - immunology Tuberculosis, Miliary - pathology Tuberculosis, Pulmonary - complications Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - pathology Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics Viral diseases Viral Load Viremia - complications Weight Loss |
| title | Spectrum of manifestations of Mycobacterium tuberculosis infection in primates infected with SIV |
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