Lack of tolerance and rapid recovery of cimetidine-inhibited chlordiazepoxide (librium) elimination

Cimetidine has been shown to inhibit oxidative metabolism of several drugs while sparing the glucuronidation pathways of drug metabolism. We studied the time-course of inhibition and recovery of cimetidine-inhibited chlordiazepoxide elimination in 7 healthy subjects. Chlordiazepoxide elimination was...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1981-09, Vol.81 (3), p.547-551
Hauptverfasser:	Patwardhan, Rashmi V., Johnson, Raymond F., Sinclair, Alicia P., Schenker, Steven, Speeg, K.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Chlordiazepoxide - analogs & derivatives Chlordiazepoxide - blood Chlordiazepoxide - metabolism Cimetidine - pharmacology Female Guanidines - pharmacology Humans Kinetics Male
Online-Zugang:	Volltext
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