The preejection period of the fetal cardiac cycle. II. Maternal common internal iliac artery occlusions

The preejection period (PEP) of the fetal cardiac cycle was studied in the chronically instrumented fetal lamb. An inflatable cuff occluder was positioned around the maternal common internal iliac artery, the pregnant ewe's main uterine blood-supplying vessel. Occlusion of the maternal common i...

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Veröffentlicht in:European journal of obstetrics & gynecology and reproductive biology 1981-05, Vol.11 (6), p.419-433
Hauptverfasser: Evers, J.L.H., De Haan, J., Jongsma, H.W., Crevels, A.J., Arts, T.H.M., Martin, C.B.
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container_end_page 433
container_issue 6
container_start_page 419
container_title European journal of obstetrics & gynecology and reproductive biology
container_volume 11
creator Evers, J.L.H.
De Haan, J.
Jongsma, H.W.
Crevels, A.J.
Arts, T.H.M.
Martin, C.B.
description The preejection period (PEP) of the fetal cardiac cycle was studied in the chronically instrumented fetal lamb. An inflatable cuff occluder was positioned around the maternal common internal iliac artery, the pregnant ewe's main uterine blood-supplying vessel. Occlusion of the maternal common internal iliac artery produced a fall in p O 2 and pH and a rise in p CO 2. Fetal arterial blood pressure increased and PEP shortened, especially in the longer lasting occlusions. Fetal heart rate exhibited a bradycardia also during this type of occlusion. The fetal lamb's cardiovascular adjustments to biochemical changes caused by occlusion of the maternal uterine blood supply appear to be determined during the initial phase of occlusion by a chemoreceptor reflex-induced peripheral vasoconstriction mediated by the adrenergic nervous system. This condition is comparable to the one observed during the second part of the umbilical cord occlusions. The interaction between a supersensitive fetal myocardium and the adrenal release of catecholamines may play a dominant role during the second part of occlusion in the longer lasting experiments. Increase in peripheral resistance in the course of redistribution of blood flow during hypoxemia induces a prolongation of the PEP in the early phase of occlusion; overriding of this effect by an increase in myocardial contractility due to rising levels of adrenal catecholamines abbreviates the PEP in the later part of the longer lasting occlusions.
doi_str_mv 10.1016/0028-2243(81)90091-5
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The fetal lamb's cardiovascular adjustments to biochemical changes caused by occlusion of the maternal uterine blood supply appear to be determined during the initial phase of occlusion by a chemoreceptor reflex-induced peripheral vasoconstriction mediated by the adrenergic nervous system. This condition is comparable to the one observed during the second part of the umbilical cord occlusions. The interaction between a supersensitive fetal myocardium and the adrenal release of catecholamines may play a dominant role during the second part of occlusion in the longer lasting experiments. 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Increase in peripheral resistance in the course of redistribution of blood flow during hypoxemia induces a prolongation of the PEP in the early phase of occlusion; overriding of this effect by an increase in myocardial contractility due to rising levels of adrenal catecholamines abbreviates the PEP in the later part of the longer lasting occlusions.</description><subject>Animals</subject><subject>Arterial Occlusive Diseases - physiopathology</subject><subject>Blood Pressure</subject><subject>cardiac function</subject><subject>chronic sheep experiments</subject><subject>Female</subject><subject>fetal distress</subject><subject>Fetal Heart - physiopathology</subject><subject>fetal heart rate patterns</subject><subject>Heart Rate</subject><subject>Hypoxia - physiopathology</subject><subject>Iliac Artery</subject><subject>late decelerations</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Cardiovascular - physiopathology</subject><subject>Receptors, Adrenergic, alpha - physiology</subject><subject>Receptors, Adrenergic, beta - physiology</subject><subject>Sheep</subject><subject>systolic time intervals</subject><subject>Time Factors</subject><subject>Uterus - blood supply</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LJDEQhoMoOqv-AxdyEvfQYyofne7LwiLuOqB40XOI6Yob6e6MSY8w_37TzrBH61IU70fIQ8gFsCUwqK8Z403FuRRXDfxoGWuhUgdkAY3mla6VPCQLJhhUHECdkG85v7EyQrTH5LjmtRKMLcjr01-k64T4hm4KcaRrTCF2NHo6FcXjZHvqbOqCddRtXY9Lulot6YOdMI2zFoehxMK4v0M_O20q55ZG5_pNLrX5jBx522c83-9T8vz79unmrrp__LO6-XVfOa75VHmhhecolQYvsBGuUwBWixeGXkjhoEYNjisBkgnd1t76rml0hxK0rGsQp-Ry17tO8X2DeTJDyA773o4YN9looSSTTVuMcmd0Keac0Jt1CoNNWwPMzHzNzNfMfE0D5pOvUSX2fd-_eRmw-x_aAy36z52O5ZMfAZPJLuDosAupEDZdDF8_8A-n3YkP</recordid><startdate>198105</startdate><enddate>198105</enddate><creator>Evers, J.L.H.</creator><creator>De Haan, J.</creator><creator>Jongsma, H.W.</creator><creator>Crevels, A.J.</creator><creator>Arts, T.H.M.</creator><creator>Martin, C.B.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198105</creationdate><title>The preejection period of the fetal cardiac cycle. 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Maternal common internal iliac artery occlusions</title><author>Evers, J.L.H. ; De Haan, J. ; Jongsma, H.W. ; Crevels, A.J. ; Arts, T.H.M. ; Martin, C.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-f373f2e4571f3e83cd511a73b0ef343c16e71c2531403796fafd887de41746613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Arterial Occlusive Diseases - physiopathology</topic><topic>Blood Pressure</topic><topic>cardiac function</topic><topic>chronic sheep experiments</topic><topic>Female</topic><topic>fetal distress</topic><topic>Fetal Heart - physiopathology</topic><topic>fetal heart rate patterns</topic><topic>Heart Rate</topic><topic>Hypoxia - physiopathology</topic><topic>Iliac Artery</topic><topic>late decelerations</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Cardiovascular - physiopathology</topic><topic>Receptors, Adrenergic, alpha - physiology</topic><topic>Receptors, Adrenergic, beta - physiology</topic><topic>Sheep</topic><topic>systolic time intervals</topic><topic>Time Factors</topic><topic>Uterus - blood supply</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Evers, J.L.H.</creatorcontrib><creatorcontrib>De Haan, J.</creatorcontrib><creatorcontrib>Jongsma, H.W.</creatorcontrib><creatorcontrib>Crevels, A.J.</creatorcontrib><creatorcontrib>Arts, T.H.M.</creatorcontrib><creatorcontrib>Martin, C.B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics &amp; gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Evers, J.L.H.</au><au>De Haan, J.</au><au>Jongsma, H.W.</au><au>Crevels, A.J.</au><au>Arts, T.H.M.</au><au>Martin, C.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The preejection period of the fetal cardiac cycle. II. Maternal common internal iliac artery occlusions</atitle><jtitle>European journal of obstetrics &amp; gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>1981-05</date><risdate>1981</risdate><volume>11</volume><issue>6</issue><spage>419</spage><epage>433</epage><pages>419-433</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><abstract>The preejection period (PEP) of the fetal cardiac cycle was studied in the chronically instrumented fetal lamb. An inflatable cuff occluder was positioned around the maternal common internal iliac artery, the pregnant ewe's main uterine blood-supplying vessel. Occlusion of the maternal common internal iliac artery produced a fall in p O 2 and pH and a rise in p CO 2. Fetal arterial blood pressure increased and PEP shortened, especially in the longer lasting occlusions. Fetal heart rate exhibited a bradycardia also during this type of occlusion. The fetal lamb's cardiovascular adjustments to biochemical changes caused by occlusion of the maternal uterine blood supply appear to be determined during the initial phase of occlusion by a chemoreceptor reflex-induced peripheral vasoconstriction mediated by the adrenergic nervous system. This condition is comparable to the one observed during the second part of the umbilical cord occlusions. The interaction between a supersensitive fetal myocardium and the adrenal release of catecholamines may play a dominant role during the second part of occlusion in the longer lasting experiments. Increase in peripheral resistance in the course of redistribution of blood flow during hypoxemia induces a prolongation of the PEP in the early phase of occlusion; overriding of this effect by an increase in myocardial contractility due to rising levels of adrenal catecholamines abbreviates the PEP in the later part of the longer lasting occlusions.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>6265300</pmid><doi>10.1016/0028-2243(81)90091-5</doi><tpages>15</tpages></addata></record>
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source MEDLINE; Elsevier ScienceDirect Journals Complete
subjects Animals
Arterial Occlusive Diseases - physiopathology
Blood Pressure
cardiac function
chronic sheep experiments
Female
fetal distress
Fetal Heart - physiopathology
fetal heart rate patterns
Heart Rate
Hypoxia - physiopathology
Iliac Artery
late decelerations
Pregnancy
Pregnancy Complications, Cardiovascular - physiopathology
Receptors, Adrenergic, alpha - physiology
Receptors, Adrenergic, beta - physiology
Sheep
systolic time intervals
Time Factors
Uterus - blood supply
title The preejection period of the fetal cardiac cycle. II. Maternal common internal iliac artery occlusions
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