Functionalized Glycomers as Growth Inhibitors and Inducers of Apoptosis in Human Glioblastoma Cells

The effects of functionalized aryl β-d-glycopyranosides (glycomers) on the proliferation, survival, and apoptosis of human glioblastoma cells in culture were evaluated as a way to control tumor progression. The results showed that inhibition of growth and/or induction of apoptosis can be achieved by...

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Veröffentlicht in:	Journal of medicinal chemistry 2003-08, Vol.46 (17), p.3600-3611
Hauptverfasser:	Hanessian, Stephen, Zhan, Lijie, Bovey, Raymonde, Saavedra, Oscar M, Juillerat-Jeanneret, Lucienne
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis Biological and medical sciences Brain Neoplasms - pathology Cell Division - drug effects Cell Line Cerebral Cortex - cytology Endothelium - cytology Endothelium - drug effects Fibroblasts - cytology Fibroblasts - drug effects General aspects Glioblastoma - pathology Glucosides - chemical synthesis Glucosides - chemistry Glucosides - pharmacology Humans Medical sciences Pharmacology. Drug treatments Tumor Cells, Cultured
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