Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure

We created parabiotic mice, joining ROSA26 and PeP3banimals, to study the trafficking of hematopoietic stem cells (HSCs) from marrow to blood and their return to marrow. The transfer of HSCs was assayed by secondary marrow transplantation and was 1.0% to 2.5% after 3, 6, 8, and 12 weeks. Thus, HSC h...

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Veröffentlicht in:	Blood 2003-08, Vol.102 (4), p.1249-1253
Hauptverfasser:	Abkowitz, Janis L., Robinson, Abigail E., Kale, Sujata, Long, Michael W., Chen, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Bone Marrow - metabolism Bone Marrow Transplantation - methods Bone marrow, stem cells transplantation. Graft versus host reaction Cell differentiation, maturation, development, hematopoiesis Cell Movement - drug effects Cell Movement - physiology Cell physiology Cells, Cultured Cytokines - pharmacology Female Fundamental and applied biological sciences. Psychology Granulocyte Colony-Stimulating Factor - pharmacology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Homeostasis - drug effects Homeostasis - physiology Humans Male Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Molecular and cellular biology Parabiosis Phenotype Recombinant Proteins Spleen - cytology Spleen - metabolism Stem Cell Factor - pharmacology Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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