A Cohort Study of Health Effects of Human T-Cell Lymphotropic Virus Type I Infection in Jamaican Children
Human T-cell lymphotropic virus type I (HTLV-I) infection in childhood is believed to play an important role in risk for adult T-cell leukemia/lymphoma. Although HTLV-I is known to be associated with infective dermatitis in childhood, other HTLV-I-associated morbidity in children has not been well s...
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| Veröffentlicht in: | Pediatrics (Evanston) 2003-08, Vol.112 (2), p.e136-e142 |
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| container_title | Pediatrics (Evanston) |
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| creator | Maloney, Elizabeth M Wiktor, Stefan Z Palmer, Paulette Cranston, Beverley Pate, Ernest J Cohn, Sylvia Kim, Norma Miley, Wendell Thomas, Terry L Blattner, William A Hanchard, Barrie |
| description | Human T-cell lymphotropic virus type I (HTLV-I) infection in childhood is believed to play an important role in risk for adult T-cell leukemia/lymphoma. Although HTLV-I is known to be associated with infective dermatitis in childhood, other HTLV-I-associated morbidity in children has not been well studied. We sought to determine the HTLV-I-associated health effects in Jamaican children.
We compared incidence rates of several health outcomes in 28 HTLV-I-infected and 280 uninfected children clinically followed from age 6 weeks to a maximum of 10 years. Cox proportional hazards regression analysis was used to analyze these prospectively collected data, adjusting for confounding effects of other variables as necessary.
HTLV-I-infected children had significantly higher incidence rates of seborrheic dermatitis (rate ratio [RR] = 4.8, 95% confidence interval [CI] = 1.9-12.5), eczema (RR = 3.1, CI = 1.2-7.9) and persistent hyperreflexia (RR = 3.7, CI = 1.6-8.2). Additionally, HTLV-I infected children had increased rates of severe anemia (RR = 2.5, CI = 0.8-7.9) and abnormal lymphocytes (RR = 2.4, CI = 0.8-7.6) that were of borderline statistical significance.
Our study suggests that HTLV-I-associated skin diseases of childhood may include seborrheic dermatitis and eczema. Additionally, these data suggest that persistent hyperreflexia of the lower limbs may be an early sign of HTLV-I-associated neurologic involvement in children. Expansion and continued clinical observation of this cohort would be valuable. |
| doi_str_mv | 10.1542/peds.112.2.e136 |
| format | Article |
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We compared incidence rates of several health outcomes in 28 HTLV-I-infected and 280 uninfected children clinically followed from age 6 weeks to a maximum of 10 years. Cox proportional hazards regression analysis was used to analyze these prospectively collected data, adjusting for confounding effects of other variables as necessary.
HTLV-I-infected children had significantly higher incidence rates of seborrheic dermatitis (rate ratio [RR] = 4.8, 95% confidence interval [CI] = 1.9-12.5), eczema (RR = 3.1, CI = 1.2-7.9) and persistent hyperreflexia (RR = 3.7, CI = 1.6-8.2). Additionally, HTLV-I infected children had increased rates of severe anemia (RR = 2.5, CI = 0.8-7.9) and abnormal lymphocytes (RR = 2.4, CI = 0.8-7.6) that were of borderline statistical significance.
Our study suggests that HTLV-I-associated skin diseases of childhood may include seborrheic dermatitis and eczema. Additionally, these data suggest that persistent hyperreflexia of the lower limbs may be an early sign of HTLV-I-associated neurologic involvement in children. Expansion and continued clinical observation of this cohort would be valuable.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.112.2.e136</identifier><identifier>PMID: 12897319</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>United States: Am Acad Pediatrics</publisher><subject>Anemia - epidemiology ; Anemia - etiology ; Breast Feeding ; Cohort Studies ; Dermatitis, Seborrheic - epidemiology ; Dermatitis, Seborrheic - etiology ; Eczema - epidemiology ; Eczema - etiology ; HTLV-I Infections - complications ; HTLV-I Infections - physiopathology ; Incidence ; Jamaica - epidemiology ; Neurologic Examination ; Pediatrics ; Proportional Hazards Models ; Reflex, Abnormal</subject><ispartof>Pediatrics (Evanston), 2003-08, Vol.112 (2), p.e136-e142</ispartof><rights>Copyright National Library of Medicine - MEDLINE Abstracts Aug 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-f59b1819638cf3b5dd064cd792c5af6e5ea1b2f38a2fa1f4ed97d88fd84b70673</citedby><cites>FETCH-LOGICAL-c401t-f59b1819638cf3b5dd064cd792c5af6e5ea1b2f38a2fa1f4ed97d88fd84b70673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12897319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maloney, Elizabeth M</creatorcontrib><creatorcontrib>Wiktor, Stefan Z</creatorcontrib><creatorcontrib>Palmer, Paulette</creatorcontrib><creatorcontrib>Cranston, Beverley</creatorcontrib><creatorcontrib>Pate, Ernest J</creatorcontrib><creatorcontrib>Cohn, Sylvia</creatorcontrib><creatorcontrib>Kim, Norma</creatorcontrib><creatorcontrib>Miley, Wendell</creatorcontrib><creatorcontrib>Thomas, Terry L</creatorcontrib><creatorcontrib>Blattner, William A</creatorcontrib><creatorcontrib>Hanchard, Barrie</creatorcontrib><title>A Cohort Study of Health Effects of Human T-Cell Lymphotropic Virus Type I Infection in Jamaican Children</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Human T-cell lymphotropic virus type I (HTLV-I) infection in childhood is believed to play an important role in risk for adult T-cell leukemia/lymphoma. Although HTLV-I is known to be associated with infective dermatitis in childhood, other HTLV-I-associated morbidity in children has not been well studied. We sought to determine the HTLV-I-associated health effects in Jamaican children.
We compared incidence rates of several health outcomes in 28 HTLV-I-infected and 280 uninfected children clinically followed from age 6 weeks to a maximum of 10 years. Cox proportional hazards regression analysis was used to analyze these prospectively collected data, adjusting for confounding effects of other variables as necessary.
HTLV-I-infected children had significantly higher incidence rates of seborrheic dermatitis (rate ratio [RR] = 4.8, 95% confidence interval [CI] = 1.9-12.5), eczema (RR = 3.1, CI = 1.2-7.9) and persistent hyperreflexia (RR = 3.7, CI = 1.6-8.2). Additionally, HTLV-I infected children had increased rates of severe anemia (RR = 2.5, CI = 0.8-7.9) and abnormal lymphocytes (RR = 2.4, CI = 0.8-7.6) that were of borderline statistical significance.
Our study suggests that HTLV-I-associated skin diseases of childhood may include seborrheic dermatitis and eczema. Additionally, these data suggest that persistent hyperreflexia of the lower limbs may be an early sign of HTLV-I-associated neurologic involvement in children. Expansion and continued clinical observation of this cohort would be valuable.</description><subject>Anemia - epidemiology</subject><subject>Anemia - etiology</subject><subject>Breast Feeding</subject><subject>Cohort Studies</subject><subject>Dermatitis, Seborrheic - epidemiology</subject><subject>Dermatitis, Seborrheic - etiology</subject><subject>Eczema - epidemiology</subject><subject>Eczema - etiology</subject><subject>HTLV-I Infections - complications</subject><subject>HTLV-I Infections - physiopathology</subject><subject>Incidence</subject><subject>Jamaica - epidemiology</subject><subject>Neurologic Examination</subject><subject>Pediatrics</subject><subject>Proportional Hazards Models</subject><subject>Reflex, Abnormal</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1r3DAQxUVoSDbbnnsroofevNGnLR2DSZstCz1k26uQ9VEr2JYr2ZT972snCwllDjMM7_0Y5gHwEaMd5ozcjs7mHcZkR3YO0_ICbDCSomCk4u_ABiGKC4YQvwY3OT8hhBivyBW4xkTIimK5AeEO1rGNaYKP02xPMHr44HQ3tfDee2em_LyZez3AY1G7roOHUz-2cUpxDAb-CmnO8HgaHdzD_bA6QhxgGOB33etgFlvdhs4mN7wHl1532X049y34-fX-WD8Uhx_f9vXdoTAM4anwXDZYYFlSYTxtuLWoZMZWkhiufem407ghngpNvMaeOSsrK4S3gjUVKiu6BV9euGOKf2aXJ9WHbJbL9eDinFVFOaNyqS34_J_wKc5pWG5ThAhKqBRiEd2-iEyKOSfn1ZhCr9NJYaTWCNQagVoiUEStESyOT2fs3PTOvurPP39FtuF3-zcktyKCnlIw-c34BvkPnwiTEA</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Maloney, Elizabeth M</creator><creator>Wiktor, Stefan Z</creator><creator>Palmer, Paulette</creator><creator>Cranston, Beverley</creator><creator>Pate, Ernest J</creator><creator>Cohn, Sylvia</creator><creator>Kim, Norma</creator><creator>Miley, Wendell</creator><creator>Thomas, Terry L</creator><creator>Blattner, William A</creator><creator>Hanchard, Barrie</creator><general>Am Acad Pediatrics</general><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>A Cohort Study of Health Effects of Human T-Cell Lymphotropic Virus Type I Infection in Jamaican Children</title><author>Maloney, Elizabeth M ; Wiktor, Stefan Z ; Palmer, Paulette ; Cranston, Beverley ; Pate, Ernest J ; Cohn, Sylvia ; Kim, Norma ; Miley, Wendell ; Thomas, Terry L ; Blattner, William A ; Hanchard, Barrie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-f59b1819638cf3b5dd064cd792c5af6e5ea1b2f38a2fa1f4ed97d88fd84b70673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Anemia - epidemiology</topic><topic>Anemia - etiology</topic><topic>Breast Feeding</topic><topic>Cohort Studies</topic><topic>Dermatitis, Seborrheic - epidemiology</topic><topic>Dermatitis, Seborrheic - etiology</topic><topic>Eczema - epidemiology</topic><topic>Eczema - etiology</topic><topic>HTLV-I Infections - complications</topic><topic>HTLV-I Infections - physiopathology</topic><topic>Incidence</topic><topic>Jamaica - epidemiology</topic><topic>Neurologic Examination</topic><topic>Pediatrics</topic><topic>Proportional Hazards Models</topic><topic>Reflex, Abnormal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maloney, Elizabeth M</creatorcontrib><creatorcontrib>Wiktor, Stefan Z</creatorcontrib><creatorcontrib>Palmer, Paulette</creatorcontrib><creatorcontrib>Cranston, Beverley</creatorcontrib><creatorcontrib>Pate, Ernest J</creatorcontrib><creatorcontrib>Cohn, Sylvia</creatorcontrib><creatorcontrib>Kim, Norma</creatorcontrib><creatorcontrib>Miley, Wendell</creatorcontrib><creatorcontrib>Thomas, Terry L</creatorcontrib><creatorcontrib>Blattner, William A</creatorcontrib><creatorcontrib>Hanchard, Barrie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maloney, Elizabeth M</au><au>Wiktor, Stefan Z</au><au>Palmer, Paulette</au><au>Cranston, Beverley</au><au>Pate, Ernest J</au><au>Cohn, Sylvia</au><au>Kim, Norma</au><au>Miley, Wendell</au><au>Thomas, Terry L</au><au>Blattner, William A</au><au>Hanchard, Barrie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Cohort Study of Health Effects of Human T-Cell Lymphotropic Virus Type I Infection in Jamaican Children</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>112</volume><issue>2</issue><spage>e136</spage><epage>e142</epage><pages>e136-e142</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>Human T-cell lymphotropic virus type I (HTLV-I) infection in childhood is believed to play an important role in risk for adult T-cell leukemia/lymphoma. Although HTLV-I is known to be associated with infective dermatitis in childhood, other HTLV-I-associated morbidity in children has not been well studied. We sought to determine the HTLV-I-associated health effects in Jamaican children.
We compared incidence rates of several health outcomes in 28 HTLV-I-infected and 280 uninfected children clinically followed from age 6 weeks to a maximum of 10 years. Cox proportional hazards regression analysis was used to analyze these prospectively collected data, adjusting for confounding effects of other variables as necessary.
HTLV-I-infected children had significantly higher incidence rates of seborrheic dermatitis (rate ratio [RR] = 4.8, 95% confidence interval [CI] = 1.9-12.5), eczema (RR = 3.1, CI = 1.2-7.9) and persistent hyperreflexia (RR = 3.7, CI = 1.6-8.2). Additionally, HTLV-I infected children had increased rates of severe anemia (RR = 2.5, CI = 0.8-7.9) and abnormal lymphocytes (RR = 2.4, CI = 0.8-7.6) that were of borderline statistical significance.
Our study suggests that HTLV-I-associated skin diseases of childhood may include seborrheic dermatitis and eczema. Additionally, these data suggest that persistent hyperreflexia of the lower limbs may be an early sign of HTLV-I-associated neurologic involvement in children. Expansion and continued clinical observation of this cohort would be valuable.</abstract><cop>United States</cop><pub>Am Acad Pediatrics</pub><pmid>12897319</pmid><doi>10.1542/peds.112.2.e136</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0031-4005 |
| ispartof | Pediatrics (Evanston), 2003-08, Vol.112 (2), p.e136-e142 |
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| language | eng |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ） |
| subjects | Anemia - epidemiology Anemia - etiology Breast Feeding Cohort Studies Dermatitis, Seborrheic - epidemiology Dermatitis, Seborrheic - etiology Eczema - epidemiology Eczema - etiology HTLV-I Infections - complications HTLV-I Infections - physiopathology Incidence Jamaica - epidemiology Neurologic Examination Pediatrics Proportional Hazards Models Reflex, Abnormal |
| title | A Cohort Study of Health Effects of Human T-Cell Lymphotropic Virus Type I Infection in Jamaican Children |
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