Association between Interleukin-8 Gene Alleles and Human Susceptibility to Tuberculosis Disease
Interleukin (IL)-8 is involved in the pathogenesis of human tuberculosis (TB). However, the contribution of polymorphisms of the IL-8 gene and its receptor genes CXCR-1 and CXCR-2 to human TB susceptibility remains untested. In a case-control study, white subjects with TB disease were more likely to...
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| Veröffentlicht in: | The Journal of infectious diseases 2003-08, Vol.188 (3), p.349-355 |
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| container_title | The Journal of infectious diseases |
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| creator | Ma, Xin Reich, Robert A. Wright, John A. Tooker, Heather R. Teeter, Larry D. Musser, James M. Graviss, Edward A. |
| description | Interleukin (IL)-8 is involved in the pathogenesis of human tuberculosis (TB). However, the contribution of polymorphisms of the IL-8 gene and its receptor genes CXCR-1 and CXCR-2 to human TB susceptibility remains untested. In a case-control study, white subjects with TB disease were more likely to be homozygous for the IL-8 −251A allele, compared with control subjects (odds ratio [OR], 3.41; 95% confidence interval [CI], 1.52–7.64). African Americans with TB also showed an increased odds of being homozygous for this allele (OR, 3.46; 95% CI, 1.48–8.08). To exclude population artifacts in the case-control study, a separate analysis that used a transmission-disequilibrium test with 76 informative families confirmed that the IL-8 −251A allele was preferentially transmitted to TB-infected children (P=.02). CXCR-1 and CXCR-2 did not demonstrate significant associations with TB susceptibility. These data suggest that IL-8 is important in the genetic control of human TB susceptibility. |
| doi_str_mv | 10.1086/376559 |
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However, the contribution of polymorphisms of the IL-8 gene and its receptor genes CXCR-1 and CXCR-2 to human TB susceptibility remains untested. In a case-control study, white subjects with TB disease were more likely to be homozygous for the IL-8 −251A allele, compared with control subjects (odds ratio [OR], 3.41; 95% confidence interval [CI], 1.52–7.64). African Americans with TB also showed an increased odds of being homozygous for this allele (OR, 3.46; 95% CI, 1.48–8.08). To exclude population artifacts in the case-control study, a separate analysis that used a transmission-disequilibrium test with 76 informative families confirmed that the IL-8 −251A allele was preferentially transmitted to TB-infected children (P=.02). CXCR-1 and CXCR-2 did not demonstrate significant associations with TB susceptibility. These data suggest that IL-8 is important in the genetic control of human TB susceptibility.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/376559</identifier><identifier>PMID: 12870115</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Alleles ; Bacterial diseases ; Biological and medical sciences ; Black or African American ; Black People ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Genetic Predisposition to Disease ; Human bacterial diseases ; Humans ; Infant ; Infectious diseases ; Interleukin-8 - genetics ; Linkage Disequilibrium ; Male ; Medical sciences ; Middle Aged ; Mycobacterium tuberculosis ; Nuclear Family ; Texas - epidemiology ; Tuberculosis - epidemiology ; Tuberculosis - genetics ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Pulmonary - genetics ; White People</subject><ispartof>The Journal of infectious diseases, 2003-08, Vol.188 (3), p.349-355</ispartof><rights>Copyright 2003 Infectious Diseases Society of America</rights><rights>2003 by the Infectious Diseases Society of America 2003</rights><rights>2003 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Aug 1 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-5cd2c38f55182cb69dfcdba835f9070c47f284a54678a0c6cf2b8dd53f0559a23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30075601$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30075601$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15049100$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12870115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Xin</creatorcontrib><creatorcontrib>Reich, Robert A.</creatorcontrib><creatorcontrib>Wright, John A.</creatorcontrib><creatorcontrib>Tooker, Heather R.</creatorcontrib><creatorcontrib>Teeter, Larry D.</creatorcontrib><creatorcontrib>Musser, James M.</creatorcontrib><creatorcontrib>Graviss, Edward A.</creatorcontrib><title>Association between Interleukin-8 Gene Alleles and Human Susceptibility to Tuberculosis Disease</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Interleukin (IL)-8 is involved in the pathogenesis of human tuberculosis (TB). However, the contribution of polymorphisms of the IL-8 gene and its receptor genes CXCR-1 and CXCR-2 to human TB susceptibility remains untested. In a case-control study, white subjects with TB disease were more likely to be homozygous for the IL-8 −251A allele, compared with control subjects (odds ratio [OR], 3.41; 95% confidence interval [CI], 1.52–7.64). African Americans with TB also showed an increased odds of being homozygous for this allele (OR, 3.46; 95% CI, 1.48–8.08). To exclude population artifacts in the case-control study, a separate analysis that used a transmission-disequilibrium test with 76 informative families confirmed that the IL-8 −251A allele was preferentially transmitted to TB-infected children (P=.02). CXCR-1 and CXCR-2 did not demonstrate significant associations with TB susceptibility. These data suggest that IL-8 is important in the genetic control of human TB susceptibility.</description><subject>Adolescent</subject><subject>Alleles</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Black or African American</subject><subject>Black People</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Interleukin-8 - genetics</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mycobacterium tuberculosis</subject><subject>Nuclear Family</subject><subject>Texas - epidemiology</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis - genetics</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Pulmonary - genetics</subject><subject>White People</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10F1rFDEUBuAgit1W_QdKLOjd6Eky-ZjLpepuy4IXVinehEwmA9nOJms-0P57R3ZpRfAqF-fhPScvQi8IvCOgxHsmBefdI7QgnMlGCMIeowUApQ1RXXeCTnPeAkDLhHyKTghVEgjhC6SXOUfrTfEx4N6Vn84FfBmKS5Ortz40Cq9ccHg5TW5yGZsw4HXdmYC_1GzdvvjeT77c4RLxde1dsnWK2Wf8wWdnsnuGnoxmyu758T1DXz99vL5YN5vPq8uL5aaxLVGl4XaglqmRc6Ko7UU3jHbojWJ87ECCbeVIVWt4K6QyYIUdaa-GgbMR5m8bys7Q20PuPsUf1eWid36-b5pMcLFmLdkc3fFuhuf_wG2sKcy3aUpZBx2Iv9JsijknN-p98juT7jQB_advfeh7hq-OabXfueGBHQuewZsjMNmaaUwmWJ8fHIe2IwCze31wse7_v-zlwWxzieleMQDJBZB53hzmPhf3635u0q0Wkkmu1zff9Y1Uq6vV1Te9Yb8BkJKpag</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Ma, Xin</creator><creator>Reich, Robert A.</creator><creator>Wright, John A.</creator><creator>Tooker, Heather R.</creator><creator>Teeter, Larry D.</creator><creator>Musser, James M.</creator><creator>Graviss, Edward A.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>Association between Interleukin-8 Gene Alleles and Human Susceptibility to Tuberculosis Disease</title><author>Ma, Xin ; Reich, Robert A. ; Wright, John A. ; Tooker, Heather R. ; Teeter, Larry D. ; Musser, James M. ; Graviss, Edward A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-5cd2c38f55182cb69dfcdba835f9070c47f284a54678a0c6cf2b8dd53f0559a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Alleles</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Black or African American</topic><topic>Black People</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Interleukin-8 - genetics</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mycobacterium tuberculosis</topic><topic>Nuclear Family</topic><topic>Texas - epidemiology</topic><topic>Tuberculosis - epidemiology</topic><topic>Tuberculosis - genetics</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Tuberculosis, Pulmonary - genetics</topic><topic>White People</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Xin</creatorcontrib><creatorcontrib>Reich, Robert A.</creatorcontrib><creatorcontrib>Wright, John A.</creatorcontrib><creatorcontrib>Tooker, Heather R.</creatorcontrib><creatorcontrib>Teeter, Larry D.</creatorcontrib><creatorcontrib>Musser, James M.</creatorcontrib><creatorcontrib>Graviss, Edward A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Xin</au><au>Reich, Robert A.</au><au>Wright, John A.</au><au>Tooker, Heather R.</au><au>Teeter, Larry D.</au><au>Musser, James M.</au><au>Graviss, Edward A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Interleukin-8 Gene Alleles and Human Susceptibility to Tuberculosis Disease</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>188</volume><issue>3</issue><spage>349</spage><epage>355</epage><pages>349-355</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Interleukin (IL)-8 is involved in the pathogenesis of human tuberculosis (TB). However, the contribution of polymorphisms of the IL-8 gene and its receptor genes CXCR-1 and CXCR-2 to human TB susceptibility remains untested. In a case-control study, white subjects with TB disease were more likely to be homozygous for the IL-8 −251A allele, compared with control subjects (odds ratio [OR], 3.41; 95% confidence interval [CI], 1.52–7.64). African Americans with TB also showed an increased odds of being homozygous for this allele (OR, 3.46; 95% CI, 1.48–8.08). To exclude population artifacts in the case-control study, a separate analysis that used a transmission-disequilibrium test with 76 informative families confirmed that the IL-8 −251A allele was preferentially transmitted to TB-infected children (P=.02). CXCR-1 and CXCR-2 did not demonstrate significant associations with TB susceptibility. These data suggest that IL-8 is important in the genetic control of human TB susceptibility.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>12870115</pmid><doi>10.1086/376559</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Alleles Bacterial diseases Biological and medical sciences Black or African American Black People Case-Control Studies Child Child, Preschool Female Genetic Predisposition to Disease Human bacterial diseases Humans Infant Infectious diseases Interleukin-8 - genetics Linkage Disequilibrium Male Medical sciences Middle Aged Mycobacterium tuberculosis Nuclear Family Texas - epidemiology Tuberculosis - epidemiology Tuberculosis - genetics Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - genetics White People |
| title | Association between Interleukin-8 Gene Alleles and Human Susceptibility to Tuberculosis Disease |
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