Membrane-bound complement regulatory proteins inhibit complement activation by an immunotherapeutic mAb in a syngeneic rat colorectal cancer model

MAb-mediated immunotherapy offers a potential tool for destroying metastasizing colorectal tumor cells. Promising results have been obtained by using xenograft models. However, overexpression of membrane-bound complement regulatory proteins (mCRP) impedes complement-mediated destruction of tumor cel...

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Veröffentlicht in:	Molecular immunology 2003-09, Vol.40 (1), p.13-23
Hauptverfasser:	Gelderman, K.A., Hakulinen, J., Hagenaars, M., Kuppen, P.J.K., Meri, S., Gorter, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Antigens, Surface CC531 CD55 CD55 Antigens - analysis CD55 Antigens - physiology CD59 CD59 Antigens - analysis CD59 Antigens - physiology Colon carcinoma Colorectal Neoplasms - immunology Colorectal Neoplasms - therapy Complement Complement Activation Complement System Proteins - immunology Crry/p65 Immunotherapy Rat Rats Receptors, Cell Surface Receptors, Complement - analysis Receptors, Complement - physiology Tumor Cells, Cultured
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