Metabolism of PGP peptide after administration via different routes
Main pathways of degradation of PGP peptide possessing antiulcer and antithrombotic activities were studied after its intraperitoneal, intragastric, and intraintestinal administration. In experiments on rabbits we showed by HPLC that unmodified PGP is released into the blood after administration by...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2003-04, Vol.135 (4), p.361-364 |
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| container_end_page | 364 |
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| container_issue | 4 |
| container_start_page | 361 |
| container_title | Bulletin of experimental biology and medicine |
| container_volume | 135 |
| creator | Zolotarev, Yu A Zhuikova, S E Ashmarin, I P Myasoedov, N F Vas'kovskii, B V Samonina, G E |
| description | Main pathways of degradation of PGP peptide possessing antiulcer and antithrombotic activities were studied after its intraperitoneal, intragastric, and intraintestinal administration. In experiments on rabbits we showed by HPLC that unmodified PGP is released into the blood after administration by all three routes and is detected in the plasma over 3-5 h. PG dipeptide is a more stable PGP metabolite presumably determining (together with tripeptide) its pharmacological properties. |
| doi_str_mv | 10.1023/A:1024612831380 |
| format | Article |
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PG dipeptide is a more stable PGP metabolite presumably determining (together with tripeptide) its pharmacological properties.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1023/A:1024612831380</identifier><identifier>PMID: 12910309</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Drug Administration Routes ; Female ; Peptides - administration & dosage ; Peptides - chemistry ; Peptides - metabolism ; Rabbits ; Tritium - metabolism</subject><ispartof>Bulletin of experimental biology and medicine, 2003-04, Vol.135 (4), p.361-364</ispartof><rights>Copyright (c) 2003 Plenum Publishing Corporation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c280t-84aa331af3020bdd69a44a399b466d9c7930fe6a0ceed0d79b01bb921ac9266f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12910309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zolotarev, Yu A</creatorcontrib><creatorcontrib>Zhuikova, S E</creatorcontrib><creatorcontrib>Ashmarin, I P</creatorcontrib><creatorcontrib>Myasoedov, N F</creatorcontrib><creatorcontrib>Vas'kovskii, B V</creatorcontrib><creatorcontrib>Samonina, G E</creatorcontrib><title>Metabolism of PGP peptide after administration via different routes</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><description>Main pathways of degradation of PGP peptide possessing antiulcer and antithrombotic activities were studied after its intraperitoneal, intragastric, and intraintestinal administration. 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| identifier | ISSN: 0007-4888 |
| ispartof | Bulletin of experimental biology and medicine, 2003-04, Vol.135 (4), p.361-364 |
| issn | 0007-4888 1573-8221 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73539836 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Drug Administration Routes Female Peptides - administration & dosage Peptides - chemistry Peptides - metabolism Rabbits Tritium - metabolism |
| title | Metabolism of PGP peptide after administration via different routes |
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