Caspase activity is essential for long-term potentiation

Slices from rat hippocampus were incubated with the caspase‐3 inhibitor N‐benzyloxycarbonyl‐Asp‐Glu‐Val‐Asp fluoromethylketone (Z‐DEVD‐FMK) or with the inactive peptide N‐benzyloxycarbonyl‐Phe‐Ala fluoromethylketone (Z‐Phe‐Ala‐FMK) for 30 min. The peptides changed neither input–output curves nor pai...

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Veröffentlicht in:	Journal of neuroscience research 2003-09, Vol.73 (6), p.853-864
Hauptverfasser:	Gulyaeva, Natalia V., Kudryashov, Igor E., Kudryashova, Irina V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Animals CA1 Calpain - pharmacology Caspase 3 Caspase Inhibitors Caspases - physiology Cysteine Proteinase Inhibitors - pharmacology Dipeptides - pharmacology Electric Stimulation Enzyme Precursors - metabolism Enzyme Precursors - physiology hippocampal slices Hippocampus - anatomy & histology Hippocampus - drug effects Hippocampus - physiology In Vitro Techniques Ketones - pharmacology long-term potentiation (LTP) Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Oligopeptides - pharmacology Rats Time Factors Z-DEVD-FMK
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