Oval corneal opacities in beagles. III. Histochemical demonstration of stromal lipids without hyperlipidemia
We found oral stromal avascular corneal opacities in 128 eyes of 75 beagles from 497 studied. There were three morphologic types that progressed in severity with time; nebular, racetrack, and white arc. Histochemical study of the earliest morphologic type (nebular) revealed neutral fats, cholesterol...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 1981-07, Vol.21 (1), p.95-106 |
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| creator | Roth, AM Ekins, MB Waring, GO, 3d Gupta, LM Rosenblatt, LS |
| description | We found oral stromal avascular corneal opacities in 128 eyes of 75 beagles from 497 studied. There were three morphologic types that progressed in severity with time; nebular, racetrack, and white arc. Histochemical study of the earliest morphologic type (nebular) revealed neutral fats, cholesterol, phospholipids, and sometimes fatty acids both intracellularly and extracellularly. We found no elevation of serum cholesterol or triglycerides except in dogs with the most advanced morphologic type (white arc) and no alteration in thyrometabolic function. We think that oval stromal opacities in beagle corneas are a primary disorder of corneal lipid metabolism closely resembling the central crystalline dystrophy of Schnyder and may be an animal model for this human disease. |
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Histochemical demonstration of stromal lipids without hyperlipidemia</title><source>MEDLINE</source><source>EZB Electronic Journals Library</source><creator>Roth, AM ; Ekins, MB ; Waring, GO, 3d ; Gupta, LM ; Rosenblatt, LS</creator><creatorcontrib>Roth, AM ; Ekins, MB ; Waring, GO, 3d ; Gupta, LM ; Rosenblatt, LS</creatorcontrib><description>We found oral stromal avascular corneal opacities in 128 eyes of 75 beagles from 497 studied. There were three morphologic types that progressed in severity with time; nebular, racetrack, and white arc. Histochemical study of the earliest morphologic type (nebular) revealed neutral fats, cholesterol, phospholipids, and sometimes fatty acids both intracellularly and extracellularly. We found no elevation of serum cholesterol or triglycerides except in dogs with the most advanced morphologic type (white arc) and no alteration in thyrometabolic function. We think that oval stromal opacities in beagle corneas are a primary disorder of corneal lipid metabolism closely resembling the central crystalline dystrophy of Schnyder and may be an animal model for this human disease.</description><identifier>ISSN: 0146-0404</identifier><identifier>EISSN: 1552-5783</identifier><identifier>PMID: 7251305</identifier><language>eng</language><publisher>United States: ARVO</publisher><subject>Animals ; Cholesterol - analysis ; Cornea - analysis ; Corneal Opacity - pathology ; Corneal Opacity - physiopathology ; Disease Models, Animal ; Dogs ; Fatty Acids - analysis ; Histocytochemistry ; Lipids - analysis ; Phospholipids - analysis</subject><ispartof>Investigative ophthalmology & visual science, 1981-07, Vol.21 (1), p.95-106</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7251305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roth, AM</creatorcontrib><creatorcontrib>Ekins, MB</creatorcontrib><creatorcontrib>Waring, GO, 3d</creatorcontrib><creatorcontrib>Gupta, LM</creatorcontrib><creatorcontrib>Rosenblatt, LS</creatorcontrib><title>Oval corneal opacities in beagles. III. Histochemical demonstration of stromal lipids without hyperlipidemia</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>We found oral stromal avascular corneal opacities in 128 eyes of 75 beagles from 497 studied. There were three morphologic types that progressed in severity with time; nebular, racetrack, and white arc. Histochemical study of the earliest morphologic type (nebular) revealed neutral fats, cholesterol, phospholipids, and sometimes fatty acids both intracellularly and extracellularly. We found no elevation of serum cholesterol or triglycerides except in dogs with the most advanced morphologic type (white arc) and no alteration in thyrometabolic function. We think that oval stromal opacities in beagle corneas are a primary disorder of corneal lipid metabolism closely resembling the central crystalline dystrophy of Schnyder and may be an animal model for this human disease.</description><subject>Animals</subject><subject>Cholesterol - analysis</subject><subject>Cornea - analysis</subject><subject>Corneal Opacity - pathology</subject><subject>Corneal Opacity - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Fatty Acids - analysis</subject><subject>Histocytochemistry</subject><subject>Lipids - analysis</subject><subject>Phospholipids - analysis</subject><issn>0146-0404</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkMtOwzAQRS0EKqXwCUheIHap_IjzWKIKaKRK3cDaspNJY-TEIXaI-vdY0NUdzT3zvEJrKgRLRF7wa7QmNM0SkpL0Ft15_0UIo5SRFVrlTFBOxBrZ44-yuHbTAFHdqGoTDHhsBqxBnSz4La6qaov3xgdXd9CbOoIN9G7wYVLBuAG7FsfY9dGwZjSNx4sJnZsD7s4jTH-5WKju0U2rrIeHi27Q59vrx26fHI7v1e7lkHRUkJBAoVugqmatJkI3CkRcNmt42eZ5IUSaC66YUIXiZV4XZZaCVkAyJYpUM6YzvkHP_33HyX3P4IPsja_BWjWAm73MueBFHBXBxws46x4aOU6mV9NZXt4T_ad_vzOnbjETSB-PtJGmclkWRiWVpeC_un5wgQ</recordid><startdate>198107</startdate><enddate>198107</enddate><creator>Roth, AM</creator><creator>Ekins, MB</creator><creator>Waring, GO, 3d</creator><creator>Gupta, LM</creator><creator>Rosenblatt, LS</creator><general>ARVO</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198107</creationdate><title>Oval corneal opacities in beagles. 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Histochemical demonstration of stromal lipids without hyperlipidemia</title><author>Roth, AM ; Ekins, MB ; Waring, GO, 3d ; Gupta, LM ; Rosenblatt, LS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h150t-e8bfe1ac2fb05bdae55136d39f778554753a25a8a397c8964ebae06a584b22b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Cholesterol - analysis</topic><topic>Cornea - analysis</topic><topic>Corneal Opacity - pathology</topic><topic>Corneal Opacity - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Fatty Acids - analysis</topic><topic>Histocytochemistry</topic><topic>Lipids - analysis</topic><topic>Phospholipids - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roth, AM</creatorcontrib><creatorcontrib>Ekins, MB</creatorcontrib><creatorcontrib>Waring, GO, 3d</creatorcontrib><creatorcontrib>Gupta, LM</creatorcontrib><creatorcontrib>Rosenblatt, LS</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roth, AM</au><au>Ekins, MB</au><au>Waring, GO, 3d</au><au>Gupta, LM</au><au>Rosenblatt, LS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oval corneal opacities in beagles. III. Histochemical demonstration of stromal lipids without hyperlipidemia</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>1981-07</date><risdate>1981</risdate><volume>21</volume><issue>1</issue><spage>95</spage><epage>106</epage><pages>95-106</pages><issn>0146-0404</issn><eissn>1552-5783</eissn><abstract>We found oral stromal avascular corneal opacities in 128 eyes of 75 beagles from 497 studied. There were three morphologic types that progressed in severity with time; nebular, racetrack, and white arc. Histochemical study of the earliest morphologic type (nebular) revealed neutral fats, cholesterol, phospholipids, and sometimes fatty acids both intracellularly and extracellularly. We found no elevation of serum cholesterol or triglycerides except in dogs with the most advanced morphologic type (white arc) and no alteration in thyrometabolic function. We think that oval stromal opacities in beagle corneas are a primary disorder of corneal lipid metabolism closely resembling the central crystalline dystrophy of Schnyder and may be an animal model for this human disease.</abstract><cop>United States</cop><pub>ARVO</pub><pmid>7251305</pmid><tpages>12</tpages></addata></record> |
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| ispartof | Investigative ophthalmology & visual science, 1981-07, Vol.21 (1), p.95-106 |
| issn | 0146-0404 1552-5783 |
| language | eng |
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| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Animals Cholesterol - analysis Cornea - analysis Corneal Opacity - pathology Corneal Opacity - physiopathology Disease Models, Animal Dogs Fatty Acids - analysis Histocytochemistry Lipids - analysis Phospholipids - analysis |
| title | Oval corneal opacities in beagles. III. Histochemical demonstration of stromal lipids without hyperlipidemia |
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