Simvastatin induces apoptosis of B-CLL cells by activation of mitochondrial caspase 9

Background and Objectives. Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world. Despite several advances in therapeutic options, the disease remains incurable. Recently, it was repeatedly demonstrated that statins, competitive inhibitors of 3-hydroxy-3-methyl glutaryl...

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Veröffentlicht in:	Experimental hematology 2003-09, Vol.31 (9), p.779-783
Hauptverfasser:	Chapman-Shimshoni, Daphne, Yuklea, Mona, Radnay, Judith, Shapiro, Hava, Lishner, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Caspase 3 Caspase 8 Caspase 9 Caspases - metabolism Enzyme Activation - drug effects Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - enzymology Leukemia, Lymphocytic, Chronic, B-Cell - pathology Simvastatin - pharmacology Simvastatin - therapeutic use Tumor Cells, Cultured
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