Relationship between airway hyperresponsiveness to mannitol and adenosine monophosphate

Background: Assessment of airway hyperresponsiveness (AHR) to indirect bronchoconstrictor stimuli is a useful noninvasive tool in the evaluation of asthma and its treatment. We investigated the putative relationship in AHR between inhaled adenosine monophosphate and mannitol. Methods: Fifteen mild‐t...

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Veröffentlicht in:	Allergy (Copenhagen) 2003-08, Vol.58 (8), p.762-766
Hauptverfasser:	Currie, G. P., Haggart, K., Brannan, J. D., Lee, D. K. C., Anderson, S. D., Lipworth, B. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Monophosphate Adult Aerosols airway hyperresponsiveness Allergic diseases AMP Asthma - diagnosis Asthma - physiopathology Biological and medical sciences Bronchial Hyperreactivity - diagnosis Bronchial Provocation Tests Chronic obstructive pulmonary disease, asthma Cross-Over Studies Double-Blind Method Female Forced Expiratory Volume Humans Immunopathology Male Mannitol Medical sciences Middle Aged Pneumology Powders Respiratory and ent allergic diseases Spirometry
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Zusammenfassung:	Background: Assessment of airway hyperresponsiveness (AHR) to indirect bronchoconstrictor stimuli is a useful noninvasive tool in the evaluation of asthma and its treatment. We investigated the putative relationship in AHR between inhaled adenosine monophosphate and mannitol. Methods: Fifteen mild‐to‐moderate atopic asthmatics were evaluated. On two separate screening days, the threshold AMP concentration and threshold mannitol dose to provoke a given fall in FEV1 were measured. Results: For AMP PC20vs. mannitol PD15, the Pearsons correlation coefficient was 0.80, P
ISSN:	0105-4538 1398-9995
DOI:	10.1034/j.1398-9995.2003.00226.x