Conformationally rigid N-acyl-5-alkyl- l-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors

In the N-acyl- l-prolyl-pyrrolidine type of prolyl oligopeptidase inhibitors the l-prolyl group was replaced by different 5-alkyl- l-prolyl groups, resulting in a series of N-acyl-5-alkyl- l-prolyl-pyrrolidines. Since N-amides of 5-alkyl- l-prolines are conformationally more rigid than those of l-pr...

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