BldD from Streptomyces coelicolor is a non-essential global regulator that binds its own promoter as a dimer
We have shown that the bldD gene of Streptomyces coelicolor, while required for antibiotic production and morphological differentiation, is not essential for viability. We have also demonstrated that BldD forms a higher order complex both in solution and when bound to target DNA. Purified BldD exist...
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| Veröffentlicht in: | FEMS microbiology letters 2003-08, Vol.225 (1), p.35-40 |
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| container_title | FEMS microbiology letters |
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| creator | Elliot, Marie A Locke, Troy R Galibois, Claire M Leskiw, Brenda K |
| description | We have shown that the
bldD gene of
Streptomyces coelicolor, while required for antibiotic production and morphological differentiation, is not essential for viability. We have also demonstrated that BldD forms a higher order complex both in solution and when bound to target DNA. Purified BldD exists in three forms in solution, as a tetramer, dimer and monomer, but only in the dimeric form when bound to its own promoter/operator. |
| doi_str_mv | 10.1016/S0378-1097(03)00474-9 |
| format | Article |
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bldD gene of
Streptomyces coelicolor, while required for antibiotic production and morphological differentiation, is not essential for viability. We have also demonstrated that BldD forms a higher order complex both in solution and when bound to target DNA. Purified BldD exists in three forms in solution, as a tetramer, dimer and monomer, but only in the dimeric form when bound to its own promoter/operator.</description><identifier>ISSN: 0378-1097</identifier><identifier>EISSN: 1574-6968</identifier><identifier>DOI: 10.1016/S0378-1097(03)00474-9</identifier><identifier>PMID: 12900018</identifier><identifier>CODEN: FMLED7</identifier><language>eng</language><publisher>Oxford, UK: Elsevier B.V</publisher><subject>Antibiotic production ; Bacterial Proteins - chemistry ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Bacteriology ; Base Sequence ; Biological and medical sciences ; Dimerization ; DNA binding ; DNA, Bacterial - genetics ; DNA, Bacterial - metabolism ; DNA-Binding Proteins - chemistry ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Fundamental and applied biological sciences. Psychology ; Gene Deletion ; Genes, Bacterial ; Genetics ; Global regulator ; Growth, nutrition, cell differenciation ; Microbiology ; Morphological differentiation ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; Phenotype ; Point Mutation ; Promoter Regions, Genetic ; Protein Structure, Quaternary ; Solutions ; Streptomyces - genetics ; Streptomyces - metabolism ; Transcription Factors - chemistry ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>FEMS microbiology letters, 2003-08, Vol.225 (1), p.35-40</ispartof><rights>2003 Federation of European Microbiological Societies</rights><rights>2003 Federation of European Microbiological Societies 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5125-1dd31384a4cf63ca865995390127ed0fb47123cae7256bfa374a8942a69b6fdd3</citedby><cites>FETCH-LOGICAL-c5125-1dd31384a4cf63ca865995390127ed0fb47123cae7256bfa374a8942a69b6fdd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2FS0378-1097%2803%2900474-9$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2FS0378-1097%2803%2900474-9$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27926,27927,45576,45577</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15204016$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12900018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elliot, Marie A</creatorcontrib><creatorcontrib>Locke, Troy R</creatorcontrib><creatorcontrib>Galibois, Claire M</creatorcontrib><creatorcontrib>Leskiw, Brenda K</creatorcontrib><title>BldD from Streptomyces coelicolor is a non-essential global regulator that binds its own promoter as a dimer</title><title>FEMS microbiology letters</title><addtitle>FEMS Microbiol Lett</addtitle><description>We have shown that the
bldD gene of
Streptomyces coelicolor, while required for antibiotic production and morphological differentiation, is not essential for viability. We have also demonstrated that BldD forms a higher order complex both in solution and when bound to target DNA. Purified BldD exists in three forms in solution, as a tetramer, dimer and monomer, but only in the dimeric form when bound to its own promoter/operator.</description><subject>Antibiotic production</subject><subject>Bacterial Proteins - chemistry</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>Bacteriology</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Dimerization</subject><subject>DNA binding</subject><subject>DNA, Bacterial - genetics</subject><subject>DNA, Bacterial - metabolism</subject><subject>DNA-Binding Proteins - chemistry</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Deletion</subject><subject>Genes, Bacterial</subject><subject>Genetics</subject><subject>Global regulator</subject><subject>Growth, nutrition, cell differenciation</subject><subject>Microbiology</subject><subject>Morphological differentiation</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Phenotype</subject><subject>Point Mutation</subject><subject>Promoter Regions, Genetic</subject><subject>Protein Structure, Quaternary</subject><subject>Solutions</subject><subject>Streptomyces - genetics</subject><subject>Streptomyces - metabolism</subject><subject>Transcription Factors - chemistry</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>0378-1097</issn><issn>1574-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV1vFCEUhonR2O3qT9Bwo6kXU_mYYeDKaLW1yRovqteEYc5UDDOswNjsv5ftbNqYmNSrA-R5DhxehF5QckoJFW-vCG9lRYlqTwh_Q0jd1pV6hFa0KQuhhHyMVnfIETpO6ScpFCPiKTqiTJUNlSvkP_j-Ix5iGPFVjrDNYdxZSNgG8M4GHyJ2CRs8hamClGDKznh87UNXSoTr2ZtcmPzDZNy5qU_Y5YTDzYS3pWfIELHZ-70bIT5DTwbjEzw_1DX6fv7p29nnavP14vLs_aayDWVNRfueUy5rU9tBcGukaJRquCKUtdCToatbyso5tKwR3WB4WxupamaE6sRQ5DV6vfQtb_g1Q8p6dMmC92aCMCfd8oYLQtiDIJVSMMlFAZsFtDGkFGHQ2-hGE3eaEr3PQ9_mofefrQnXt3loVbyXhwvmboT-3joEUIBXB8Aka_wQzWRduucaRurSvnBy4W6ch93_3a7Pv2zKpGtEFjXM23-L1V9itX_2u0WBktJvB1En62Cy0LsINus-uAcG_wMu78V4</recordid><startdate>20030808</startdate><enddate>20030808</enddate><creator>Elliot, Marie A</creator><creator>Locke, Troy R</creator><creator>Galibois, Claire M</creator><creator>Leskiw, Brenda K</creator><general>Elsevier B.V</general><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030808</creationdate><title>BldD from Streptomyces coelicolor is a non-essential global regulator that binds its own promoter as a dimer</title><author>Elliot, Marie A ; Locke, Troy R ; Galibois, Claire M ; Leskiw, Brenda K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5125-1dd31384a4cf63ca865995390127ed0fb47123cae7256bfa374a8942a69b6fdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Antibiotic production</topic><topic>Bacterial Proteins - chemistry</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>Bacteriology</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Dimerization</topic><topic>DNA binding</topic><topic>DNA, Bacterial - genetics</topic><topic>DNA, Bacterial - metabolism</topic><topic>DNA-Binding Proteins - chemistry</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Deletion</topic><topic>Genes, Bacterial</topic><topic>Genetics</topic><topic>Global regulator</topic><topic>Growth, nutrition, cell differenciation</topic><topic>Microbiology</topic><topic>Morphological differentiation</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>Phenotype</topic><topic>Point Mutation</topic><topic>Promoter Regions, Genetic</topic><topic>Protein Structure, Quaternary</topic><topic>Solutions</topic><topic>Streptomyces - genetics</topic><topic>Streptomyces - metabolism</topic><topic>Transcription Factors - chemistry</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elliot, Marie A</creatorcontrib><creatorcontrib>Locke, Troy R</creatorcontrib><creatorcontrib>Galibois, Claire M</creatorcontrib><creatorcontrib>Leskiw, Brenda K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEMS microbiology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elliot, Marie A</au><au>Locke, Troy R</au><au>Galibois, Claire M</au><au>Leskiw, Brenda K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BldD from Streptomyces coelicolor is a non-essential global regulator that binds its own promoter as a dimer</atitle><jtitle>FEMS microbiology letters</jtitle><addtitle>FEMS Microbiol Lett</addtitle><date>2003-08-08</date><risdate>2003</risdate><volume>225</volume><issue>1</issue><spage>35</spage><epage>40</epage><pages>35-40</pages><issn>0378-1097</issn><eissn>1574-6968</eissn><coden>FMLED7</coden><abstract>We have shown that the
bldD gene of
Streptomyces coelicolor, while required for antibiotic production and morphological differentiation, is not essential for viability. We have also demonstrated that BldD forms a higher order complex both in solution and when bound to target DNA. Purified BldD exists in three forms in solution, as a tetramer, dimer and monomer, but only in the dimeric form when bound to its own promoter/operator.</abstract><cop>Oxford, UK</cop><pub>Elsevier B.V</pub><pmid>12900018</pmid><doi>10.1016/S0378-1097(03)00474-9</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | FEMS microbiology letters, 2003-08, Vol.225 (1), p.35-40 |
| issn | 0378-1097 1574-6968 |
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| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Antibiotic production Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Base Sequence Biological and medical sciences Dimerization DNA binding DNA, Bacterial - genetics DNA, Bacterial - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Gene Deletion Genes, Bacterial Genetics Global regulator Growth, nutrition, cell differenciation Microbiology Morphological differentiation Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Phenotype Point Mutation Promoter Regions, Genetic Protein Structure, Quaternary Solutions Streptomyces - genetics Streptomyces - metabolism Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism |
| title | BldD from Streptomyces coelicolor is a non-essential global regulator that binds its own promoter as a dimer |
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