H-Y antigen negative patients with testicular tissue and 46,XY karyotype
H-Y antigen could not be detected on lymphocytes from two male pseudohermaphrodites with 46,XY karyotypes and testicular tissue. One of the patients had additional assays performed on fibroblasts grown from the skin, and the gonadal ridge--these were also negative. The H-Y antiserum was raised in ra...
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| Veröffentlicht in: | Human genetics 1981-01, Vol.57 (3), p.265-268 |
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| container_title | Human genetics |
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| creator | Haseltine, F P Genel, M Crawford, J D Breg, W R |
| description | H-Y antigen could not be detected on lymphocytes from two male pseudohermaphrodites with 46,XY karyotypes and testicular tissue. One of the patients had additional assays performed on fibroblasts grown from the skin, and the gonadal ridge--these were also negative. The H-Y antiserum was raised in rats, with Raji cells the target of cytotoxicity tests. In these patients. the substance that promoted testicular differentiation does not have serologic H-Y antigen detectable by the assay used. It appears that H-Y antigen that is commonly measured in neutralization reactions may not be the only form of testicular organizing factor present. |
| doi_str_mv | 10.1007/BF00278941 |
| format | Article |
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One of the patients had additional assays performed on fibroblasts grown from the skin, and the gonadal ridge--these were also negative. The H-Y antiserum was raised in rats, with Raji cells the target of cytotoxicity tests. In these patients. the substance that promoted testicular differentiation does not have serologic H-Y antigen detectable by the assay used. It appears that H-Y antigen that is commonly measured in neutralization reactions may not be the only form of testicular organizing factor present.</description><identifier>ISSN: 0340-6717</identifier><identifier>EISSN: 1432-1203</identifier><identifier>DOI: 10.1007/BF00278941</identifier><identifier>PMID: 7250968</identifier><language>eng</language><publisher>Germany</publisher><subject>Adolescent ; Adult ; Disorders of Sex Development - immunology ; Fibroblasts - analysis ; Gonadal Dysgenesis, Mixed - immunology ; H-Y Antigen - analysis ; Humans ; Karyotyping ; Lymphocytes - analysis ; Male ; Sex Chromosomes</subject><ispartof>Human genetics, 1981-01, Vol.57 (3), p.265-268</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-10ab9711325506184bc61717df3be0aaaddc3fb9e13af1e3dc92636cbe5caae33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7250968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haseltine, F P</creatorcontrib><creatorcontrib>Genel, M</creatorcontrib><creatorcontrib>Crawford, J D</creatorcontrib><creatorcontrib>Breg, W R</creatorcontrib><title>H-Y antigen negative patients with testicular tissue and 46,XY karyotype</title><title>Human genetics</title><addtitle>Hum Genet</addtitle><description>H-Y antigen could not be detected on lymphocytes from two male pseudohermaphrodites with 46,XY karyotypes and testicular tissue. One of the patients had additional assays performed on fibroblasts grown from the skin, and the gonadal ridge--these were also negative. The H-Y antiserum was raised in rats, with Raji cells the target of cytotoxicity tests. In these patients. the substance that promoted testicular differentiation does not have serologic H-Y antigen detectable by the assay used. It appears that H-Y antigen that is commonly measured in neutralization reactions may not be the only form of testicular organizing factor present.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Disorders of Sex Development - immunology</subject><subject>Fibroblasts - analysis</subject><subject>Gonadal Dysgenesis, Mixed - immunology</subject><subject>H-Y Antigen - analysis</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Lymphocytes - analysis</subject><subject>Male</subject><subject>Sex Chromosomes</subject><issn>0340-6717</issn><issn>1432-1203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL9PwzAQhS0EKqWwsCN5YkAE7nz5UY9QUYpUiQUkOkWOcymBNCmxA-p_T1ArGJne8t3Tu0-IU4QrBEiub6cAKhnrEPfEEENSASqgfTEECiGIE0wOxZFzbwAYaRUNxCBREeh4PBSzWbCQpvblkmtZ89L48pPlug-uvZNfpX-Vnp0vbVeZVvrSuY77g1yG8eXLQr6bdtP4zZqPxUFhKscnuxyJ5-nd02QWzB_vHyY388ASkg8QTKYTRFJRBDGOw8zG2A_MC8oYjDF5bqnINCOZAplyq1VMsc04ssYw0Uicb3vXbfPR9cvSVeksV5WpuelcmlAUggL9L4gRhRq06sGLLWjbxrmWi3Tdlqv-rxQh_fGb_vnt4bNda5etOP9Fd0LpG2PldHQ</recordid><startdate>19810101</startdate><enddate>19810101</enddate><creator>Haseltine, F P</creator><creator>Genel, M</creator><creator>Crawford, J D</creator><creator>Breg, W R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19810101</creationdate><title>H-Y antigen negative patients with testicular tissue and 46,XY karyotype</title><author>Haseltine, F P ; Genel, M ; Crawford, J D ; Breg, W R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-10ab9711325506184bc61717df3be0aaaddc3fb9e13af1e3dc92636cbe5caae33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Disorders of Sex Development - immunology</topic><topic>Fibroblasts - analysis</topic><topic>Gonadal Dysgenesis, Mixed - immunology</topic><topic>H-Y Antigen - analysis</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Lymphocytes - analysis</topic><topic>Male</topic><topic>Sex Chromosomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haseltine, F P</creatorcontrib><creatorcontrib>Genel, M</creatorcontrib><creatorcontrib>Crawford, J D</creatorcontrib><creatorcontrib>Breg, W R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haseltine, F P</au><au>Genel, M</au><au>Crawford, J D</au><au>Breg, W R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>H-Y antigen negative patients with testicular tissue and 46,XY karyotype</atitle><jtitle>Human genetics</jtitle><addtitle>Hum Genet</addtitle><date>1981-01-01</date><risdate>1981</risdate><volume>57</volume><issue>3</issue><spage>265</spage><epage>268</epage><pages>265-268</pages><issn>0340-6717</issn><eissn>1432-1203</eissn><abstract>H-Y antigen could not be detected on lymphocytes from two male pseudohermaphrodites with 46,XY karyotypes and testicular tissue. One of the patients had additional assays performed on fibroblasts grown from the skin, and the gonadal ridge--these were also negative. The H-Y antiserum was raised in rats, with Raji cells the target of cytotoxicity tests. In these patients. the substance that promoted testicular differentiation does not have serologic H-Y antigen detectable by the assay used. It appears that H-Y antigen that is commonly measured in neutralization reactions may not be the only form of testicular organizing factor present.</abstract><cop>Germany</cop><pmid>7250968</pmid><doi>10.1007/BF00278941</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-6717 |
| ispartof | Human genetics, 1981-01, Vol.57 (3), p.265-268 |
| issn | 0340-6717 1432-1203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73540209 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Adult Disorders of Sex Development - immunology Fibroblasts - analysis Gonadal Dysgenesis, Mixed - immunology H-Y Antigen - analysis Humans Karyotyping Lymphocytes - analysis Male Sex Chromosomes |
| title | H-Y antigen negative patients with testicular tissue and 46,XY karyotype |
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